| Identification |
|---|
| HMDB Protein ID
| CDBP00942 |
| Secondary Accession Numbers
| Not Available |
| Name
| Polypeptide N-acetylgalactosaminyltransferase 6 |
| Description
| Not Available |
| Synonyms
|
- GalNAc-T6
- Polypeptide GalNAc transferase 6
- Protein-UDP acetylgalactosaminyltransferase 6
- UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 6
- pp-GaNTase 6
|
| Gene Name
| GALNT6 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Cell wall/membrane/envelope biogenesis |
| Specific Function
| Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. May participate in synthesis of oncofetal fibronectin. Has activity toward Muc1a, Muc2, EA2 and fibronectin peptides.
|
| GO Classification
|
| Biological Process |
| O-glycan processing |
| post-translational protein modification |
| Cellular Component |
| perinuclear region of cytoplasm |
| integral to membrane |
| Golgi membrane |
| Molecular Function |
| polypeptide N-acetylgalactosaminyltransferase activity |
|
| Cellular Location
|
- Golgi apparatus membrane
- Single-pass type II membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | protein glycosylation | Not Available | Not Available | | Mucin type O-Glycan biosynthesis | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 12 |
| Locus
| 12q13 |
| SNPs
| GALNT6 |
| Gene Sequence
|
>1869 bp
ATGAGGCTCCTCCGCAGACGCCACATGCCCCTGCGCCTGGCCATGGTGGGCTGCGCCTTT
GTGCTCTTCCTCTTCCTCCTGCATAGGGATGTGAGCAGCAGAGAGGAGGCCACAGAGAAG
CCGTGGCTGAAGTCCCTGGTGAGCCGGAAGGATCACGTCCTGGACCTCATGCTGGAGGCC
ATGAACAACCTTAGAGATTCAATGCCCAAGCTCCAAATCAGGGCTCCAGAAGCCCAGCAG
ACTCTGTTCTCCATAAACCAGTCCTGCCTCCCTGGGTTCTATACCCCAGCTGAACTGAAG
CCCTTCTGGGAACGGCCACCACAGGACCCCAATGCCCCTGGGGCAGATGGAAAAGCATTT
CAGAAGAGCAAGTGGACCCCCCTGGAGACCCAGGAAAAGGAAGAAGGCTATAAGAAGCAC
TGTTTCAATGCCTTTGCCAGCGACCGGATCTCCCTGCAGAGGTCCCTGGGGCCAGACACC
CGACCACCTGAGTGTGTGGACCAGAAGTTCCGGCGCTGCCCCCCACTGGCCACCACCAGC
GTGATCATTGTGTTCCACAACGAAGCCTGGTCCACACTGCTGCGAACAGTGTACAGCGTC
CTACACACCACCCCTGCCATCTTGCTCAAGGAGATCATACTGGTGGATGATGCCAGCACA
GAGGAGCACCTAAAGGAGAAGCTGGAGCAGTACGTGAAGCAGCTGCAGGTGGTGAGGGTG
GTGCGGCAGGAGGAGCGGAAGGGGCTGATCACCGCCCGGCTGCTGGGGGCCAGCGTGGCA
CAGGCGGAGGTGCTCACGTTCCTGGATGCCCACTGTGAGTGCTTCCACGGCTGGCTGGAG
