| Identification |
|---|
| HMDB Protein ID
| CDBP00957 |
| Secondary Accession Numbers
| Not Available |
| Name
| Alpha-(1,3)-fucosyltransferase |
| Description
| Not Available |
| Synonyms
|
- Fuc-TV
- FucT-V
- Fucosyltransferase 5
- Fucosyltransferase V
- Galactoside 3-L-fucosyltransferase
|
| Gene Name
| FUT5 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in fucosyltransferase activity |
| Specific Function
| May catalyze alpha-1,3 glycosidic linkages involved in the expression of VIM-2, Lewis X/SSEA-1 and sialyl Lewis X antigens.
|
| GO Classification
|
| Biological Process |
| L-fucose catabolic process |
| protein glycosylation |
| Cellular Component |
| Golgi apparatus |
| integral to membrane |
| Golgi cisterna membrane |
| Component |
| membrane |
| cell part |
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring hexosyl groups |
| transferase activity, transferring glycosyl groups |
| fucosyltransferase activity |
| Molecular Function |
| 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity |
| alpha-(1->3)-fucosyltransferase activity |
| Process |
| metabolic process |
| macromolecule metabolic process |
| macromolecule modification |
| protein modification process |
| protein amino acid glycosylation |
|
| Cellular Location
|
- Single-pass type II membrane protein
- Golgi apparatus
- Golgi stack membrane
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | protein glycosylation | Not Available | Not Available | | Glycosphingolipid biosynthesis - lacto and neolacto series | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| 19p13.3 |
| SNPs
| FUT5 |
| Gene Sequence
|
>1125 bp
ATGGATCCCCTGGGCCCAGCCAAGCCACAGTGGCTGTGGCGCCGCTGTCTGGCCGGGCTG
CTGTTTCAGCTGCTGGTGGCTGTGTGTTTCTTCTCCTACCTGCGTGTGTCCCGAGACGAT
GCCACTGGATCCCCTAGGCCAGGGCTTATGGCAGTGGAACCTGTCACCGGGGCTCCCAAT
GGGTCCCGCTGCCAGGACAGCATGGCGACCCCTGCCCACCCCACCCTACTGATCCTGCTG
TGGACGTGGCCTTTTAACACACCCGTGGCTCTGCCCCGCTGCTCAGAGATGGTGCCCGGC
GCGGCCGACTGCAACATCACTGCCGACTCCAGTGTGTACCCACAGGCAGACGCGGTCATC
GTGCACCACTGGGATATCATGTACAACCCCAGTGCCAACCTCCCGCCCCCCACCAGGCCG
CAGGGGCAGCGCTGGATCTGGTTCAGCATGGAGTCCCCCAGCAACTGCCGGCACCTGGAA
GCCCTGGACGGATACTTCAATCTCACCATGTCCTACCGCAGCGACTCCGACATCTTCACG
CCCTACGGCTGGCTGGAGCCGTGGTCCGGCCAGCCTGCCCACCCACCGCTCAACCTCTCG
GCCAAGACCGAGCTGGTGGCCTGGGCGGTGTCCAACTGGAAGCCGGACTCGGCCAGGGTG
CGCTACTACCAGAGCCTGCAGGCTCATCTCAAGGTGGACGTGTACGGACGCTCCCACAAG
CCCCTGCCCAAGGGGACCATGATGGAGACGCTGTCCCGGTACAAGTTCTATCTGGCCTTC
GAGAACTCCTTGCACCCCGACTACATCACCGAGAAGCTGTGGAGGAACGCCCTGGAGGCC
TGGGCCGTGCCCGTGGTGCTGGGCCCCAGCAGAAGCAACTACGAGAGGTTCCTGCCACCC
GACGCCTTCATCCACGTGGACGACTTCCAGAGCCCCAAGGACCTGGCCCGGTACCTGCAG
GAGCTGGACAAGGACCACGCCCGCTACCTGAGCTACTTTCACTGGCGGGAGACGCTGCGG
CCTCGCTCCTTCAGCTGGGCACTGGCTTTCTGCAAGGCCTGCTGGAAGCTGCAGCAGGAA
TCTAGGTACCAGACGGTGCGCAGCATAGCGGCTTGGTTCACCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 374 |
| Molecular Weight
| 42988.655 |
| Theoretical pI
| 8.113 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Alpha-(1,3)-fucosyltransferase
MDPLGPAKPQWLWRRCLAGLLFQLLVAVCFFSYLRVSRDDATGSPRPGLMAVEPVTGAPN
GSRCQDSMATPAHPTLLILLWTWPFNTPVALPRCSEMVPGAADCNITADSSVYPQADAVI
VHHWDIMYNPSANLPPPTRPQGQRWIWFSMESPSNCRHLEALDGYFNLTMSYRSDSDIFT
PYGWLEPWSGQPAHPPLNLSAKTELVAWAVSNWKPDSARVRYYQSLQAHLKVDVYGRSHK
PLPKGTMMETLSRYKFYLAFENSLHPDYITEKLWRNALEAWAVPVVLGPSRSNYERFLPP
DAFIHVDDFQSPKDLARYLQELDKDHARYLSYFRWRETLRPRSFSWALAFCKACWKLQQE
SRYQTVRSIAAWFT
|
| External Links |
|---|
| GenBank ID Protein
| 52485799 |
| UniProtKB/Swiss-Prot ID
| Q11128 |
| UniProtKB/Swiss-Prot Entry Name
| FUT5_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_002034.2 |
| GeneCard ID
| FUT5 |
| GenAtlas ID
| FUT5 |
| HGNC ID
| HGNC:4016 |
| References |
|---|
| General References
| Not Available |