| Identification |
|---|
| HMDB Protein ID
| CDBP01020 |
| Secondary Accession Numbers
| Not Available |
| Name
| Gamma-enolase |
| Description
| Not Available |
| Synonyms
|
- 2-phospho-D-glycerate hydro-lyase
- Enolase 2
- NSE
- Neural enolase
- Neuron-specific enolase
|
| Gene Name
| ENO2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in magnesium ion binding |
| Specific Function
| Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity).
|
| GO Classification
|
| Biological Process |
| gluconeogenesis |
| response to estradiol stimulus |
| small molecule metabolic process |
| glycolysis |
| response to drug |
| Cellular Component |
| cytosol |
| phosphopyruvate hydratase complex |
| photoreceptor inner segment |
| plasma membrane |
| perikaryon |
| Component |
| macromolecular complex |
| protein complex |
| phosphopyruvate hydratase complex |
| Function |
| lyase activity |
| carbon-oxygen lyase activity |
| hydro-lyase activity |
| phosphopyruvate hydratase activity |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| magnesium ion binding |
| Molecular Function |
| magnesium ion binding |
| phosphopyruvate hydratase activity |
| Process |
| metabolic process |
| small molecule metabolic process |
| alcohol metabolic process |
| monosaccharide metabolic process |
| hexose metabolic process |
| glucose metabolic process |
| glucose catabolic process |
| glycolysis |
|
| Cellular Location
|
- Cell membrane
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Glycolysis / Gluconeogenesis | Not Available |  | | RNA degradation | Not Available |  | | HIF-1 signaling pathway | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 12 |
| Locus
| 12p13 |
| SNPs
| ENO2 |
| Gene Sequence
|
>1299 bp
TCCATACAGAAGATCTGGGCCCGGGAGATCCTGGACTCCCGTGGGAACCCCACAGTGGAG
GTGGATCTCTATACTGCCAAAGGTCTTTTCCGGGCTGCAGTGCCCAGTGGAGCCTCTACG
GGCATCTATGAGGCCCTGGAGCTGAGGGATGGAGACAAACAGCGTTACTTAGGCAAAGGT
GTCCTGAAGGCAGTGGACCACATCAACTCCACCATCGCGCCAGCCCTCATCAGCTCAGGT
CTCTCTGTGGTGGAGCAAGAGAAGCTGGACAACCTGATGCTGGAGTTGGATGGGACTGAG
AACAAATCCAAGTTTGGGGCCAATGCCATCCTGGGTGTGTCTCTGGCCGTGTGTAAGGCA
GGGGCAGCTGAGCGGGAACTGCCCCTGTATCGCCACATTGCTCAGCTGGCCGGGAACTCA
GACCTCATCCTGCCTGTGCCGGCCTTCAACGTGATCAATGGTGGCTCTCATGCTGGCAAC
AAGCTGGCCATGCAGGAGTTCATGATCCTCCCAGTGGGAGCTGAGAGCTTTCGGGATGCC
ATGCGACTAGGTGCAGAGGTCTACCATACTCTCAAGGGAGTCATCAAGGACAAATACGGC
AAGGATGCCACCAATGTGGGGGATGAAGGTGGCTTTGCCCCCAATATCCTGGAGAACAGT
GAAGCCTTGGAGCTGGTTAAGGAAGCCATCGACAAGGCTGGCTACACGGAAAAAATGGTT
ATTGGCATGGATGTTGCTGCCTCAGAGTTTTATCGTGATGGCAAATATGACTTGGACTTC
AAGTCTCCCACTGATCCTTCCCGATACATCACTGGGGACCAGCTGGGGGCACTCTACCAG
GACTTTGTCAGGGACTATCCTGTGGTCTCCATTGAGGACCCATTTGACCAGGATGATTGG
GCTGCCTGGTCCAAGTTCACAGCCAATGTAGGGATCCAGATTGTGGGTGATGACCTGACA
GTGACCAACCCAAAACGTATTGAGCGGGCAGTGGAAGAAAAGGCCTGCAACTGTCTGCTG
CTCAAGGTCAACCAGATCGGCTCGGTCACTGAAGCCATCCAAGCGTGCAAGCTGGCCCAG
GAGAATGGCTGGGGGGTCATGGTGAGTCATCGCTCAGGAGAGACTGAGGACACATTCATT
GCTGACCTGGTGGTGGGGCTGTGCACAGGCCAGATCAAGACTGGTGCCCCGTGCCGTTCT
GAACGTCTGGCTAAATACAATCAGCTCATGAGAATTGAGGAAGAGCTGGGGGATGAAGCT
CGCTTTGCCGGACATAACTTCCGTAATCCCAGTGTGCTG
|
| Protein Properties |
|---|
| Number of Residues
| 434 |
| Molecular Weight
| 47268.125 |
| Theoretical pI
| 5.029 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Gamma-enolase
MSIEKIWAREILDSRGNPTVEVDLYTAKGLFRAAVPSGASTGIYEALELRDGDKQRYLGK
GVLKAVDHINSTIAPALISSGLSVVEQEKLDNLMLELDGTENKSKFGANAILGVSLAVCK
AGAAERELPLYRHIAQLAGNSDLILPVPAFNVINGGSHAGNKLAMQEFMILPVGAESFRD
AMRLGAEVYHTLKGVIKDKYGKDATNVGDEGGFAPNILENSEALELVKEAIDKAGYTEKI
VIGMDVAASEFYRDGKYDLDFKSPTDPSRYITGDQLGALYQDFVRDYPVVSIEDPFDQDD
WAAWSKFTANVGIQIVGDDLTVTNPKRIERAVEEKACNCLLLKVNQIGSVTEAIQACKLA
QENGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLMRIEEELGDE
ARFAGHNFRNPSVL
|
| External Links |
|---|
| GenBank ID Protein
| 930063 |
| UniProtKB/Swiss-Prot ID
| P09104 |
| UniProtKB/Swiss-Prot Entry Name
| ENOG_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| X13120 |
| GeneCard ID
| ENO2 |
| GenAtlas ID
| ENO2 |
| HGNC ID
| HGNC:3353 |
| References |
|---|
| General References
| Not Available |