| Identification |
|---|
| HMDB Protein ID
| CDBP01062 |
| Secondary Accession Numbers
| Not Available |
| Name
| Prostacyclin synthase |
| Description
| Not Available |
| Synonyms
|
- Prostaglandin I2 synthase
|
| Gene Name
| PTGIS |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in monooxygenase activity |
| Specific Function
| Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).
|
| GO Classification
|
| Biological Process |
| cellular response to interleukin-6 |
| positive regulation of peroxisome proliferator activated receptor signaling pathway |
| negative regulation of nitric oxide biosynthetic process |
| cellular response to interleukin-1 |
| positive regulation of angiogenesis |
| xenobiotic metabolic process |
| negative regulation of NF-kappaB transcription factor activity |
| cellular response to hypoxia |
| prostaglandin biosynthetic process |
| positive regulation of apoptotic process |
| negative regulation of inflammatory response |
| Cellular Component |
| endoplasmic reticulum membrane |
| nucleus |
| caveola |
| extracellular space |
| integral to membrane |
| Function |
| metal ion binding |
| binding |
| catalytic activity |
| transition metal ion binding |
| electron carrier activity |
| iron ion binding |
| monooxygenase activity |
| heme binding |
| oxidoreductase activity |
| ion binding |
| cation binding |
| Molecular Function |
| electron carrier activity |
| monooxygenase activity |
| prostaglandin-I synthase activity |
| iron ion binding |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| heme binding |
|
| Cellular Location
|
- Endoplasmic reticulum membrane
- Single-pass membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Arachidonic Acid Metabolism |    |  | | Leukotriene C4 Synthesis Deficiency |    | Not Available | | Piroxicam Action Pathway |    | Not Available | | Acetylsalicylic Acid Action Pathway |    | Not Available | | Etodolac Action Pathway |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 20 |
| Locus
| 20q13.13 |
| SNPs
| PTGIS |
| Gene Sequence
|
>1503 bp
ATGGCTTGGGCCGCGCTCCTCGGCCTCCTGGCCGCACTGTTGCTGCTGCTGCTACTGAGC
CGCCGCCGCACGCGGCGACCTGGTGAGCCTCCCCTGGACCTGGGCAGCATCCCCTGGTTG
GGGTATGCCTTGGACTTTGGAAAAGATGCTGCCAGCTTCCTCACGAGGATGAAGGAGAAG
CACGGTGACATCTTTACTATACTGGTTGGGGGCAGGTATGTCACCGTTCTCCTGGACCCA
CACTCCTACGACGCGGTGGTGTGGGAGCCTCGCACCAGGCTCGACTTCCATGCCTATGCC
ATCTTCCTCATGGAGAGGATTTTTGATGTGCAGCTTCCACATTACAGCCCCAGTGATGAA
AAGGCCAGGATGAAACTGACTCTTCTCCACAGAGAGCTCCAGGCACTCACAGAAGCCATG
TATACCAACCTCCATGCAGTGCTGTTGGGCGATGCTACAGAAGCAGGCAGTGGCTGGCAC
GAGATGGGTCTCCTCGACTTCTCCTACAGCTTCCTGCTCAGAGCCGGCTACCTGACTCTT
TACGGAATTGAGGCGCTGCCACGCACCCATGAAAGCCAGGCCCAGGACCGCGTCCACTCA
GCTGATGTCTTCCACACCTTTCGCCAGCTCGACCGGCTGCTCCCCAAACTGGCCCGTGGC
TCCCTGTCAGTGGGGGACAAGGACCACATGTGCAGTGTCAAAAGTCGCCTGTGGAAGCTG
CTATCCCCAGCCAGGCTGGCCAGGCGGGCCCACCGGAGCAAATGGCTGGAGAGTTACCTG
CTGCACCTGGAGGAGATGGGTGTGTCAGAGGAGATGCAGGCACGGGCCCTGGTGCTGCAG
CTGTGGGCCACACAGGGGAATATGGGTCCCGCTGCCTTCTGGCTCCTGCTCTTCCTTCTC
AAGAATCCTGAAGCCCTGGCTGCTGTCCGCGGAGAGCTCGAGAGTATCCTTTGGCAAGCG
GAGCAGCCTGTCTCGCAGACGACCACTCTCCCACAGAAGGTTCTAGACAGCACACCTGTG
CTTGATAGCGTGCTGAGTGAGAGCCTCAGGCTTACAGCTGCCCCCTTCATCACCCGCGAG
GTTGTGGTGGACCTGGCCATGCCCATGGCAGACGGGAGAGAATTCAACCTGCGACGTGGT
GACCGCCTCCTCCTCTTCCCCTTCCTGAGCCCCCAGAGAGACCCAGAAATCTACACAGAC
CCAGAGGTATTTAAATACAACCGATTCCTGAACCCTGACGGATCAGAGAAGAAAGACTTT
TACAAGGATGGGAAACGGCTGAAGAATTACAACATGCCCTGGGGGGCGGGGCACAATCAC
TGCCTGGGGAGGAGTTATGCGGTCAACAGCATCAAACAATTTGTGTTCCTTGTGCTGGTG
CACTTGGACTTGGAGCTGATCAACGCAGATGTGGAGATCCCTGAGTTTGACCTCAGCAGG
TACGGCTTCGGTCTGATGCAGCCGGAACACGACGTGCCCGTCCGCTACCGCATCCGCCCA
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 500 |
| Molecular Weight
| 57103.385 |
| Theoretical pI
| 7.308 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Prostacyclin synthase
MAWAALLGLLAALLLLLLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEK
HGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDE
KARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTL
YGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKL
LSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLL
KNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITRE
VVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDF
YKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSR
YGFGLMQPEHDVPVRYRIRP
|
| External Links |
|---|
| GenBank ID Protein
| 537949 |
| UniProtKB/Swiss-Prot ID
| Q16647 |
| UniProtKB/Swiss-Prot Entry Name
| PTGIS_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| D38145 |
| GeneCard ID
| PTGIS |
| GenAtlas ID
| PTGIS |
| HGNC ID
| HGNC:9603 |
| References |
|---|
| General References
| Not Available |