| Identification |
|---|
| HMDB Protein ID
| CDBP00963 |
| Secondary Accession Numbers
| Not Available |
| Name
| Pantothenate kinase 1 |
| Description
| Not Available |
| Synonyms
|
- Pantothenic acid kinase 1
- hPanK
- hPanK1
|
| Gene Name
| PANK1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in pantothenate kinase activity |
| Specific Function
| Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity).
|
| GO Classification
|
| Biological Process |
| pantothenate metabolic process |
| coenzyme A biosynthetic process |
| coenzyme biosynthetic process |
| Cellular Component |
| cytosol |
| cell periphery |
| Function |
| binding |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| kinase activity |
| nucleoside binding |
| purine nucleoside binding |
| adenyl nucleotide binding |
| adenyl ribonucleotide binding |
| atp binding |
| pantothenate kinase activity |
| Molecular Function |
| ATP binding |
| pantothenate kinase activity |
| Process |
| metabolic process |
| coenzyme biosynthetic process |
| cellular metabolic process |
| coenzyme a biosynthetic process |
| cofactor metabolic process |
| coenzyme metabolic process |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | coenzyme A biosynthesis | Not Available | Not Available | | Pantothenate and CoA Biosynthesis |    |  | | Glycolysis |    |  | | Glycogenosis, Type VII. Tarui disease |    | Not Available | | Fanconi-bickel syndrome |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| 10q23.31 |
| SNPs
| PANK1 |
| Gene Sequence
|
>1797 bp
ATGTTGAAACTCGTCGGTGGCGGTGGCGGGCAGGACTGGGCATGCTCAGTGGCGGGGACC
AGTCTGGGAGGCGAGGAAGCCGCGTTTGAAGTCGCGCGGCCTGGGGATCAGGGGAAGGCG
GGCGGCGGGAGCCCCGGCTGGGGGTGCGCGGGGATCCCCGATTCCGCGCCCGGGGCTGGC
GTGCTCCAGGCCGGCGCCGTGGGGCCGGCGCGCGGGGGGCAGGGCGCAGAGGAGGTGGGG
GAGTCGGCAGGAGGAGGGGAGGAGCGCCGGGTTCGCCATCCCCAGGCGCCGGCTCTGCGG
CTGCTGAATCGGAAGCCGCAGGGAGGATCCGGGGAAATAAAGACGCCGGAGAATGACCTC
CAGCGAGGCCGCCTGAGCCGGGGCCCGCGCACAGCCCCGCCAGCCCCCGGCATGGGCGAC
CGCAGCGGGCAGCAGGAGCGCTCGGTCCCGCACTCTCCAGGGGCCCCCGTGGGCACCAGC
GCCGCCGCTGTGAACGGGCTGCTGCACAACGGCTTCCATCCGCCGCCAGTCCAGCCGCCG
CACGTCTGCAGCCGGGGTCCAGTGGGCGGCAGCGACGCGGCGCCCCAGCGCCTCCCGCTC
CTGCCGGAGCTGCAGCCGCAGCCACTGCTCCCTCAGCATGACTCCCCGGCCAAGAAATGC
CGGCTGCGGAGGAGGATGGACTCGGGGAGAAAGAACAGGCCGCCATTCCCATGGTTTGGC
ATGGACATCGGTGGAACGCTGGTTAAATTGGTGTATTTCGAGCCGAAGGATATTACAGCC
GAAGAGGAGCAAGAGGAAGTGGAGAACCTGAAGAGCATCCGGAAGTATTTGACTTCTAAT
ACTGCTTATGGGAAAACTGGGATCCGAGACGTCCACCTGGAACTGAAAAACCTGACCATG
TGTGGACGCAAAGGGAACCTGCACTTCATCCGCTTTCCCAGCTGTGCTATGCACAGGTTC
ATTCAGATGGGCAGCGAGAAGAACTTCTCTAGCCTTCACACCACCCTCTGTGCCACAGGA
GGCGGGGCTTTCAAATTCGAAGAGGACTTCAGAATGATTGCTGACCTGCAGCTGCATAAA
CTGGATGAACTGGACTGTCTGATTCAGGGCCTGCTTTATGTCGACTCTGTTGGCTTCAAC
GGCAAGCCAGAATGTTACTATTTTGAAAATCCCACAAATCCTGAATTGTGTCAAAAAAAG
CCGTACTGCCTTGATAACCCATACCCTATGTTGCTGGTTAACATGGGCTCAGGTGTCAGC
ATTCTAGCCGTGTACTCCAAGGACAACTATAAAAGAGTTACAGGGACCAGTCTTGGAGGT
GGAACATTCCTAGGCCTATGTTGCTTGCTGACTGGTTGTGAGACCTTTGAAGAAGCTCTG
GAAATGGCAGCTAAAGGCGACAGCACCAATGTTGATAAACTGGTGAAGGACATTTACGGA
GGAGACTATGAACGATTTGGCCTTCAAGGATCTGCTGTAGCATCAAGCTTTGGCAACATG
ATGAGTAAAGAAAAGCGAGATTCCATCAGCAAGGAAGACCTCGCCCGGGCCACATTGGTC
ACCATCACCAACAACATTGGCTCCATTGCTCGGATGTGCGCGTTGAATGAGAACATAGAC
AGAGTTGTGTTTGTTGGAAATTTTCTCAGAATCAATATGGTCTCCATGAAGCTGCTGGCA
TATGCCATGGATTTTTGGTCCAAAGGACAACTGAAAGCTCTGTTTTTGGAACATGAGGGT
TATTTTGGAGCCGTTGGGGCACTGTTGGAACTGTTCAAAATGACTGATGACAAGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 598 |
| Molecular Weight
| 35578.965 |
| Theoretical pI
| 7.636 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Pantothenate kinase 1
MLKLVGGGGGQDWACSVAGTSLGGEEAAFEVARPGDQGKAGGGSPGWGCAGIPDSAPGAG
VLQAGAVGPARGGQGAEEVGESAGGGEERRVRHPQAPALRLLNRKPQGGSGEIKTPENDL
QRGRLSRGPRTAPPAPGMGDRSGQQERSVPHSPGAPVGTSAAAVNGLLHNGFHPPPVQPP
HVCSRGPVGGSDAAPQRLPLLPELQPQPLLPQHDSPAKKCRLRRRMDSGRKNRPPFPWFG
MDIGGTLVKLVYFEPKDITAEEEQEEVENLKSIRKYLTSNTAYGKTGIRDVHLELKNLTM
CGRKGNLHFIRFPSCAMHRFIQMGSEKNFSSLHTTLCATGGGAFKFEEDFRMIADLQLHK
LDELDCLIQGLLYVDSVGFNGKPECYYFENPTNPELCQKKPYCLDNPYPMLLVNMGSGVS
ILAVYSKDNYKRVTGTSLGGGTFLGLCCLLTGCETFEEALEMAAKGDSTNVDKLVKDIYG
GDYERFGLQGSAVASSFGNMMSKEKRDSISKEDLARATLVTITNNIGSIARMCALNENID
RVVFVGNFLRINMVSMKLLAYAMDFWSKGQLKALFLEHEGYFGAVGALLELFKMTDDK
|
| External Links |
|---|
| GenBank ID Protein
| 23510400 |
| UniProtKB/Swiss-Prot ID
| Q8TE04 |
| UniProtKB/Swiss-Prot Entry Name
| PANK1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_148977.1 |
| GeneCard ID
| PANK1 |
| GenAtlas ID
| PANK1 |
| HGNC ID
| HGNC:8598 |
| References |
|---|
| General References
| Not Available |