Showing Protein Homeodomain-interacting protein kinase 3 (CDBP01182)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 2 compounds
Identification
HMDB Protein ID CDBP01182
Secondary Accession Numbers Not Available
Name Homeodomain-interacting protein kinase 3
Description Not Available
Synonyms
  1. ANPK
  2. Androgen receptor-interacting nuclear protein kinase
  3. FIST
  4. Fas-interacting serine/threonine-protein kinase
  5. Homolog of protein kinase YAK1
Gene Name HIPK3
Protein Type Enzyme
Biological Properties
General Function Involved in protein kinase activity
Specific Function Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors
GO Classification
Function
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
protein kinase activity
protein serine/threonine kinase activity
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
Process
phosphorus metabolic process
phosphate metabolic process
metabolic process
cellular metabolic process
protein amino acid phosphorylation
phosphorylation
Cellular Location
  1. Nucleus
  2. Cytoplasm
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 11p13
SNPs HIPK3
Gene Sequence 
>3648 bp
ATGGCCTCACAAGTCTTGGTCTACCCACCATATGTTTATCAAACTCAGTCAAGTGCCTTT
TGTAGTGTGAAGAAACTCAAAGTAGAGCCAAGCAGTTGTGTATTCCAGGAAAGAAACTAT
CCACGGACCTATGTGAATGGTAGAAACTTTGGAAATTCTCATCCTCCCACTAAGGGTAGT
GCTTTTCAGACAAAGATACCATTTAATAGACCTCGAGGACACAACTTTTCATTGCAGACA
AGTGCTGTTGTTTTGAAAAACACTGCAGGTGCTACAAAGGTCATAGCAGCTCAGGCACAG
CAAGCTCACGTGCAGGCACCTCAGATTGGGGTGTGGCGAAACAGATTGCATTTCCTAGAA
GGCCCCCAGCGATGTGGATTGAAGCGCAAGAGTGAGGAGTTGGATAATCATAGCAGCGCA
ATGCAGATTGTCGATGAATTGTCCATACTTCCTGCAATGTTGCAAACCAACATGGGAAAT
CCAGTGACAGTTGTGACAGCTACCACAGGATCAAAACAGAATTGTACCACTGGAGAAGGT
GACTATCAGTTAGTACAGCATGAAGTCTTATGCTCCATGAAAAATACTTACGAAGTCCTT
GATTTTCTTGGTCGAGGCACGTTTGGCCAGGTAGTTAAATGCTGGAAAAGAGGGACAAAT
GAAATTGTAGCAATCAAAATTTTGAAGAATCATCCTTCTTATGCCCGTCAAGGTCAAATA
GAAGTGAGCATATTAGCAAGGCTCAGTACTGAAAATGCTGATGAATATAACTTTGTACGA
GCTTATGAATGCTTTCAGCACCGTAACCATACTTGTTTAGTCTTTGAGATGCTGGAACAA
AACTTGTATGACTTTCTGAAACAAAATAAATTTAGTCCCCTGCCACTAAAAGTGATTCGG
CCCATTCTTCAACAAGTGGCCACTGCACTGAAAAAATTGAAAAGTCTTGGTTTAATTCAT
GCTGATCTCAAGCCAGAGAATATTATGTTGGTGGATCCTGTTCGGCAGCCTTACAGGGTT
