Showing Protein Acyl-coenzyme A thioesterase 8 (CDBP00986)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 16 compounds
Identification
HMDB Protein ID CDBP00986
Secondary Accession Numbers Not Available
Name Acyl-coenzyme A thioesterase 8
Description Not Available
Synonyms
  1. Acyl-CoA thioesterase 8
  2. Choloyl-coenzyme A thioesterase
  3. HIV-Nef-associated acyl-CoA thioesterase
  4. PTE-1
  5. PTE-2
  6. Peroxisomal acyl-coenzyme A thioester hydrolase 1
  7. Peroxisomal long-chain acyl-CoA thioesterase 1
  8. Thioesterase II
  9. hACTE-III
  10. hACTEIII
  11. hTE
Gene Name ACOT8
Protein Type Enzyme
Biological Properties
General Function Involved in acyl-CoA thioesterase activity
Specific Function Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May mediate Nef-induced down-regulation of CD4. Major thioesterase in peroxisomes. Competes with BAAT (Bile acid CoA: amino acid N-acyltransferase) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a preference for medium-length fatty acyl-CoAs (By similarity). May be involved in the metabolic regulation of peroxisome proliferation.
GO Classification
Biological Process
bile acid biosynthetic process
acyl-CoA metabolic process
dicarboxylic acid catabolic process
alpha-linolenic acid metabolic process
fatty acid beta-oxidation using acyl-CoA oxidase
peroxisome fission
virus-host interaction
Cellular Component
mitochondrion
peroxisomal matrix
Function
acyl-coa thioesterase activity
catalytic activity
hydrolase activity
thiolester hydrolase activity
coa hydrolase activity
hydrolase activity, acting on ester bonds
Molecular Function
carboxylesterase activity
palmitoyl-CoA hydrolase activity
choloyl-CoA hydrolase activity
medium-chain acyl-CoA hydrolase activity
Process
acyl-coa metabolic process
metabolic process
cellular metabolic process
cofactor metabolic process
coenzyme metabolic process
Cellular Location
  1. Peroxisome
Pathways
Gene Properties
Chromosome Location 20
Locus 20q13.12
SNPs ACOT8
Gene Sequence 
>960 bp
ATGTCGTCCCCGCAGGCCCCAGAAGATGGGCAGGGCTGTGGCGACCGCGGCGATCCCCCT
GGGGACCTCCGTAGCGTCTTGGTCACGACCGTGCTCAACCTCGAGCCGCTGGACGAGGAT
CTCTTCAGAGGAAGGCATTACTGGGTACCGGCCAAGAGGCTGTTTGGTGGTCAGATCGTG
GGCCAGGCCCTGGTGGCTGCAGCCAAGTCTGTGAGTGAAGACGTCCACGTGCACTCCCTG
CACTGCTACTTTGTTCGGGCAGGGGACCCGAAGCTGCCAGTACTGTACCAAGTGGAGCGG
ACACGAACAGGGTCGAGCTTCTCGGTGCGCTCTGTGAAGGCCGTGCAACATGGGAAGCCC
ATCTTCATCTGCCAGGCCTCCTTCCAGCAGGCCCAGCCCAGCCCCATGCAGCACCAGTTC
TCCATGCCCACTGTGCCACCACCAGAAGAGCTGCTTGACTGTGAGACCCTCATTGACCAG
TATTTAAGGGACCCTAACCTCCAAAAGAGGTACCCATTGGCGCTCAACCGAATTGCTGCT
CAGGAGGTCCCCATTGAGATCAAGCCAGTAAACCCATCCCCCCTGAGCCAGCTGCAGAGA
ATGGAGCCCAAACAGATGTTCTGGGTGCGAGCCCGGGGCTATATTGGCGAGGGCGACATG
AAGATGCACTGCTGCGTGGCCGCCTATATCTCCGACTATGCCTTCTTGGGCACTGCACTG
CTGCCTCACCAGTGGCAGCACAAGGTGCACTTCATGGTCTCACTGGACCATTCCATGTGG
TTCCACGCCCCCTTCCGAGCTGACCACTGGATGCTCTATGAATGCGAGAGCCCCTGGGCC
GGTGGCTCTCGGGGGCTGGTCCATGGGCGGCTGTGGCGTCAGGATGGAGTCCTAGCTGTG
ACCTGTGCCCAGGAGGGCGTGATCCGAGTGAAGCCCCAGGTCTCAGAGAGCAAGCTGTAG
Protein Properties
Number of Residues 319
Molecular Weight 35914.02
Theoretical pI 7.555
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Acyl-coenzyme A thioesterase 8
MSSPQAPEDGQGCGDRGDPPGDLRSVLVTTVLNLEPLDEDLFRGRHYWVPAKRLFGGQIV
GQALVAAAKSVSEDVHVHSLHCYFVRAGDPKLPVLYQVERTRTGSSFSVRSVKAVQHGKP
IFICQASFQQAQPSPMQHQFSMPTVPPPEELLDCETLIDQYLRDPNLQKRYPLALNRIAA
QEVPIEIKPVNPSPLSQLQRMEPKQMFWVRARGYIGEGDMKMHCCVAAYISDYAFLGTAL
LPHQWQHKVHFMVSLDHSMWFHAPFRADHWMLYECESPWAGGSRGLVHGRLWRQDGVLAV
TCAQEGVIRVKPQVSESKL
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID O14734
UniProtKB/Swiss-Prot Entry Name ACOT8_HUMAN
PDB IDs Not Available
GenBank Gene ID AF014404
GeneCard ID ACOT8
GenAtlas ID ACOT8
HGNC ID HGNC:15919
References
General References Not Available