| Identification |
|---|
| HMDB Protein ID
| CDBP00962 |
| Secondary Accession Numbers
| Not Available |
| Name
| Pantothenate kinase 2, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- Pantothenic acid kinase 2
- hPanK2
|
| Gene Name
| PANK2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in pantothenate kinase activity |
| Specific Function
| May be the master regulator of the CoA biosynthesis (By similarity).
|
| GO Classification
|
| Biological Process |
| pantothenate metabolic process |
| cell death |
| coenzyme A biosynthetic process |
| coenzyme biosynthetic process |
| Cellular Component |
| mitochondrial intermembrane space |
| Function |
| adenyl nucleotide binding |
| adenyl ribonucleotide binding |
| atp binding |
| pantothenate kinase activity |
| binding |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| kinase activity |
| nucleoside binding |
| purine nucleoside binding |
| Molecular Function |
| ATP binding |
| pantothenate kinase activity |
| Process |
| metabolic process |
| coenzyme biosynthetic process |
| cellular metabolic process |
| coenzyme a biosynthetic process |
| cofactor metabolic process |
| coenzyme metabolic process |
|
| Cellular Location
|
- Cytoplasm
- Mitochondrion
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | coenzyme A biosynthesis | Not Available | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 20 |
| Locus
| 20p13 |
| SNPs
| PANK2 |
| Gene Sequence
|
>1713 bp
ATGAGGAGGCTCGGGCCCTTCCACCCACGCGTCCATTGGGCGGCGCCGCCATCACTCTCT
TCTGGGCTACACCGCCTTCTCTTCCTCCGCGGAACCCGGATCCCCTCCTCCACCACCCTC
TCCCCGCCCCGTCACGATAGCCTCTCATTGGACGGAGGCACGGTCAATCCTCCTCGAGTT
AGGGAGCCGACTGGACGCGAGGCCTTTGGGCCGTCCCCAGCCTCGTCGGATTGGCTTCCT
GCGCGTTGGCGCAACGGAAGAGGCGGCCGGCCGAGGGCGCGCCTCTGCTCTGGCTGGACC
GCCGCGGAGGAGGCGAGAAGGAATCCGACGCTGGGGGGCTTGCTCGGGCGGCAGCGACTG
CTGCTGCGGATGGGAGCGGGCCGGCTCGGCGCGCCCATGGAGCGCCACGGCAGGGCTTCC
GCCACCTCCGTCTCGTCGGCTGGGGAGCAGGCGGCCGGGGACCCCGAAGGGCGGCGGCAG
GAGCCACTGCGGCGCCGGGCGAGCAGCGCGTCGGTGCCCGCGGTCGGGGCCTCGGCTGAG
GGCACGAGGCGGGATCGACTGGGCTCTTACAGCGGCCCCACCTCGGTCTCCCGCCAGCGC
GTCGAAAGCCTGAGGAAAAAGCGGCCGCTTTTTCCATGGTTTGGACTGGATATCGGTGGA
ACTCTGGTCAAGCTGGTATATTTTGAACCCAAAGACATCACTGCTGAAGAAGAAGAGGAA
GAGGTGGAAAGTCTTAAAAGTATTCGGAAGTACCTGACCTCCAATGTGGCTTATGGGTCT
ACAGGCATTCGGGACGTGCACCTCGAGCTGAAGGACCTGACTCTGTGTGGACGCAAAGGC
AATCTGCACTTTATACGCTTTCCCACTCATGACATGCCTGCTTTTATTCAAATGGGCAGA
GATAAAAACTTCTCGAGTCTCCACACTGTCTTTTGTGCCACTGGAGGTGGAGCGTACAAA
TTTGAGCAGGATTTTCTCACAATAGGTGATCTTCAGCTTTGCAAACTGGATGAACTAGAT
TGCTTGATCAAAGGAATTTTATACATTGACTCAGTCGGATTCAATGGACGGTCACAGTGC
TATTACTTTGAAAACCCTGCTGATTCTGAAAAGTGTCAGAAGTTACCATTTGATTTGAAA
AATCCGTATCCTCTGCTTCTGGTGAACATTGGCTCAGGGGTTAGCATCTTAGCAGTATAT
TCCAAAGATAATTACAAACGGGTCACAGGTACTAGTCTTGGAGGAGGAACTTTTTTTGGT
CTCTGCTGTCTTCTTACTGGCTGTACCACTTTTGAAGAAGCTCTTGAAATGGCATCTCGT
GGAGATAGCACCAAAGTGGATAAACTAGTACGAGATATTTATGGAGGGGACTATGAGAGG
TTTGGACTGCCAGGCTGGGCTGTGGCTTCAAGCTTTGGAAACATGATGAGCAAGGAGAAG
CGAGAGGCTGTCAGTAAAGAGGACCTGGCCAGAGCGACTTTGATCACCATCACCAACAAC
ATTGGCTCAATAGCAAGAATGTGTGCCCTTAATGAAAACATTAACCAGGTGGTATTTGTT
GGAAATTTCTTGAGAATTAATACGATCGCCATGCGGCTTTTGGCATATGCTTTGGATTAT
TGGTCCAAGGGGCAGTTGAAAGCACTTTTTTCGGAACACGAGGGTTATTTTGGAGCTGTT
GGAGCACTCCTTGAGCTGTTGAAGATCCCGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 570 |
| Molecular Weight
| 30753.12 |
| Theoretical pI
| 6.086 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Pantothenate kinase 2, mitochondrial
MRRLGPFHPRVHWAAPPSLSSGLHRLLFLRGTRIPSSTTLSPPRHDSLSLDGGTVNPPRV
REPTGREAFGPSPASSDWLPARWRNGRGGRPRARLCSGWTAAEEARRNPTLGGLLGRQRL
LLRMGGGRLGAPMERHGRASATSVSSAGEQAAGDPEGRRQEPLRRRASSASVPAVGASAE
GTRRDRLGSYSGPTSVSRQRVESLRKKRPLFPWFGLDIGGTLVKLVYFEPKDITAEEEEE
EVESLKSIRKYLTSNVAYGSTGIRDVHLELKDLTLCGRKGNLHFIRFPTHDMPAFIQMGR
DKNFSSLHTVFCATGGGAYKFEQDFLTIGDLQLCKLDELDCLIKGILYIDSVGFNGRSQC
YYFENPADSEKCQKLPFDLKNPYPLLLVNIGSGVSILAVYSKDNYKRVTGTSLGGGTFFG
LCCLLTGCTTFEEALEMASRGDSTKVDKLVRDIYGGDYERFGLPGWAVASSFGNMMSKEK
REAVSKEDLARATLITITNNIGSIARMCALNENINQVVFVGNFLRINTIAMRLLAYALDY
WSKGQLKALFSEHEGYFGAVGALLELLKIP
|
| External Links |
|---|
| GenBank ID Protein
| 23452046 |
| UniProtKB/Swiss-Prot ID
| Q9BZ23 |
| UniProtKB/Swiss-Prot Entry Name
| PANK2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF494409 |
| GeneCard ID
| PANK2 |
| GenAtlas ID
| PANK2 |
| HGNC ID
| HGNC:15894 |
| References |
|---|
| General References
| Not Available |