| Identification |
|---|
| HMDB Protein ID
| CDBP01070 |
| Secondary Accession Numbers
| Not Available |
| Name
| Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma |
| Description
| Not Available |
| Synonyms
|
- PI3K-C2-gamma
- Phosphoinositide 3-kinase-C2-gamma
- PtdIns-3-kinase C2 subunit gamma
|
| Gene Name
| PIK3C2G |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| In vitro, phosphorylates PtdIns and PtdIns4P but not PtdIns(4,5)P2 |
| GO Classification
|
| Component |
| macromolecular complex |
| protein complex |
| phosphoinositide 3-kinase complex |
| Function |
| 1-phosphatidylinositol-3-kinase activity |
| binding |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| kinase activity |
| phosphotransferase activity, alcohol group as acceptor |
| protein binding |
| inositol or phosphatidylinositol kinase activity |
| lipid binding |
| phospholipid binding |
| phosphoinositide binding |
| lipid kinase activity |
| phosphoinositide 3-kinase activity |
| Process |
| metabolic process |
| cellular process |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| signal transduction |
| intracellular signal transduction |
| organophosphate metabolic process |
| phospholipid metabolic process |
| cell communication |
| second-messenger-mediated signaling |
| phosphoinositide-mediated signaling |
| glycerophospholipid metabolic process |
| phosphoinositide metabolic process |
| phosphoinositide phosphorylation |
|
| Cellular Location
|
- Peripheral membrane protein
- Membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 12p12 |
| SNPs
| PIK3C2G |
| Gene Sequence
|
>4335 bp
ATGGCATATTCTTGGCAAACGGATCCAAATCCTAATGAATCACACGAAAAGCAGTATGAA
CACCAAGAATTTCTCTTTGTAAATCAACCCCATTCTTCTAGCCAAGTCAGTCTGGGTTTT
GATCAGATAGTAGATGAGATCAGTGGCAAAATTCCACACTACGAGAGTGAAATTGATGAA
AACACCTTTTTTGTGCCCACTGCACCAAAATGGGACTCAACAGGGCATTCATTAAATGAA
GCACACCAAATATCCTTGAATGAATTCACTTCTAAAAGCCGTGAACTCTCCTGGCATCAA
GTTAGCAAAGCACCAGCAATTGGTTTTAGTCCTTCTGTGTTACCAAAACCTCAAAATACG
AATAAAGAATGCTCCTGGGGAAGCATAGGAAAACATCATGGTGCTGATGATTCCAGATTC
AGTATTTTAGCTCTATCATTCACAAGTTTGGATAAAATTAATCTAGAGAAAGAATTAGAA
AATGAAAATCATAACTACCATATAGGATTTGAAAGTAGCATTCCTCCAACAAATTCATCC
TTCTCAAGTGACTTCATGCCGAAAGAAGAGAATAAAAGGAGTGGACATGTGAACATTGTG
GAACCATCTTTGATGCTTTTGAAAGGCTCTCTTCAACCCGGAATGTGGGAAAGTACATGG
CAGAAGAATATAGAGTCAATAGGTTGTTCCATTCAGCTAGTGGAAGTACCTCAAAGCAGC
AATACGAGTCTGGCCTCTTTTTGCAACAAAGTAAAAAAAATCAGAGAAAGATATCATGCA
GCTGATGTTAATTTCAATTCTGGGAAGATCTGGAGCACTACTACAGCATTTCCGTATCAG
CTCTTTTCTAAGACCAAGTTTAATATACATATTTTTATTGATAACTCAACACAACCTCTT
CATTTTATGCCATGTGCTAATTATCTTGTCAAAGATCTAATTGCAGAAATTCTGCATTTT
TGCACAAATGACCAGCTACTCCCCAAAGATCATATTCTAAGTGTATGTGGCTCTGAAGAA
