Showing Protein Serine/threonine-protein kinase Nek4 (CDBP01085)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 3 compounds
Identification
HMDB Protein ID CDBP01085
Secondary Accession Numbers Not Available
Name Serine/threonine-protein kinase Nek4
Description Not Available
Synonyms
  1. Never in mitosis A-related kinase 4
  2. NimA-related protein kinase 4
  3. Serine/threonine-protein kinase 2
  4. Serine/threonine-protein kinase NRK2
Gene Name NEK4
Protein Type Enzyme
Biological Properties
General Function Involved in protein kinase activity
Specific Function Seems to act exclusively upon threonine residues
GO Classification
Function
protein serine/threonine kinase activity
purine nucleotide binding
binding
nucleotide binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
protein kinase activity
Process
phosphorus metabolic process
phosphate metabolic process
metabolic process
cellular metabolic process
biopolymer metabolism
biopolymer modification
protein modification
physiological process
metabolism
macromolecule metabolism
protein amino acid phosphorylation
phosphorylation
Cellular Location
  1. Nucleus (Probable)
Pathways
Gene Properties
Chromosome Location Chromosome:3
Locus 3p21.1
SNPs NEK4
Gene Sequence 
>2526 bp
ATGCCCCTGGCCGCCTACTGCTACCTGCGGGTCGTGGGCAAGGGGAGCTATGGAGAGGTG
ACGCTTGTGAAGCACCGGCGGGACGGCAAGCAGTATGTCATCAAAAAACTGAACCTCCGA
AATGCCTCTAGCCGAGAGCGGCGAGCTGCTGAACAGGAAGCCCAGCTCTTGTCTCAGTTG
AAGCATCCCAACATTGTCACCTACAAGGAGTCATGGGAAGGAGGAGATGGTCTGCTCTAC
ATTGTCATGGGCTTCTGTGAAGGAGGTGATTTGTACCGAAAGCTCAAGGAGCAGAAAGGG
CAGCTTCTGCCTGAGAATCAGGTGGTAGAGTGGTTTGTACAGATCGCCATGGCTTTGCAG
TATTTACATGAAAAACACATCCTTCATCGAGATCTGAAAACTCAAAATGTCTTCCTAACA
AGAACAAACATCATCAAAGTAGGGGACCTAGGAATTGCCCGAGTGTTAGAGAACCACTGT
GACATGGCTAGCACCCTCATTGGCACACCCTACTACATGAGCCCTGAATTGTTCTCAAAC
AAACCCTACAACTATAAGTCTGATGTTTGGGCTCTAGGATGCTGTGTCTATGAAATGGCC
ACCTTGAAGCATGCTTTCAATGCAAAAGATATGAATTCTTTAGTTTATCGGATTATTGAA
GGAAAGCTGCCACCAATGCCAAGAGATTACAGCCCAGAGCTGGCAGAACTGATAAGAACA
ATGCTGAGCAAAAGGCCTGAAGAAAGGCCGTCTGTGAGGAGCATCCTGAGGCAGCCTTAT
ATAAAGCGGCAAATCTCCTTCTTTTTGGAGGCCACAAAGATAAAAACCTCCAAAAATAAC
ATTAAAAATGGTGACTCTCAATCCAAGCCTTTTGCTACAGTGGTTTCTGGAGAGGCAGAA
TCAAATCATGAAGTAATCCACCCCCAACCACTCTCTTCTGAGGGCTCCCAGACATATATA
ATGGGTGAAGGCAAATGTTTGTCCCAGGAGAAACCCAGGGCCTCTGGTCTCTTGAAGTCA
CCTGCCAGTCTGAAAGCCCATACCTGCAAACAGGACTTGAGCAATACCACAGAACTAGCC
ACAATCAGTAGCGTAAATATTGACATCTTACCTGCAAAAGGGAGGGATTCAGTGAGTGAT
GGCTTTGTTCAGGAGAATCAGCCAAGATATTTGGATGCCTCTAATGAGTTAGGAGGTATA
TGCAGTATTTCTCAAGTGGAAGAGGAGATGCTGCAGGACAACACTAAATCCAGTGCCCAG
CCTGAAAACCTGATTCCCATGTGGTCCTCTGACATTGTCACTGGGGAAAAGAATGAACCA
