Showing Protein Uridine diphosphate glucose pyrophosphatase (CDBP01031)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 4 compounds
Identification
HMDB Protein ID CDBP01031
Secondary Accession Numbers Not Available
Name Uridine diphosphate glucose pyrophosphatase
Description Not Available
Synonyms
  1. Nucleoside diphosphate-linked moiety X motif 14
  2. Nudix motif 14
  3. UDPG pyrophosphatase
  4. UGPPase
Gene Name NUDT14
Protein Type Enzyme
Biological Properties
General Function Involved in hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Specific Function Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose.
GO Classification
Cellular Component
cytoplasm
Function
ion binding
cation binding
metal ion binding
binding
catalytic activity
hydrolase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Molecular Function
UDP-sugar diphosphatase activity
metal ion binding
Cellular Location
  1. Cytoplasm
Pathways
Gene Properties
Chromosome Location 14
Locus 14q32.33
SNPs NUDT14
Gene Sequence 
>669 bp
ATGGAGCGCATCGAGGGGGCGTCCGTGGGCCGCTGCGCCGCCTCACCCTACCTGCGGCCG
CTCACGCTGCATTACCGCCAGAATGGTGCCCAGAAGTCCTGGGACTTCATGAAGACGCAT
GACAGCGTGACCGTTCTCTTATTCAACTCTTCTCGGAGGAGCCTGGTGTTGGTGAAGCAG
TTCCGGCCAGCTGTGTATGCGGGTGAGGTGGAGCGCCGCTTCCCAGGGTCCCTAGCAGCT
GTAGACCAGGACGGGCCTCGGGAGCTACAGCCAGCCCTGCCCGGCTCAGCGGGGGTGACA
GTTGAGCTGTGTGCCGGCCTCGTGGACCAGCCTGGGCTCTCGCTGGAGGAAGTGGCTTGC
AAGGAGGCTTGGGAGGAGTGTGGCTACCACTTGGCCCCCTCTGATCTGCGCCGGGTCGCC
ACATACTGGTCTGGAGTGGGACTGACTGGCTCCAGACAGACCATGTTCTACACAGAGGTG
ACAGATGCCCAGCGTAGCGGTCCAGGTGGGGGCCTGGTGGAGGAGGGTGAGCTCATTGAG
GTGGTGCACCTGCCCCTGGAAGGCGCCCAGGCCTTTGCAGACGACCCGGACATCCCCAAG
ACCCTCGGCGTCATCTTTGGTGTCTCATGGTTCCTCAGCCAGGTGGCCCCCAACCTGGAT
CTCCAGTGA
Protein Properties
Number of Residues 222
Molecular Weight 24118.085
Theoretical pI 5.049
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Uridine diphosphate glucose pyrophosphatase
MERIEGASVGRCAASPYLRPLTLHYRQNGAQKSWDFMKTHDSVTVLLFNSSRRSLVLVKQ
FRPAVYAGEVERRFPGSLAAVDQDGPRELQPALPGSAGVTVELCAGLVDQPGLSLEEVAC
KEAWEECGYHLAPSDLRRVATYWSGVGLTGSRQTMFYTEVTDAQRSGPGGGLVEEGELIE
VVHLPLEGAQAFADDPDIPKTLGVIFGVSWFLSQVAPNLDLQ
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID O95848
UniProtKB/Swiss-Prot Entry Name NUD14_HUMAN
PDB IDs
GenBank Gene ID AB087802
GeneCard ID NUDT14
GenAtlas ID NUDT14
HGNC ID HGNC:20141
References
General References Not Available