AAAGTAATAGACTTTGGGTCGGCCAGTCATGTATCAAAGACTGTTTGTTCAACATATCTA
CAATCTCGGTACTACAGAGCTCCAGAGATTATATTGGGGTTGCCATTTTGTGAAGCCATA
GACATGTGGTCATTGGGATGTGTGATTGCAGAATTATTTCTTGGATGGCCGCTCTACCCA
GGAGCCTTGGAGTATGATCAGATTCGATACATTTCTCAGACTCAAGGTTTGCCAGGAGAA
CAGTTGTTAAATGTGGGTACTAAATCCACAAGATTTTTTTGCAAAGAAACAGATATGTCT
CATTCTGGTTGGAGATTAAAGACATTGGAAGAGCATGAGGCAGAGACAGGAATGAAGTCT
AAAGAAGCCAGAAAATACATTTTCAACAGTCTGGATGATGTAGCGCATGTGAACACAGTG
ATGGATTTGGAAGGAAGTGATCTTTTGGCTGAGAAAGCTGATAGAAGAGAATTTGTTAGT
CTGTTGAAGAAAATGTTGCTGATTGATGCAGATTTAAGAATTACTCCAGCTGAGACCCTG
AACCATCCTTTTGTTAATATGAAACATCTTCTAGATTTCCCTCATAGCAACCATGTAAAG
TCCTGTTTTCATATTATGGATATTTGTAAGTCCCACCTAAATTCATGTGACACAAATAAT
CACAACAAAACTTCACTTTTAAGACCAGTTGCTTCAAGCAGTACTGCTACACTGACTGCA
AATTTTACTAAAATCGGAACATTAAGAAGTCAGGCATTGACCACATCTGCTCATTCAGTT
GTGCACCATGGAATACCTCTGCAGGCAGGAACTGCTCAGTTTGGTTGTGGTGATGCTTTT
CAGCAGACATTGATTATCTGTCCCCCAGCTATTCAAGGTATTCCTGCAACACATGGTAAA
CCCACCAGTTATTCAATAAGGGTAGATAATACAGTTCCACTTGTAACTCAGGCCCCAGCT
GTGCAGCCACTACAGATCCGACCAGGAGTTCTTTCTCAGACGTGGTCTGGTAGAACACAG
CAGATGCTGGTGCCTGCCTGGCAACAGGTGACACCCCTGGCTCCTGCTACTACTACACTA
ACTTCTGAGAGTGTGGCTGGTTCACACAGGCTTGGAGACTGGGGGAAGATGATTTCATGC
AGCAATCATTATAACTCAGTGATGCCGCAGCCTCTTCTGACCAATCAGATAACTTTATCT
GCCCCTCAGCCAGTTAGTGTGGGGATTGCACATGTTGTCTGGCCTCAGCCTGCCACTACC
AAGAAAAATAAACAGTGCCAGAACAGAGGTATTTTGGTAAAACTAATGGAATGGGAGCCA
GGAAGAGAGGAAATAAATGCTTTCAGTTGGAGTAATTCATTACAGAATACCAATATCCCA
CATTCAGCATTTATTTCTCCAAAGATAATTAATGGGAAAGATGTCGAGGAAGTAAGTTGT
ATAGAAACACAGGACAATCAGAACTCAGAAGGAGAGGCAAGAAATTGCTGTGAAACATCT
ATCAGACAGGACTCTGATTCATCAGTTTCAGACAAACAGCGGCAAACCATCATTATTGCC
GACTCCCCGAGTCCTGCAGTGAGTGTCATCACTATCAGCAGTGACACTGATGAGGAAGAG
ACTTCCCAGAGACATTCACTCAGAGAATGTAAAGGTAGTCTAGATTGTGAAGCTTGCCAG
AGCACTTTGAATATTGATCGGATGTGTTCATTAAGTAGTCCTGATAGTACTCTGAGTACC
AGCTCCTCAGGGCAGTCCAGCCCATCCCCCTGCAAGAGACCGAATAGTATGTCAGATGAA
GAGCAAGAAAGTAGTTGTGATACGGTGGATGGCTCTCCGACATCTGACTCTTCCGGGCAT
GACAGTCCATTTGCAGAGAGCACTTTTGTGGAGGACACTCATGAAAACACAGAATTGGTA
TCCTCTGCTGACACAGAAACCAAGCCAGCTGTCTGTTCTGTTGTGGTGCCACCAGTGGAA
CTAGAAAATGGCTTAAATGCCGATGAGCATATGGCAAACACAGATTCTATATGCCAGCCA
TTAATAAAAGGACGATCTGCCCCTGGAAGATTAAACCAGCCTTCTGCAGTGGGTACTCGT
CAGCAAAAATTGACATCAGCATTCCAGCAGCAGCATTTGAACTTCAGTCAGGTTCAGCAC
