| Identification |
|---|
| HMDB Protein ID
| CDBP00977 |
| Secondary Accession Numbers
| Not Available |
| Name
| 2,4-dienoyl-CoA reductase, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- 2,4-dienoyl-CoA reductase [NADPH]
- 4-enoyl-CoA reductase [NADPH]
|
| Gene Name
| DECR1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in oxidoreductase activity |
| Specific Function
| Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA.
|
| GO Classification
|
| Biological Process |
| protein homotetramerization |
| fatty acid beta-oxidation |
| Cellular Component |
| mitochondrial matrix |
| nucleus |
| Function |
| binding |
| catalytic activity |
| oxidoreductase activity |
| Molecular Function |
| 2,4-dienoyl-CoA reductase (NADPH) activity |
| oxidoreductase activity, acting on NADH or NADPH |
| NADPH binding |
| Process |
| metabolic process |
| oxidation reduction |
|
| Cellular Location
|
- Mitochondrion
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| 8q21.3 |
| SNPs
| DECR1 |
| Gene Sequence
|
>1008 bp
ATGAAGCTACCGGCCAGGGTTTTCTTTACTCTGGGGTCCCGGCTGCCCTGTGGCCTCGCT
CCTCGGAGGTTTTTCAGTTATGGGACAAAAATATTATATCAAAACACTGAAGCTTTGCAA
TCTAAATTCTTTTCACCTCTTCAAAAAGCGATGCTACCACCTAATAGTTTTCAAGGAAAA
GTGGCATTCATTACTGGGGGAGGTACTGGCCTTGGTAAAGGAATGACAACTCTTCTGTCC
AGCCTAGGTGCTCAGTGCGTGATAGCCAGCCGGAAGATGGATGTTTTGAAAGCTACCGCA
GAACAAATTTCTTCTCAAACTGGAAATAAGGTTCATGCAATTCAGTGTGATGTGAGGGAT
CCTGATATGGTTCAAAACACTGTGTCAGAACTGATCAAAGTTGCAGGACATCCTAATATT
GTGATAAACAATGCAGCAGGGAATTTTATTTCTCCTACTGAAAGACTTTCTCCTAATGCT
TGGAAAACCATAACTGACATAGTTCTAAATGGCACAGCCTTCGTGACACTAGAAATTGGA
AAACAACTAATTAAAGCACAGAAAGGAGCAGCATTTCTTTCTATTACTACTATCTATGCT
GAGACTGGTTCAGGTTTTGTAGTACCAAGTGCTTCTGCCAAAGCAGGTGTGGAAGCCATG
AGCAAGTCTCTTGCAGCTGAATGGGGTAAATATGGAATGCGATTCAATGTGATTCAACCA
GGGCCTATAAAAACCAAAGGTGCCTTTAGCCGTCTGGACCCAACTGGAACATTTGAGAAA
GAAATGATTGGCAGAATTCCCTGTGGTCGCCTGGGGACTGTAGAAGAACTCGCAAATCTT
GCTGCTTTCCTTTGTAGTGATTATGCTTCTTGGATTAATGGAGCAGTCATTAAATTTGAC
GGTGGAGAGGAAGTACTTATTTCAGGGGAATTCAACGACCTGAGAAAGGTCACCAAGGAG
CAGTGGGACACCATAGAAGAACTCATCAGGAAGACAAAAGGTTCCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 335 |
| Molecular Weight
| 36067.4 |
| Theoretical pI
| 9.274 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>2,4-dienoyl-CoA reductase, mitochondrial
MKLPARVFFTLGSRLPCGLAPRRFFSYGTKILYQNTEALQSKFFSPLQKAMLPPNSFQGK
VAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDVRD
PDMVQNTVSELIKVAGHPNIVINNAAGNFISPTERLSPNAWKTITDIVLNGTAFVTLEIG
KQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFNVIQP
GPIKTKGAFSRLDPTGTFEKEMIGRIPCGRLGTVEELANLAAFLCSDYASWINGAVIKFD
GGEEVLISGEFNDLRKVTKEQWDTIEELIRKTKGS
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q16698 |
| UniProtKB/Swiss-Prot Entry Name
| DECR_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| L26050 |
| GeneCard ID
| DECR1 |
| GenAtlas ID
| DECR1 |
| HGNC ID
| HGNC:2753 |
| References |
|---|
| General References
| Not Available |