CCCCTCCTGGCTCGAATCGCTGAGGACAAGACAGTGGTGGTGAGCCCAGACATCGTCACC
ATCGACCTTAATACTTTTGAGTTCGCCAAGCCCGTCCAGAGGGGCAGAGTCCATAGCCGA
GGCAACTTTGACTGGAGCCTGACCTTCGGCTGGGAAACACTTCCTCCACATGAGAAGCAG
AGGCGCAAGGATGAAACCTACCCCATCAAATCCCCGACGTTTGCTGGTGGCCTCTTCTCC
ATCTCCAAGTCCTACTTTGAGCACATCGGTACCTATGATAATCAGATGGAGATCTGGGGA
GGGGAGAACGTGGAAATGTCCTTCCGGGTGTGGCAGTGTGGGGGCCAGCTGGAGATCATC
CCCTGCTCTGTCGTAGGCCATGTGTTCCGGACCAAGAGCCCCCACACCTTCCCCAAGGGC
ACTAGTGTCATTGCTCGCAATCAAGTGCGCCTGGCAGAGGTCTGGATGGACAGCTACAAG
AAGATTTTCTATAGGAGAAATCTGCAGGCAGCAAAGATGGCCCAAGAGAAATCCTTCGGT
GACATTTCGGAACGACTGCAGCTGAGGGAACAACTGCACTGTCACAACTTTTCCTGGTAC
CTGCACAATGTCTACCCAGAGATGTTTGTTCCTGACCTGACGCCCACCTTCTATGGTGCC
ATCAAGAACCTCGGCACCAACCAATGCCTGGATGTGGGTGAGAACAACCGCGGGGGGAAG
CCCCTCATCATGTACTCCTGCCACGGCCTTGGCGGCAACCAGTACTTTGAGTACACAACT
CAGAGGGACCTTCGCCACAACATCGCAAAGCAGCTGTGTCTACATGTCAGCAAGGGTGCT
CTGGGCCTTGGGAGCTGTCACTTCACTGGCAAGAATAGCCAGGTCCCCAAGGACGAGGAA
TGGGAATTGGCCCAGGATCAGCTCATCAGGAACTCAGGATCTGGTACCTGCCTGACATCC
CAGGACAAAAAGCCAGCCATGGCCCCCTGCAATCCCAGTGACCCCCATCAGTTGTGGCTC
TTTGTCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 622 |
| Molecular Weight
| 71158.055 |
| Theoretical pI
| 8.171 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Polypeptide N-acetylgalactosaminyltransferase 6
MRLLRRRHMPLRLAMVGCAFVLFLFLLHRDVSSREEATEKPWLKSLVSRKDHVLDLMLEA
MNNLRDSMPKLQIRAPEAQQTLFSINQSCLPGFYTPAELKPFWERPPQDPNAPGADGKAF
QKSKWTPLETQEKEEGYKKHCFNAFASDRISLQRSLGPDTRPPECVDQKFRRCPPLATTS
VIIVFHNEAWSTLLRTVYSVLHTTPAILLKEIILVDDASTEEHLKEKLEQYVKQLQVVRV
VRQEERKGLITARLLGASVAQAEVLTFLDAHCECFHGWLEPLLARIAEDKTVVVSPDIVT
IDLNTFEFAKPVQRGRVHSRGNFDWSLTFGWETLPPHEKQRRKDETYPIKSPTFAGGLFS
ISKSYFEHIGTYDNQMEIWGGENVEMSFRVWQCGGQLEIIPCSVVGHVFRTKSPHTFPKG
TSVIARNQVRLAEVWMDSYKKIFYRRNLQAAKMAQEKSFGDISERLQLREQLHCHNFSWY
LHNVYPEMFVPDLTPTFYGAIKNLGTNQCLDVGENNRGGKPLIMYSCHGLGGNQYFEYTT
QRDLRHNIAKQLCLHVSKGALGLGSCHFTGKNSQVPKDEEWELAQDQLIRNSGSGTCLTS
QDKKPAMAPCNPSDPHQLWLFV
|
| External Links |
|---|
| GenBank ID Protein
| 115298684 |
| UniProtKB/Swiss-Prot ID
| Q8NCL4 |
| UniProtKB/Swiss-Prot Entry Name
| GALT6_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_007210.3 |
| GeneCard ID
| GALNT6 |
| GenAtlas ID
| GALNT6 |
| HGNC ID
| HGNC:4128 |
| References |
|---|
| General References
| Not Available |