TTTGGATCTGGGCATCAAGAGTGGAATGGAAACTTTGGGCACAGAAGACAGCAAGCTTAT
ATTCCTACTAGTGTTACCAGTAATCCATTCACTCTTTCTCATGGAAGTCCCAATCACACA
GCAGTGCATGCCCACCTGGCTGGAAATACACACCTCGGAGGACAGCCTACTCTACTTCCA
TACCCATCATCAGCCACCCTCAGTAGTGCTGCACCAGTGGCCCACCTGTTAGCCTCTCCG
TGTACCTCAAGACCTATGTTACAGCATCCAACTTATAATATCTCCCATCCCAGTGGCATA
GTTCACCAAGTCCCAGTGGGCTTAAATCCCCGTCTGTTACCATCCCCAACCATTCATCAG
ACTCAGTACAAACCAATCTTCCCACCACATTCTTACATTGCAGCATCACCTGCATATACT
GGATTTCCACTGAGTCCAACAAAACTCAGCCAGTATCCATATATGTGA
Protein Properties
Number of Residues 1215
Molecular Weight 133742.1
Theoretical pI 7.46
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>Homeodomain-interacting protein kinase 3
MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSCVFQERNYPRTYVNGRNFGNSHPPTKGS
AFQTKIPFNRPRGHNFSLQTSAVVLKNTAGATKVIAAQAQQAHVQAPQIGAWRNRLHFLE
GPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTGSKQNCTTGEG
DYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQI
EVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIR
PILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYL
QSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGE
QLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTV
MDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSNHVK
SCFHIMDICKSHLNSCDTNNHNKTSLLRPVASSSTATLTANFTKIGTLRSQALTTSAHSV
VHHGIPLQAGTAQFGCGDAFQQTLIICPPAIQGIPATHGKPTSYSIRVDNTVPLVTQAPA
VQPLQIRPGVLSQTWSGRTQQMLVPAWQQVTPLAPATTTLTSESVAGSHRLGDWGKMISC
SNHYNSVMPQPLLTNQITLSAPQPVSVGIAHVVWPQPATTKKNKQCQNRGILVKLMEWEP
GREEINAFSWSNSLQNTNIPHSAFISPKIINGKDVEEVSCIETQDNQNSEGEARNCCETS
IRQDSDSSVSDKQRQTIIIADSPSPAVSVITISSDTDEEETSQRHSLRECKGSLDCEACQ
STLNIDRMCSLSSPDSTLSTSSSGQSSPSPCKRPNSMSDEEQESSCDTVDGSPTSDSSGH
DSPFAESTFVEDTHENTELVSSADTETKPAVCSVVVPPVELENGLNADEHMANTDSICQP
LIKGRSAPGRLNQPSAVGTRQQKLTSAFQQQHLNFSQVQHFGSGHQEWNGNFGHRRQQAY
IPTSVTSNPFTLSHGSPNHTAVHAHLAGNTHLGGQPTLLPYPSSATLSSAAPVAHLLASP
CTSRPMLQHPTYNISHPSGIVHQVPVGLNPRLLPSPTIHQTQYKPIFPPHSYIAASPAYT
GFPLSPTKLSQYPYM
GenBank ID Protein 2627331
UniProtKB/Swiss-Prot ID Q9H422
UniProtKB/Swiss-Prot Entry Name HIPK3_HUMAN
PDB IDs Not Available
GenBank Gene ID AF004849
GeneCard ID HIPK3
GenAtlas ID HIPK3
HGNC ID HGNC:4915
References
General References Not Available