| Identification |
|---|
| HMDB Protein ID
| CDBP01050 |
| Secondary Accession Numbers
| Not Available |
| Name
| Mitochondrial 2-oxoglutarate/malate carrier protein |
| Description
| Not Available |
| Synonyms
|
- OGCP
- Solute carrier family 25 member 11
|
| Gene Name
| SLC25A11 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in transporter activity |
| Specific Function
| Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism.
|
| GO Classification
|
| Biological Process |
| small molecule metabolic process |
| gluconeogenesis |
| Cellular Component |
| mitochondrial inner membrane |
| integral to plasma membrane |
| Component |
| membrane |
| cell part |
| organelle membrane |
| organelle inner membrane |
| mitochondrial inner membrane |
| Function |
| binding |
| transporter activity |
| Molecular Function |
| oxoglutarate:malate antiporter activity |
| Process |
| establishment of localization |
| transport |
| transmembrane transport |
|
| Cellular Location
|
- Mitochondrion inner membrane
- Multi-pass membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Malate-Aspartate Shuttle |    | Not Available | | Gluconeogenesis |    |  | | Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease |    | Not Available | | Phosphoenolpyruvate carboxykinase deficiency 1 (PEPCK1) |    | Not Available | | Fructose-1,6-diphosphatase deficiency |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| 17p13.3 |
| SNPs
| SLC25A11 |
| Gene Sequence
|
>945 bp
ATGGCGGCGACGGCGAGTGCCGGGGCCGGCGGGATAGACGGGAAGCCCCGTACCTCCCCT
AAGTCCGTCAAGTTCCTGTTTGGGGGCCTGGCCGGGATGGGAGCTACAGTTTTTGTCCAG
CCCCTGGACCTGGTGAAGAACCGGATGCAGTTGAGCGGGGAAGGGGCCAAGACTCGAGAG
TACAAAACCAGCTTCCATGCCCTCACCAGTATCCTGAAGGCAGAAGGCCTGAGGGGCATT
TACACTGGGCTGTCGGCTGGCCTGCTGCGTCAGGCCACCTACACCACTACCCGCCTTGGC
ATCTATACCGTGCTGTTTGAGCGCCTGACTGGGGCTGATGGTACTCCCCCTGGCTTTCTG
CTGAAGGCTGTGATTGGCATGACCGCAGGTGCCACTGGTGCCTTTGTGGGAACACCAGCC
GAAGTGGCTCTTATCCGCATGACTGCCGATGGCCGGCTTCCAGCTGACCAGCGCCGTGGC
TACAAAAATGTGTTTAACGCCCTGATTCGAATCACCCGGGAAGAGGGTGTCCTCACACTG
TGGCGGGGCTGCATCCCTACCATGGCTCGGGCCGTCGTCGTCAATGCTGCCCAGCTCGCC
TCCTACTCCCAATCCAAGCAGTTCTTACTGGACTCAGGCTACTTCTCTGACAACATCTTG
TGCCACTTCTGTGCCAGCATGATCAGCGGTCTTGTCACCACTGCTGCCTCCATGCCTGTG
GACATTGCCAAGACCCGAATCCAGAACATGCGGATGATTGATGGGAAGCCGGAATACAAG
AACGGGCTGGACGTGCTGTTCAAAGTTGTCCGCTACGAGGGCTTCTTCAGCCTGTGGAAG
GGCTTCACGCCGTACTATGCCCGCCTGGGCCCCCACACCGTCCTCACCTTCATCTTCTTG
GAGCAGATGAACAAGGCCTACAAGCGTCTCTTCCTCAGTGGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 314 |
| Molecular Weight
| 34061.405 |
| Theoretical pI
| 9.908 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Mitochondrial 2-oxoglutarate/malate carrier protein
MAATASAGAGGIDGKPRTSPKSVKFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTRE
YKTSFHALTSILKAEGLRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFL
LKAVIGMTAGATGAFVGTPAEVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTL
WRGCIPTMARAVVVNAAQLASYSQSKQFLLDSGYFSDNILCHFCASMISGLVTTAASMPV
DIAKTRIQNMRMIDGKPEYKNGLDVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFL
EQMNKAYKRLFLSG
|
| External Links |
|---|
| GenBank ID Protein
| 3387911 |
| UniProtKB/Swiss-Prot ID
| Q02978 |
| UniProtKB/Swiss-Prot Entry Name
| M2OM_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF070548 |
| GeneCard ID
| SLC25A11 |
| GenAtlas ID
| SLC25A11 |
| HGNC ID
| HGNC:10981 |
| References |
|---|
| General References
| Not Available |