Cannabis Compound Database: Showing Protein Poly(A) polymerase gamma (CDBP01015)

Identification Biological properties Gene properties Protein properties External links References XML Show 2 compounds

Identification

HMDB Protein ID

CDBP01015

Secondary Accession Numbers

Not Available

Name

Poly(A) polymerase gamma

Description

Not Available

Synonyms

Neo-PAP
Neo-poly(A) polymerase
PAP-gamma
Polynucleotide adenylyltransferase gamma
SRP RNA 3'-adenylating enzyme

Gene Name

PAPOLG

Protein Type

Enzyme

Biological Properties

General Function

Involved in nucleotidyltransferase activity

Specific Function

Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA.

GO Classification

Biological Process
mRNA polyadenylation
transcription, DNA-dependent
Cellular Component
nucleus
Component
intracellular membrane-bounded organelle
nucleus
organelle
membrane-bounded organelle
Function
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
nucleotidyltransferase activity
adenylyltransferase activity
nucleic acid binding
polynucleotide adenylyltransferase activity
rna binding
Molecular Function
metal ion binding
ATP binding
RNA binding
polynucleotide adenylyltransferase activity
Process
macromolecule biosynthetic process
cellular macromolecule biosynthetic process
metabolic process
macromolecule metabolic process
cellular macromolecule metabolic process
rna processing
biosynthetic process
rna polyadenylation
transcription
rna 3'-end processing
rna metabolic process

Cellular Location

Nucleus

Pathways

Name	SMPDB/Pathwhiz	KEGG
mRNA surveillance pathway	Not Available

Gene Properties

Chromosome Location

Locus

2p16.1

SNPs

PAPOLG

Gene Sequence

>2211 bp
ATGAAAGAGATGTCTGCAAACACCGTGCTGGACAGCCAGCGTCAACAAAAGCATTATGGA
ATTACCTCCCCAATTAGTTTGGCATCTCCTAAAGAAATTGATCATATTTACACACAGAAA
TTAATTGACGCCATGAAACCATTTGGAGTGTTTGAAGATGAGGAAGAATTGAACCACAGG
CTGGTGGTTCTTGGTAAATTGAACAATTTAGTAAAAGAATGGATTTCTGATGTCAGCGAG
AGTAAGAACCTCCCACCTTCTGTTGTGGCTACTGTTGGTGGTAAAATTTTCACATTTGGA
TCCTATAGGCTTGGAGTACACACCAAAGGAGCTGACATTGATGCACTTTGTGTAGCTCCA
AGACATGTGGAAAGATCTGATTTTTTTCAGTCTTTTTTTGAAAAATTGAAACATCAAGAT
GGCATTAGAAACTTAAGAGCTGTAGAAGATGCCTTTGTACCTGTTATAAAATTTGAATTT
GATGGTATTGAAATTGATCTAGTCTTTGCAAGACTGGCAATACAAACCATATCAGATAAT
TTAGATCTAAGAGACGACTCTCGCCTGAGAAGCCTTGATATAAGGTGTATTCGCAGCTTA
AATGGTTGTAGAGTTACTGATGAAATTTTGCATTTAGTGCCAAATAAAGAAACTTTTAGA
CTCACCCTAAGAGCTGTCAAATTATGGGCAAAACGACGTGGTATTTATTCCAACATGCTA
GGATTCCTTGGTGGTGTCTCCTGGGCAATGCTAGTTGCAAGAACTTGCCAATTGTATCCA
AATGCAGCAGCATCTACTTTAGTTCATAAGTTCTTTTTAGTTTTTTCCAAGTGGGAATGG
CCAAATCCTGTGCTGCTGAAGCAACCAGAAGAAAGCAATTTGAATTTGCCTGTCTGGGAT
CCTCGGGTAAATCCATCAGATAGGTATCATCTCATGCCCATAATCACCCCTGCCTACCCA
CAACAGAATTCTACGTATAATGTGTCCACATCAACTCGAACAGTAATGGTAGAAGAATTT
AAACAAGGTCTTGCAGTCACAGATGAAATTCTTCAAGGAAAGTCAGATTGGTCCAAACTA
CTTGAGCCACCGAATTTCTTTCAAAAGTATAGACATTATATAGTATTGACTGCCAGCGCA
TCAACAGAAGAAAACCATCTAGAGTGGGTTGGATTAGTAGAATCTAAAATCCGTGTACTT
GTTGGAAACTTGGAACGGAATGAATTTATTACTCTTGCCCATGTGAATCCCCAGTCATTC
CCAGGGAATAAGGAACATCATAAAGACAACAATTACGTATCAATGTGGTTCCTTGGGATA
ATTTTTCGGAGAGTAGAAAATGCAGAAAGTGTCAACATAGACTTGACATATGATATACAG
TCATTTACTGATACAGTGTACAGACAGGCAAACAATATAAATATGCTAAAGGAGGGAATG
AAAATTGAAGCAACTCATGTAAAGAAAAAACAACTTCACCACTACCTTCCTGCAGAAATT
CTTCAAAAGAAGAAAAAGCAAAGTCTCTCTGATGTCAATCGAAGCTCGGGCGGACTTCAA
TCCAAAAGATTGTCTCTGGATAGCAGTTGTCTGGATAGCTCCAGAGACACTGATAATGGA
ACACCTTTTAATTCTCCAGCGTCCAAGTCTGATAGCCCTTCTGTAGGAGAAACAGAAAGG
AATAGTGCTGAGCCTGCTGCTGTAATTGTGGAGAAGCCACTGAGTGTACCACCAGCCCAA
GGACTTTCCATTCCAGTGATTGGCGCAAAAGTTGACTCTACAGTAAAAACTGTATCACCC
CCCACTGTGTGTACCATTCCTACCGTAGTAGGACGAAATGTCATTCCTAGAATCACAACA
CCTCACAACCCTGCCCAGGGACAACCGCATCTGAATGGAATGTCAAATATAACTAAGACT
GTTACACCTAAGAGATCCCATTCCCCATCCATAGATGGGACTCCTAAGAGGTTGAAAGAC
GTAGAAAAGTTTATTCGACTTGAATCAACATTTAAGGACCCCCGCACTGCTGAAGAAAGA
AAAAGAAAATCAGTGGATGCCATTGGAGGAGAATCTATGCCTATTCCAACTATTGATACA
TCACGCAAAAAGAGACTACCCAGTAAAGAACTACCAGATTCATCATCTCCAGTTCCAGCA
AACAACATCCGTGTCATCAAAAATTCCATTCGACTGACCCTTAATCGGTAA