TTTTTACAAAACGACCACTGTTTGGGGAGCCACAAAATGTTTCAAAAAGATAAATCTGTT
ATTCAGCTCCACCTGCAGAAAAGTAGGGAAGCTCCAGGAAAGCTATCTCGAAAGCATGAA
GAGGACCACAGTCAGTTTTATCTGAATCAACTTCTAGAATTTATGCATATTTGGAAAGTA
TCCAGACAATGTCTCTTAACACTCATCAGAAAATATGACTTCCACCTGAAATACCTATTG
AAAACCCAGGAAAACGTGTATAATATTATTGAAGAAGTTAAAAAAATATGCAGTGTTCTA
GGGTGTGTGGAAACCAAACAAATTACAGATGCAGTAAATGAACTAAGTCTAATTCTTCAG
AGAAAAGGAGAGAATTTTTATCAAAGTTCAGAGACTTCAGCAAAAGGCTTGATAGAGAAG
GTAACAACTGAACTATCCACATCCATCTACCAGCTAATCAATGTCTACTGTAACAGCTTT
TATGCAGATTTTCAGCCTGTAAATGTACCTAGATGCACTTCCTATCTAAATCCCGGGCTT
CCTTCCCACCTCAGCTTCACAGTGTATGCAGCACACAACATTCCAGAAACCTGGGTGCAC
AGGATCAATTTTCCCCTTGAAATAAAGTCACTTCCAAGGGAATCCATGCTCACTGTAAAA
CTGTTTGGGATTGCCTGTGCAACCAACAATGCAAATTTACTGGCGTGGACTTGTCTTCCA
CTGTTTCCAAAAGAAAAATCCATTCTCGGGTCTATGCTGTTCAGCATGACATTACAGAGT
GAGCCTCCCGTAGAAATGATAACTCCAGGAGTGTGGGATGTAAGTCAGCCATCCCCGGTG
ACCCTGCAGATTGATTTTCCAGCTACTGGGTGGGAGTATATGAAACCTGATTCTGAAGAG
AATAGAAGTAATCTTGAAGAGCCACTAAAGGAGTGTATAAAACATATTGCCAGACTTTCA
CAGAAACAGACTCCCCTACTACTCTCTGAAGAAAAGAAAAGATATTTATGGTTTTATCGC
TTCTACTGCAATAATGAAAACTGCTCCCTTCCTTTAGTCCTGGGTAGTGCCCCTGGATGG
GATGAAAGGACTGTTTCAGAAATGCATACCATTTTGAGAAGATGGACATTTTCTCAACCT
TTAGAGGCTCTTGGGCTTTTGACTTCCAGTTTTCCAGATCAAGAAATTCGTAAAGTGGCA
GTTCAACAATTAGACAACCTCTTGAATGATGAACTACTGGAATATCTCCCACAGCTAGTT
CAGGCTGTCAAGTTTGAATGGAACCTTGAGAGTCCTTTAGTGCAACTTCTACTCCACCGC
TCCTTGCAGAGCATCCAGGTTGCCCATCGTCTTTACTGGCTGCTAAAAAATGCAGAAAAT
GAAGCTTATTTTAAAAGCTGGTATCAGAAGCTACTAGCTGCTCTCCAATTCTGTGCAGGT
AAAGCCTTGAATGATGAGTTTTCCAAGGAGCAGAAACTTATCAAAATTCTGGGAGATATT
GGGGAAAGAGTCAAGTCTGCCAGTGACCATCAAAGACAGGAGGTACTGAAGAAAGAAATT
GGCAGACTAGAAGAGTTCTTTCAAGATGTAAATACTTGTCATCTTCCTCTGAACCCTGCC
CTATGTATAAAAGGGATTGATCACGATGCATGTTCATATTTTACATCTAATGCTTTGCCA
TTGAAGATTACTTTCATCAATGCTAATCTGATGGGCAAAAACATCAGCATTATTTTTAAG
GCTGGAGATGATCTTCGTCAGGATATGCTTGTTCTGCAGCTTATTCAAGTGATGGACAAT
ATTTGGCTGCAGGAAGGCTTGGATATGCAAATGATCATTTATAGATGTCTATCCACAGGA
AAAGACCAAGGATTGGTGCAGATGGTACCTGATGCTGTGACCCTAGCAAAGATTCATCGC
CATTCTGGACTGATAGGACCATTGAAAGAAAATACAATTAAAAAGTGGTTCAGTCAGCAC
AACCACTTAAAGGCAGATTATGAAAAGGCCTTGAGGAACTTTTTCTACTCCTGTGCTGGC
TGGTGTGTGGTAACATTCATCCTGGGAGTATGTGACCGTCACAATGATAATATCATGCTG
ACAAAGTCGGGCCACATGTTTCATATTGACTTTGGAAAATTCTTAGGTCATGCACAAACA
TTTGGAGGGATAAAAAGGGACCGAGCTCCTTTCATTTTTACTTCAGAGATGGAATACTTT
ATTACAGAGGGTGGGAAAAACCCACAGCATTTTCAAGATTTTGTGGAACTTTGCTGTCGT
GCTTATAATATTATCAGAAAGCACAGCCAACTGCTCTTGAACCTGCTGGAAATGATGCTG
TATGCAGGACTGCCTGAGCTAAGTGGAATTCAAGACCTGAAATATGTGTATAATAATCTT
CGTCCACAAGACACAGACCTGGAAGCAACAAGTCATTTTACCAAGAAAATAAAGGAAAGT
CTGGAGTGTTTCCCTGTTAAATTGAATAACTTGATCCACACACTTGCACAAATGTCAGCC
ATAAGCCCTGCCAAATCTACTTCACAGACTTTTCCTCAGGAATCCTGTTTGCTGAGTACA
ACTAGGTCGATTGAAAGAGCAACAATTTTAGGGTTCAGCAAGAAATCCAGTAATCTGTAT
