| Identification |
|---|
| HMDB Protein ID
| CDBP01048 |
| Secondary Accession Numbers
| Not Available |
| Name
| Monocarboxylate transporter 5 |
| Description
| Not Available |
| Synonyms
|
- MCT 4
- MCT 5
- Monocarboxylate transporter 4
- Solute carrier family 16 member 4
|
| Gene Name
| SLC16A4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in transmembrane transport |
| Specific Function
| Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate |
| GO Classification
|
| Process |
| establishment of localization |
| transport |
| transmembrane transport |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1p13.3 |
| SNPs
| SLC16A4 |
| Gene Sequence
|
>1464 bp
ATGCTGAAGAGGGAGGGGAAGGTCCAACCTTACACTAAAACCCTGGATGGAGGATGGGGA
TGGATGATTGTGATTCATTTTTTCCTGGTGAATGTGTTTGTGATGGGGATGACCAAGACT
TTTGCAATTTTCTTTGTGGTCTTTCAAGAAGAGTTTGAAGGCACCTCAGAGCAAATTGGT
TGGATTGGATCCATCATGTCATCTCTTCGTTTTTGTGCAGGTCCCCTGGTTGCTATTATT
TGTGACATACTTGGAGAGAAAACTACCTCCATTCTTGGGGCTTTCGTTGTTACTGGTGGA
TATCTGATCAGCAGCTGGGCCACAAGTATTCCTTTTCTTTGTGTGACTATGGGACTTCTA
CCCGGTTTGGGTTCTGCTTTCTTATACCAAGTGGCTGCTGTGGTAACTACCAAATACTTC
AAAAAACGATTGGCTCTTTCTACAGCTATTGCCCGTTCTGGGATGGGACTGACTTTTCTT
TTGGCACCCTTTACAAAATTCCTGATAGATCTGTATGACTGGACAGGAGCCCTTATATTA
TTTGGAGCTATCGCATTGAATTTGGTGCCTTCTAGTATGCTCTTAAGACCCATCCATATC
AAAAGTGAGAACAATTCTGGTATTAAAGATAAAGGCAGCAGTTTGTCTGCACATGGTCCA
GAGGCACATGCAACAGAAACACACTGCCATGAGACAGAAGAGTCTACCATCAAGGACAGT
ACTACGCAGAAGGCTGGACTACCTAGCAAAAATTTAACAGTCTCACAAAATCAAAGTGAA
GAGTTCTACAATGGGCCTAACAGGAACAGACTGTTATTAAAGAGTGATGAAGAAAGTGAT
AAGGTTATTTCGTGGAGCTGCAAACAACTGTTTGACATTTCTCTCTTTAGAAATCCTTTC
TTCTACATATTTACTTGGTCTTTTCTCCTCAGTCAGTTAGCATACTTCATCCCTACCTTT
CACCTGGTAGCCAGAGCCAAAACACTGGGGATTGACATCATGGATGCCTCTTACCTTGTT
TCTGTAGCAGGTATCCTTGAGACGGTCAGTCAGATTATTTCTGGATGGGTTGCTGATCAA
AACTGGATTAAGAAGTATCATTACCACAAGTCTTACCTCATCCTCTGCGGCATCACTAAC
CTGCTTGCTCCTTTAGCCACCACATTTCCACTACTTATGACCTACACCATCTGCTTTGCC
ATCTTTGCTGGTGGTTACCTGGCATTGATACTGCCTGTACTGGTTGATCTGTGTAGGAAT
TCTACAGTAAACAGGTTTTTGGGACTTGCCAGTTTCTTTGCTGGGATGGCTGTCCTTTCT
GGACCACCTATAGCAGGCTGGTTATATGATTATACCCAGACATACAATGGCTCTTTCTAC
TTCTCTGGCATATGCTATCTCCTCTCTTCAGTTTCCTTTTTTTTTGTACCATTGGCCGAA
AGATGGAAAAACAGTCTGACCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 487 |
| Molecular Weight
| 54021.4 |
| Theoretical pI
| 8.13 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["17-37", "60-80", "88-108", "110-129", "144-164", "175-195", "300-320", "338-358", "373-393", "395-415", "426-446", "459-479"]
|
| Protein Sequence
|
>Monocarboxylate transporter 5
MLKREGKVQPYTKTLDGGWGWMIVIHFFLVNVFVMGMTKTFAIFFVVFQEEFEGTSEQIG
WIGSIMSSLRFCAGPLVAIICDILGEKTTSILGAFVVTGGYLISSWATSIPFLCVTMGLL
PGLGSAFLYQVAAVVTTKYFKKRLALSTAIARSGMGLTFLLAPFTKFLIDLYDWTGALIL
FGAIALNLVPSSMLLRPIHIKSENNSGIKDKGSSLSAHGPEAHATETHCHETEESTIKDS
TTQKAGLPSKNLTVSQNQSEEFYNGPNRNRLLLKSDEESDKVISWSCKQLFDISLFRNPF
FYIFTWSFLLSQLAYFIPTFHLVARAKTLGIDIMDASYLVSVAGILETVSQIISGWVADQ
NWIKKYHYHKSYLILCGITNLLAPLATTFPLLMTYTICFAIFAGGYLALILPVLVDLCRN
STVNRFLGLASFFAGMAVLSGPPIAGWLYDYTQTYNGSFYFSGICYLLSSVSFFFVPLAE
RWKNSLT
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| O15374 |
| UniProtKB/Swiss-Prot Entry Name
| MOT5_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| U59185 |
| GeneCard ID
| SLC16A4 |
| GenAtlas ID
| SLC16A4 |
| HGNC ID
| HGNC:10925 |
| References |
|---|
| General References
| Not Available |