GTGAAGCCTCTGCAGCCCCTAATCAAAGAACAAAAGCCAAAGGACCAGAGTCTTGCCCTG
TCGCCCAAGCTGGAGTGCAGTGGCACAATCTTGGCTCACAGCAACCTCCGCCTCCTGGGT
TCAAGTGATTCTCCAGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCGTGTGCCACCAC
GCCCAGGATCAAGTTGCTGGTGAATGTATTATAGAAAAACAGGGCAGAATCCACCCAGAT
TTACAGCCACACAACTCTGGGTCTGAACCTTCCCTGTCTCGACAGCGACGGCAAAAGAGG
AGAGAACAGACTGAGCACAGAGGGGAAAAGAGACAGGTCCGCAGAGATCTCTTTGCTTTC
CAAGAGTCGCCTCCTCGATTTTTGCCTTCTCATCCCATTGTTGGGAAAGTGGATGTCACA
TCAACACAAAAAGAGGCTGAAAACCAACGTAGAGTGGTCACTGGGTCTGTGAGCAGTTCA
AGGAGCAGTGAGATGTCATCATCAAAGGATCGACCATTATCAGCCAGAGAGAGGAGGCGA
CTAAAGCAGTCACAGGAAGAAATGTCCTCTTCAGGCCCTTCAGTGAGGAAAGCGTCTCTG
AGTGTAGCAGGGCCAGGAAAACCCCAGGAAGAAGACCAGCCCTTGCCTGCCCGACGGCTC
TCCTCTGACTGCAGCGTCACTCAGGAAAGGAAACAGATTCATTGTCTGTCTGAGGATGAG
TTAAGTTCTTCTACAAGTTCAACTGATAAGTCAGATGGGGATTACGGGGAAGGGAAAGGT
CAGACAAATGAAATTAATGCCTTGGTACAATTGATGACTCAGACCCTGAAACTGGATTCT
AAAGAGAGCTGTGAAGATGTCCCGGTAGCAAACCCAGTGTCAGAATTCAAACTTCATCGG
AAATATCGGGACACACTGATACTTCATGGGAAGGTTGCAGAAGAGGCAGAGGAAATCCAT
TTTAAAGAGCTACCTTCAGCTATTATGCCAGGTTCTGAAAAGATCAGGAGACTAGTTGAA
GTCTTGAGAACTGATGTAATTCGTGGCCTGGGAGTTCAGCTTTTAGAGCAGGTGTATGAT
CTTTTGGAGGAGGAGGATGAATTTGATAGAGAGGTACGTTTGCGGGAGCACATGGGTGAA
AAGTATACAACTTACAGTGTGAAAGCTCGCCAGTTGAAATTTTTTGAAGAAAACATGAAT
TTTTGA
Protein Properties
Number of Residues 841
Molecular Weight 94596.4
Theoretical pI 7.98
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>Serine/threonine-protein kinase Nek4
MPLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQL
KHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQ
YLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSN
KPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRT
MLSKRPEERPSVRSILRQPYIKRQISFFLEATKIKTSKNNIKNGDSQSKPFATVVSGEAE
SNHEVIHPQPLSSEGSQTYIMGEGKCLSQEKPRASGLLKSPASLKAHTCKQDLSNTTELA
TISSVNIDILPAKGRDSVSDGFVQENQPRYLDASNELGGICSISQVEEEMLQDNTKSSAQ
PENLIPMWSSDIVTGEKNEPVKPLQPLIKEQKPKDQSLALSPKLECSGTILAHSNLRLLG
SSDSPASASRVAGITGVCHHAQDQVAGECIIEKQGRIHPDLQPHNSGSEPSLSRQRRQKR
REQTEHRGEKRQVRRDLFAFQESPPRFLPSHPIVGKVDVTSTQKEAENQRRVVTGSVSSS
RSSEMSSSKDRPLSARERRRLKQSQEEMSSSGPSVRKASLSVAGPGKPQEEDQPLPARRL
SSDCSVTQERKQIHCLSEDELSSSTSSTDKSDGDYGEGKGQTNEINALVQLMTQTLKLDS
KESCEDVPVANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVE
VLRTDVIRGLGVQLLEQVYDLLEEEDEFDREVRLREHMGEKYTTYSVKARQLKFFEENMN
F
GenBank ID Protein 148839316
UniProtKB/Swiss-Prot ID P51957
UniProtKB/Swiss-Prot Entry Name NEK4_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_003157.4
GeneCard ID NEK4
GenAtlas ID NEK4
HGNC ID HGNC:11399
References
General References Not Available