| Identification |
|---|
| HMDB Protein ID
| CDBP01044 |
| Secondary Accession Numbers
| Not Available |
| Name
| Monocarboxylate transporter 7 |
| Description
| Not Available |
| Synonyms
|
- MCT 6
- MCT 7
- Monocarboxylate transporter 6
- Solute carrier family 16 member 6
|
| Gene Name
| SLC16A6 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in transmembrane transport |
| Specific Function
| Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate |
| GO Classification
|
| Process |
| establishment of localization |
| transport |
| transmembrane transport |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 17q24.2 |
| SNPs
| SLC16A6 |
| Gene Sequence
|
>1572 bp
ATGACCCAAAATAAATTAAAGCTTTGTTCCAAAGCCAATGTGTATACTGAAGTGCCTGAT
GGAGGATGGGGCTGGGCGGTAGCTGTTTCATTTTTCTTCGTTGAAGTCTTCACCTACGGC
ATCATCAAGACATTTGGTGTCTTCTTTAATGACTTAATGGACAGTTTTAATGAATCCAAT
AGCAGGATCTCATGGATAATCTCAATCTGTGTGTTTGTCTTAACATTTTCAGCTCCCCTC
GCCACAGTCCTGAGCAATCGTTTCGGACACCGTCTGGTAGTGATGTTGGGGGGGCTACTT
GTCAGCACCGGGATGGTGGCCGCCTCCTTCTCACAAGAGGTTTCTCATATGTACGTCGCC
ATCGGCATCATCTCTGGTCTGGGATACTGCTTTAGTTTTCTCCCAACTGTAACCATCCTA
TCACAATATTTTGGCAAAAGACGTTCCATAGTCACTGCAGTTGCTTCCACAGGAGAATGT
TTCGCTGTGTTTGCTTTCGCACCAGCAATCATGGCTCTGAAGGAGCGCATTGGCTGGAGA
TACAGCCTCCTCTTCGTGGGCCTACTACAGTTAAACATTGTCATCTTCGGAGCACTGCTC
AGACCCATCTTTATCAGAGGACCAGCGTCACCGAAAATAGTCATCCAGGAAAATCGGAAA
GAAGCGCAGTATATGCTTGAAAATGAGAAAACACGAACCTCAATAGACTCCATTGACTCA
GGAGTAGAACTAACTACCTCACCTAAAAATGTGCCTACTCACACTAACCTGGAACTGGAG
CCGAAGGCCGACATGCAGCAGGTCCTGGTGAAGACCAGCCCCAGGCCAAGCGAAAAGAAA
GCCCCGCTATTAGACTTCTCCATTTTGAAAGAGAAAAGTTTTATTTGTTATGCATTATTT
GGTCTCTTTGCAACACTGGGATTCTTTGCACCTTCCTTGTACATCATTCCTCTGGGCATT
AGTCTGGGCATTGACCAGGACCGCGCTGCTTTTTTATTATCTACGATGGCCATTGCAGAA
GTTTTCGGAAGGATCGGAGCTGGTTTTGTCCTCAACAGGGAGCCCATTCGTAAGATTTAC
ATTGAGCTCATCTGCGTCATCTTATTGACTGTGTCTCTGTTTGCCTTTACTTTTGCTACT
GAATTCTGGGGTCTAATGTCATGCAGCATATTTTTTGGGTTTATGGTTGGAACAATAGGA
GGGACTCACATTCCACTGCTTGCTGAGGATGATGTCGTGGGCATTGAGAAGATGTCTTCT
GCAGCTGGGGTCTACATCTTCATTCAGAGCATAGCAGGACTGGCTGGACCGCCCCTTGCA
GGTTTGTTGGTGGACCAAAGTAAGATCTACAGCAGGGCCTTCTACTCCTGCGCAGCTGGC
ATGGCCCTGGCTGCTGTGTGCCTCGCCCTGGTGAGACCGTGTAAGATGGGACTGTGCCAG
CATCATCACTCAGGTGAAACAAAGGTAGTGAGCCATCGTGGGAAGACTTTACAGGACATA
CCTGAAGACTTTCTGGAAATGGATCTTGCAAAAAATGAGCACAGAGTTCACGTGCAAATG
GAGCCGGTATGA
|
| Protein Properties |
|---|
| Number of Residues
| 523 |
| Molecular Weight
| 57392.8 |
| Theoretical pI
| 7.88 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["22-42", "63-83", "92-112", "119-139", "150-170", "185-205", "300-320", "331-351", "359-379", "382-402", "424-444", "453-473"]
|
| Protein Sequence
|
>Monocarboxylate transporter 7
MTQNKLKLCSKANVYTEVPDGGWGWAVAVSFFFVEVFTYGIIKTFGVFFNDLMDSFNESN
SRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVSTGMVAASFSQEVSHMYVA
IGIISGLGYCFSFLPTVTILSQYFGKRRSIVTAVASTGECFAVFAFAPAIMALKERIGWR
YSLLFVGLLQLNIVIFGALLRPIFIRGPASPKIVIQENRKEAQYMLENEKTRTSIDSIDS
GVELTTSPKNVPTHTNLELEPKADMQQVLVKTSPRPSEKKAPLLDFSILKEKSFICYALF
GLFATLGFFAPSLYIIPLGISLGIDQDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIY
IELICVILLTVSLFAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAEDDVVGIEKMSS
AAGVYIFIQSIAGLAGPPLAGLLVDQSKIYSRAFYSCAAGMALAAVCLALVRPCKMGLCQ
HHHSGETKVVSHRGKTLQDIPEDFLEMDLAKNEHRVHVQMEPV
|
| External Links |
|---|
| GenBank ID Protein
| 40675572 |
| UniProtKB/Swiss-Prot ID
| O15403 |
| UniProtKB/Swiss-Prot Entry Name
| MOT7_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC064832 |
| GeneCard ID
| SLC16A6 |
| GenAtlas ID
| SLC16A6 |
| HGNC ID
| HGNC:10927 |
| References |
|---|
| General References
| Not Available |