| Identification |
|---|
| HMDB Protein ID
| CDBP01009 |
| Secondary Accession Numbers
| Not Available |
| Name
| DNA nucleotidylexotransferase |
| Description
| Not Available |
| Synonyms
|
- Terminal addition enzyme
- Terminal deoxynucleotidyltransferase
- Terminal transferase
|
| Gene Name
| DNTT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in DNA binding |
| Specific Function
| Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.
|
| GO Classification
|
| Biological Process |
| DNA modification |
| Cellular Component |
| cytoplasm |
| nucleus |
| Component |
| cell part |
| intracellular |
| Function |
| binding |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| nucleotidyltransferase activity |
| dna polymerase activity |
| dna-directed dna polymerase activity |
| dna nucleotidylexotransferase activity |
| nucleic acid binding |
| dna binding |
| Molecular Function |
| metal ion binding |
| DNA-directed DNA polymerase activity |
| DNA nucleotidylexotransferase activity |
| DNA binding |
| Process |
| metabolic process |
| macromolecule metabolic process |
| cellular macromolecule metabolic process |
| dna metabolic process |
| dna replication |
|
| Cellular Location
|
- Nucleus
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Non-homologous end-joining | Not Available |  | | Hematopoietic cell lineage | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| 10q23-q24 |
| SNPs
| DNTT |
| Gene Sequence
|
>1530 bp
ATGGATCCACCACGAGCGTCCCACTTGAGCCCTCGGAAGAAGAGACCCCGGCAGACGGGT
GCCTTGATGGCCTCCTCTCCTCAAGACATCAAATTTCAAGATTTGGTCGTCTTCATTTTG
GAGAAGAAAATGGGAACCACCCGCAGAGCGTTCCTCATGGAGCTGGCCCGCAGGAAAGGG
TTCAGGGTTGAAAATGAGCTCAGTGATTCTGTCACCCACATTGTAGCAGAGAACAACTCG
GGTTCGGATGTTCTGGAGTGGCTTCAAGCACAGAAAGTACAAGTCAGCTCACAACCAGAG
CTCCTCGATGTCTCCTGGCTGATCGAATGCATAGGAGCAGGGAAACCGGTGGAAATGACA
GGAAAACACCAGCTTGTTGTGAGAAGAGACTATTCAGATAGCACCAACCCAGGCCCCCCG
AAGACTCCACCAATTGCTGTACAAAAGATCTCCCAGTATGCGTGTCAGAGAAGAACCACT
TTAAACAACTGTAACCAGATATTCACGGATGCCTTTGATATACTGGCTGAAAACTGTGAG
TTTAGAGAAAATGAAGACTCCTGTGTGACATTTATGAGAGCAGCTTCTGTATTGAAATCT
CTGCCATTCACAATCATCAGTATGAAGGACACAGAAGGAATTCCCTGCCTGGGGTCCAAG
GTGAAGGGTATCATAGAGGAGATTATTGAAGATGGAGAAAGTTCTGAAGTTAAAGCTGTG
TTAAATGATGAACGATATCAATCCTTCAAACTCTTTACTTCTGTATTTGGAGTGGGGCTG
AAGACTTCTGAGAAGTGGTTCAGGATGGGTTTCAGAACTCTGAGTAAAGTAAGGTCGGAC
AAAAGCCTGAAATTTACACGAATGCAGAAAGCAGGATTTCTGTATTATGAAGACCTTGTC
AGCTGTGTGACCAGGGCAGAAGCAGAGGCCGTCAGTGTGCTGGTTAAAGAGGCTGTCTGG
GCATTTCTTCCGGATGCTTTCGTCACCATGACAGGAGGGTTCCGGAGGGGTAAGAAGATG
GGGCATGATGTAGATTTTTTAATTACCAGCCCAGGATCAACAGAGGATGAAGAGCAACTT
TTACAGAAAGTGATGAACTTATGGGAAAAGAAGGGATTACTTTTATATTATGACCTTGTG
GAGTCAACATTTGAAAAGCTCAGGTTGCCTAGCAGGAAGGTTGATGCTTTGGATCATTTT
CAAAAGTGCTTTCTGATTTTCAAATTGCCTCGTCAAAGAGTGGACAGTGACCAGTCCAGC
TGGCAGGAAGGAAAGACCTGGAAGGCCATCCGTGTGGATTTAGTTCTGTGCCCCTACGAG
CGTCGTGCCTTTGCCCTGTTGGGATGGACTGGCTCCCGGCAGTTTGAGAGAGACCTCCGG
CGCTATGCCACACATGAGCGGAAGATGATTCTGGATAACCATGCTTTATATGACAAGACC
AAGAGGATATTCCTCAAAGCAGAAAGTGAAGAAGAAATTTTTGCGCATCTGGGATTGGAT
TATATTGAACCGTGGGAAAGAAATGCCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 509 |
| Molecular Weight
| 58407.595 |
| Theoretical pI
| 8.42 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>DNA nucleotidylexotransferase
MDPPRASHLSPRKKRPRQTGALMASSPQDIKFQDLVVFILEKKMGTTRRAFLMELARRKG
FRVENELSDSVTHIVAENNSGSDVLEWLQAQKVQVSSQPELLDVSWLIECIGAGKPVEMT
GKHQLVVRRDYSDSTNPGPPKTPPIAVQKISQYACQRRTTLNNCNQIFTDAFDILAENCE
FRENEDSCVTFMRAASVLKSLPFTIISMKDTEGIPCLGSKVKGIIEEIIEDGESSEVKAV
LNDERYQSFKLFTSVFGVGLKTSEKWFRMGFRTLSKVRSDKSLKFTRMQKAGFLYYEDLV
SCVTRAEAEAVSVLVKEAVWAFLPDAFVTMTGGFRRGKKMGHDVDFLITSPGSTEDEEQL
LQKVMNLWEKKGLLLYYDLVESTFEKLRLPSRKVDALDHFQKCFLIFKLPRQRVDSDQSS
WQEGKTWKAIRVDLVLCPYERRAFALLGWTGSRQFERDLRRYATHERKMILDNHALYDKT
KRIFLKAESEEEIFAHLGLDYIEPWERNA
|
| External Links |
|---|
| GenBank ID Protein
| 16923263 |
| UniProtKB/Swiss-Prot ID
| P04053 |
| UniProtKB/Swiss-Prot Entry Name
| TDT_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AB046378 |
| GeneCard ID
| DNTT |
| GenAtlas ID
| DNTT |
| HGNC ID
| HGNC:2983 |
| References |
|---|
| General References
| Not Available |