CTGATCCAGGTGACACACAGCAACAACGAAACAAGCCTGACAGAAAAATCATTTGAGCAG
TTTTCAAAACTTCACAGCCAACTTCAGAAGCAGTTTGCATCACTGACTCTCCCAGAGTTT
CCTCATTGGTGGCACCTACCTTTTACAAATTCAGATCACAGAAGATTCAGAGATCTAAAT
CATTACATGGAACAGATATTAAATGTATCACATGAAGTTACAAACAGTGATTGTGTACTT
AGCTTTTTCCTCTCTGAGGCTGTGCAACAAACAGTTGAAGAATCATCACCTGTGTACCTA
GGTGAGAAGTTTCCAGACAAGAAGCCTAAGGTGCAGTTAGTCATATCCTACGAGGATGTG
AAGCTGACCATACTAGTGAAACACATGAAAAACATTCATCTCCCAGATGGCTCTGCGCCC
AGTGCACATGTTGAATTTTATCTTTTACCATATCCCAGTGAAGTTCGTAGGAGGAAAACA
AAATCTGTTCCAAAATGTACGGACCCAACTTACAATGAAATTGTAGTATATGATGAAGTC
ACAGAGCTCCAAGGACATGTCTTAATGCTTATTGTGAAGAGTAAAACTGTATTTGTGGGA
GCAATTAACATCCGACTCTGTAGTGTCCCACTCGATAAAGAAAAATGGTATCCATTAGGA
AACAGTATAATTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1444 |
| Molecular Weight
| 165648.3 |
| Theoretical pI
| 6.92 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma
MAYSWQTDPNPNESHEKQYEHQEFLFVNQPHSSSQVSLGFDQIVDEISGKIPHYESEIDE
NTFFVPTAPKWDSTGHSLNEAHQISLNEFTSKSRELSWHQVSKAPAIGFSPSVLPKPQNT
NKECSWGSIGKHHGADDSRFSILALSFTSLDKINLEKELENENHNYHIGFESSIPPTNSS
FSSDFMPKEENKRSGHVNIVEPSLMLLKGSLQPGMWESTWQKNIESIGCSIQLVEVPQSS
NTSLASFCNKVKKIRERYHAADVNFNSGKIWSTTTAFPYQLFSKTKFNIHIFIDNSTQPL
HFMPCANYLVKDLIAEILHFCTNDQLLPKDHILSVCGSEEFLQNDHCLGSHKMFQKDKSV
IQLHLQKSREAPGKLSRKHEEDHSQFYLNQLLEFMHIWKVSRQCLLTLIRKYDFHLKYLL
KTQENVYNIIEEVKKICSVLGCVETKQITDAVNELSLILQRKGENFYQSSETSAKGLIEK
VTTELSTSIYQLINVYCNSFYADFQPVNVPRCTSYLNPGLPSHLSFTVYAAHNIPETWVH
RINFPLEIKSLPRESMLTVKLFGIACATNNANLLAWTCLPLFPKEKSILGSMLFSMTLQS
EPPVEMITPGVWDVSQPSPVTLQIDFPATGWEYMKPDSEENRSNLEEPLKECIKHIARLS
QKQTPLLLSEEKKRYLWFYRFYCNNENCSLPLVLGSAPGWDERTVSEMHTILRRWTFSQP
LEALGLLTSSFPDQEIRKVAVQQLDNLLNDELLEYLPQLVQAVKFEWNLESPLVQLLLHR
SLQSIQVAHRLYWLLKNAENEAYFKSWYQKLLAALQFCAGKALNDEFSKEQKLIKILGDI
GERVKSASDHQRQEVLKKEIGRLEEFFQDVNTCHLPLNPALCIKGIDHDACSYFTSNALP
LKITFINANLMGKNISIIFKAGDDLRQDMLVLQLIQVMDNIWLQEGLDMQMIIYRCLSTG
KDQGLVQMVPDAVTLAKIHRHSGLIGPLKENTIKKWFSQHNHLKADYEKALRNFFYSCAG
WCVVTFILGVCDRHNDNIMLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYF
ITEGGKNPQHFQDFVELCCRAYNIIRKHSQLLLNLLEMMLYAGLPELSGIQDLKYVYNNL
RPQDTDLEATSHFTKKIKESLECFPVKLNNLIHTLAQMSAISPAKSTSQTFPQESCLLST
TRSIERATILGFSKKSSNLYLIQVTHSNNETSLTEKSFEQFSKLHSQLQKQFASLTLPEF
PHWWHLPFTNSDHRRFRDLNHYMEQILNVSHEVTNSDCVLSFFLSEAVQQTVEESSPVYL
GEKFPDKKPKVQLVISYEDVKLTILVKHMKNIHLPDGSAPSAHVEFYLLPYPSEVRRRKT
KSVPKCTDPTYNEIVVYDEVTELQGHVLMLIVKSKTVFVGAINIRLCSVPLDKEKWYPLG
NSII
|
| External Links |
|---|
| GenBank ID Protein
| 120659792 |
| UniProtKB/Swiss-Prot ID
| O75747 |
| UniProtKB/Swiss-Prot Entry Name
| P3C2G_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC130277 |
| GeneCard ID
| PIK3C2G |
| GenAtlas ID
| PIK3C2G |
| HGNC ID
| HGNC:8973 |
| References |
|---|
| General References
| Not Available |