Protein Properties

Number of Residues

736

Molecular Weight

82801.935

Theoretical pI

9.149

Pfam Domain Function

NTP_transf_2 (PF01909 )
PAP_central; (PF04928 )
PAP_RNA-bind (PF04926 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Poly(A) polymerase gamma
MKEMSANTVLDSQRQQKHYGITSPISLASPKEIDHIYTQKLIDAMKPFGVFEDEEELNHR
LVVLGKLNNLVKEWISDVSESKNLPPSVVATVGGKIFTFGSYRLGVHTKGADIDALCVAP
RHVERSDFFQSFFEKLKHQDGIRNLRAVEDAFVPVIKFEFDGIEIDLVFARLAIQTISDN
LDLRDDSRLRSLDIRCIRSLNGCRVTDEILHLVPNKETFRLTLRAVKLWAKRRGIYSNML
GFLGGVSWAMLVARTCQLYPNAAASTLVHKFFLVFSKWEWPNPVLLKQPEESNLNLPVWD
PRVNPSDRYHLMPIITPAYPQQNSTYNVSTSTRTVMVEEFKQGLAVTDEILQGKSDWSKL
LEPPNFFQKYRHYIVLTASASTEENHLEWVGLVESKIRVLVGNLERNEFITLAHVNPQSF
PGNKEHHKDNNYVSMWFLGIIFRRVENAESVNIDLTYDIQSFTDTVYRQANNINMLKEGM
KIEATHVKKKQLHHYLPAEILQKKKKQSLSDVNRSSGGLQSKRLSLDSSCLDSSRDTDNG
TPFNSPASKSDSPSVGETERNSAEPAAVIVEKPLSVPPAQGLSIPVIGAKVDSTVKTVSP
PTVCTIPTVVGRNVIPRITTPHNPAQGQPHLNGMSNITKTVTPKRSHSPSIDGTPKRLKD
VEKFIRLESTFKDPRTAEERKRKSVDAIGGESMPIPTIDTSRKKRLPSKELPDSSSPVPA
NNIRVIKNSIRLTLNR

External Links

GenBank ID Protein

15080911

UniProtKB/Swiss-Prot ID

Q9BWT3

UniProtKB/Swiss-Prot Entry Name

PAPOG_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AF312211

GeneCard ID