Showing Protein Monocarboxylate transporter 6 (CDBP01047)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP01047
Secondary Accession Numbers Not Available
Name Monocarboxylate transporter 6
Description Not Available
Synonyms
  1. MCT 5
  2. MCT 6
  3. Monocarboxylate transporter 5
  4. Solute carrier family 16 member 5
Gene Name SLC16A5
Protein Type Enzyme
Biological Properties
General Function Involved in transmembrane transport
Specific Function Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate
GO Classification
Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
substrate-specific transmembrane transporter activity
transporter activity
organic acid transmembrane transporter activity
carboxylic acid transmembrane transporter activity
monocarboxylic acid transmembrane transporter activity
secondary active monocarboxylate transmembrane transporter activity
transmembrane transporter activity
Process
establishment of localization
transport
organic anion transport
transmembrane transport
anion transport
ion transport
Cellular Location
  1. Cell membrane
  2. Multi-pass membrane protein
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 17q25.1
SNPs SLC16A5
Gene Sequence 
>1518 bp
ATGCCCCAGGCCCTGGAGCGTGCAGATGGCAGCTGGGCCTGGGTGGTGCTGCTGGCCACC
ATGGTGACCCAGGGCCTCACCCTGGGCTTCCCCACGTGTATCGGCATCTTCTTCACTGAA
CTGCAATGGGAGTTCCAGGCCAGCAACAGCGAGACCTCTTGGTTCCCCTCCATCCTCACG
GCTGTGCTCCACATGGCAGGGCCCCTGTGCAGCATCCTGGTGGGACGCTTCGGCTGCCGA
GTGACCGTGATGCTGGGGGGCGTGCTGGCCAGCCTGGGCATGGTGGCCAGCTCCTTCTCT
CACAACCTCAGCCAGCTCTACTTCACAGCAGGATTCATCACAGGCCTGGGCATGTGCTTC
AGCTTCCAGTCAAGCATCACGGTGCTGGGCTTCTACTTTGTCCGCCGGCGGGTGCTGGCC
AACGCGCTGGCCTCGATGGGCGTCTCCCTGGGCATCACCCTCTGGCCGCTGCTCTCCCGT
TACCTTCTGGAGAACCTGGGCTGGAGGGGTACCTTCCTTGTCTTCGGCGGGATCTTTCTC
CACTGCTGCATCTGCGGGGCCATCATAAGGCCTGTGGCCACCAGTGTGGCCCCTGAGACC
AAAGAATGTCCCCCGCCACCTCCCGAGACACCTGCACTTGGCTGCCTGGCTGCATGCGGC
CGGACCATCCAGCGCCACCTGGCCTTCGACATCCTGCGGCACAACACAGGCTACTGCGTG
TACATACTGGGTGTGATGTGGTCCGTCCTGGGCTTCCCACTGCCACAAGTCTTCCTGGTG
CCATATGCCATGTGGCACAGCGTGGACGAGCAGCAGGCAGCCCTCCTCATCTCCATCATC
GGCTTCAGCAACATCTTCCTGAGGCCCCTAGCCGGGCTGATGGCAGGACGGCCGGCCTTT
GCTAGCCACCGCAAGTACCTGTTCAGCCTGGCACTCCTGCTCAATGGGCTCACTAACCTG
GTGTGTGCGGCATCAGGTGACTTCTGGGTGCTCGTGGGCTACTGCCTGGCGTACAGCGTG
TCCATGAGTGGCATCGGCGCCCTCATCTTCCAGGTTCTCATGGACATCGTCCCCATGGAT
CAGTTCCCCAGAGCCCTGGGACTCTTCACTGTCCTGGACGGCCTTGCTTTCCTCATCTCC
CCACCACTGGCCGGGTTGCTCCTGGACGCCACCAACAACTTTAGCTATGTTTTCTACATG
TCCAGCTTCTTCCTCATCTCAGCTGCCCTCTTCATGGGTGGCAGCTTCTACGCCCTGCAG
AAGAAGGAGCAAGGCAAGCAGGCTGTCGCGGCGGATGCCCTGGAGCGGGATCTTTTCTTG
GAAGCCAAAGACGGTCCTGGGAAGCAACGGTCCCCTGAGATCATGTGCCAGTCTTCCCGC
CAGCCACGTCCAGCTGGCGTCAATAAGCATCTTTGGGGATGTCCTGCCTCCTCCAGGACC
AGCCATGAGTGGCTCTTATGGCCAAAGGCGGTACTGCAGGCCAAGCAAACGGCTCTGGGC
TGGAATAGCCCTACCTGA
Protein Properties
Number of Residues 505
Molecular Weight 54993.0
Theoretical pI 8.28
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["18-38", "54-74", "81-101", "111-131", "138-158", "172-192", "240-260", "275-295", "306-326", "330-350", "368-388", "397-417"]
Protein Sequence 
>Monocarboxylate transporter 6
MPQALERADGSWAWVVLLATMVTQGLTLGFPTCIGIFFTELQWEFQASNSETSWFPSILT
AVLHMAGPLCSILVGRFGCRVTVMLGGVLASLGMVASSFSHNLSQLYFTAGFITGLGMCF
SFQSSITVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLENLGWRGTFLVFGGIFL
HCCICGAIIRPVATSVAPETKECPPPPPETPALGCLAACGRTIQRHLAFDILRHNTGYCV
YILGVMWSVLGFPLPQVFLVPYAMWHSVDEQQAALLISIIGFSNIFLRPLAGLMAGRPAF
ASHRKYLFSLALLLNGLTNLVCAASGDFWVLVGYCLAYSVSMSGIGALIFQVLMDIVPMD
QFPRALGLFTVLDGLAFLISPPLAGLLLDATNNFSYVFYMSSFFLISAALFMGGSFYALQ
KKEQGKQAVAADALERDLFLEAKDGPGKQRSPEIMCQSSRQPRPAGVNKHLWGCPASSRT
SHEWLLWPKAVLQAKQTALGWNSPT
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID O15375
UniProtKB/Swiss-Prot Entry Name MOT6_HUMAN
PDB IDs Not Available
GenBank Gene ID U59299
GeneCard ID SLC16A5
GenAtlas ID SLC16A5
HGNC ID HGNC:10926
References
General References Not Available