Cannabis Compound Database: Showing Protein Monocarboxylate transporter 3 (CDBP01042)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP01042

Secondary Accession Numbers

Not Available

Name

Monocarboxylate transporter 3

Description

Not Available

Synonyms

MCT 3
Solute carrier family 16 member 8

Gene Name

SLC16A8

Protein Type

Enzyme

Biological Properties

General Function

Involved in transmembrane transport

Specific Function

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate

GO Classification

Component
integral to membrane
cell part
membrane part
intrinsic to membrane
Function
transmembrane transporter activity
substrate-specific transmembrane transporter activity
transporter activity
organic acid transmembrane transporter activity
carboxylic acid transmembrane transporter activity
monocarboxylic acid transmembrane transporter activity
secondary active monocarboxylate transmembrane transporter activity
Process
establishment of localization
transport
organic anion transport
transmembrane transport
anion transport
ion transport

Cellular Location

Cell membrane
Multi-pass membrane protein

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:2

Locus

22q12.3-q13.2

SNPs

SLC16A8

Gene Sequence

>1515 bp
ATGGGCGCTGGCGGCCCCCGGCGGGGCGAGGGCCCCCCAGACGGCGGCTGGGGCTGGGTG
GTGCTGGGCGCCTGCTTTGTGGTCACCGGCTTCGCCTACGGCTTCCCCAAAGCCGTGAGC
GTCTTCTTCCGCGCGCTCATGCGCGACTTCGACGCCGGCTACAGCGACACGGCCTGGGTG
TCCTCCATCATGCTAGCCATGCTCTACGGCACGGGCCCCGTGTCCAGCATCCTCGTGACC
CGCTTTGGCTGTCGCCCGGTGATGCTGGCGGGTGGGCTGCTGGCTTCCGCGGGCATGATC
CTAGCTTCCTTTGCCACGCGCCTTCTGGAGCTCTACCTGACCGCTGGGGTGCTCACAGGC
CTGGGCCTGGCCCTCAACTTCCAGCCGTCGCTCATCATGCTGGGGCTGTACTTCGAGCGG
CGGCGGCCTCTGGCCAACGGGCTGGCGGCGGCGGGCAGCCCCGTGTTCCTGTCCGCGCTG
TCGCCGCTCGGCCAGCAGCTGCTGGAGCGCTTCGGCTGGCGCGGCGGCTTCCTGCTGCTC
GGCGGGCTCCTGCTGCACTGCTGCGCCTGCGGGGCTGTCATGAGGCCGCCGCCCGGGCCG
GGCCCGCGACCGCGCAGGGACAGCGCCGGCGACCGCGCCGGGGACGCTCCGGGCGAGGCG
GAGGCTGACGGTGCGGGGCTGCAGCTGCGCGAGGCATCCCCCTGGGTCCGGCCCCGCCGG
CGCCTGCTGGACTTGGCAGTGTGCACCGACCGCGCCTTCGCCGTGTACGCCGTCACCAAG
TTCCTGATGGCGCTCGGGCTCTTCGTCCCCGCCATCCTGCTGGTGAACTACGCCAAGGAC
GCGGGCGTGCCCGACACCGACGCCGCCTTCCTGCTGTCCATCGTGGGCTTCGTGGACATC
GTGGCGCGCCCGGCGTGCGGCGCCCTGGCGGGCCTGGCGCGTCTGCGGCCGCACGTCCCG
TATCTGTTCAGCCTGGCCCTGCTGGCCAATGGGCTCACAGACCTGAGCAGCGCACGCGCG
CGCTCCTACGGCGCCCTCGTCGCCTTCTGCGTCGCCTTCGGCCTCTCCTACGGCATGGTG
GGCGCGCTGCAGTTCGAGGTGCTCATGGCGGCTGTGGGCGCGCCCCGCTTCCCCAGTGCG
CTGGGCCTGGTGTTGCTCGTGGAGGCCGCGGCTGTGCTCATCGGACCGCCCTCTGCCGGC
CGCCTGGTGGATGCGTTGAAGAACTATGAGATCATCTTCTACCTGGCCGGCTCTGAGGTG
GCCCTGGCTGGGGTCTTCATGGCTGTCGCCACCAACTGCTGCCTGCGTTGTGCTAAAGCT
GCCCCGTCAGGCCCAGGCACTGAGGGCGGAGCCAGTGACACTGAGGACGCTGAGGCTGAA
GGGGACTCTGAGCCCCTGCCTGTTGTTGCAGAGGAACCCGGCAACCTGGAGGCCCTGGAG
GTGCTCAGCGCCCGGGGCGAGCCCACAGAACCAGAAATAGAGGCGAGGCCGAGGCTGGCT
GCCGAGTCTGTATAA

Protein Properties

Number of Residues

504

Molecular Weight

52318.2

Theoretical pI

5.32

Pfam Domain Function

MFS_1 (PF07690 )

Signals

["None"]

Transmembrane Regions

["15-35", "59-79", "86-106", "116-136", "144-164", "173-193", "255-275", "290-310", "319-335", "343-363", "377-397", "411-431"]

Protein Sequence

>Monocarboxylate transporter 3
MGAGGPRRGEGPPDGGWGWVVLGACFVVTGFAYGFPKAVSVFFRALMRDFDAGYSDTAWV
SSIMLAMLYGTGPVSSILVTRFGCRPVMLAGGLLASAGMILASFATRLLELYLTAGVLTG
LGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSALSPLGQQLLERFGWRGGFLLL
GGLLLHCCACGAVMRPPPGPGPRPRRDSAGDRAGDAPGEAEADGAGLQLREASPRVRPRR
RLLDLAVCTDRAFAVYAVTKFLMALGLFVPAILLVNYAKDAGVPDTDAAFLLSIVGFVDI
VARPACGALAGLARLRPHVPYLFSLALLANGLTDLSSARARSYGALVAFCVAFGLSYGMV
GALQFEVLMAAVGAPRFPSALGLVLLVEAAAVLIGPPSAGRLVDVLKNYEIIFYLAGSEV
ALAGVFMAVATNCCLRCAKAAPSGPGTEGGASDTEDAEAEGDSEPLPVVAEEPGNLEALE
VLSARGEPTEPEIEARPRLAAESV

External Links

GenBank ID Protein

6103363

UniProtKB/Swiss-Prot ID

O95907

UniProtKB/Swiss-Prot Entry Name

MOT3_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AF132610

GeneCard ID