| Identification |
|---|
| HMDB Protein ID
| CDBP00941 |
| Secondary Accession Numbers
| Not Available |
| Name
| N-acetylgalactosaminyltransferase 7 |
| Description
| Not Available |
| Synonyms
|
- GalNAc-T7
- Polypeptide GalNAc transferase 7
- Protein-UDP acetylgalactosaminyltransferase 7
- UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 7
- pp-GaNTase 7
|
| Gene Name
| GALNT7 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in polypeptide N-acetylgalactosaminyltransfera |
| Specific Function
| Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide. In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Golgi apparatus membrane
- Single-pass type II membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:4 |
| Locus
| 4q31.1 |
| SNPs
| GALNT7 |
| Gene Sequence
|
>1974 bp
ATGAGGCTGAAGATTGGGTTCATCTTACGCAGTTTGCTGGTGGTGGGAAGCTTCCTGGGG
CTAGTGGTCCTCTGGTCTTCCCTGACCCCGCGGCCGGACGACCCAAGCCCGCTGAGCAGG
ATGAGGGAAGACAGAGATGTCAATGACCCCATGCCCAACCGAGGCGGCAATGGACTAGCT
CCTGGGGAGGACAGATTCAAACCTGTGGTACCATGGCCTCATGTTGAAGGAGTAGAAGTG
GACTTAGAGTCTATTAGAAGAATAAACAAGGCCAAAAATGAACAAGAGCACCATGCTGGA
GGAGATTCCCAGAAAGATATCATGCAGAGGCAGTATCTCACATTTAAGCCTCAGACATTC
ACCTACCATGATCCTGTGCTTCGCCCAGGGATCCTCGGTAACTTTGAACCCAAAGAACCT
GAGCCTCCTGGAGTGGTTGGTGGCCCTGGAGAGAAAGCCAAGCCATTGGTTTTGGGACCA
GAATTCAAACAAGCAATTCAAGCCAGCATTAAAGAGTTTGGATTTAACATGGTGGCAAGT
GACATGATCTCACTGGACCGCAACGTCAATGACTTACGCCAAGAAGAATGCAAGTATTGG
CATTATGATGAAAACTTGCTCACTTCGAGCGTTGTCATTGTCTTCCATAATGAAGGATGG
TCAACCCTCATGAGAACAGTCCACAGTGTAATTAAAAGGACTCCAAGGAAATATTTAGCA
GAAATTGTGTTAATTGACGATTTCAGTAATAAAGAACACTTAAAAGAAAAACTGGATGAA
TATATTAAGCTGTGGAATGGCCTAGTGAAGGTATTTCGAAATGAAAGAAGGGAAGGTTTA
ATTCAAGCACGAAGTATTGGTGCTCAGAAGGCTAAACTTGGACAGGTTTTGATATACCTT
GATGCCCACTGTGAAGTGGCAGTTAACTGGTATGCACCACTTGTAGCTCCCATATCTAAG
GACAGAACCATTTGCACTGTGCCGCTTATAGATGTCATAAATGGCAACACATATGAAATT
ATACCCCAAGGGGGTGGTGATGAAGATGGGTATGCCCGAGGAGCATGGGATTGGAGTATG
CTCTGGAAACGGGTGCCTCTGACCCCTCAAGAGAAGAGACTGAGAAAAACAAAAACTGAA
CCGTATCGGTCCCCAGCCATGGCTGGGGGATTATGTGCCATTGAACGAGAGTTCTTCTTT
GAATTGGGTCTCTATGATCCAAGTCTCCAGATTTGGGGTGGTGAAAACTTTGAGATCTCA
TACAAGATATGGCAGTGTGGTGGCAAATTATTATTTGTTCCTTGTTCTCGTGTTGGACAT
ATCTACCGTCTTGAGGGCTGGCAAGGAAATCCTCCGCCCATTTATGTTGGGTCTTCTCCA
ACTCTGAAGAATTATGTTAGAGTTGTGGAGGTTTGGTGGGATGAATATAAAGACTACTTC
TATGCTAGTCGTCCTGAATCGCAGGCATTACCATATGGGGATATATCGGAGCTGAAAAAA
TTTCGAGAAGATCACAACTGCCAAAGTTTTAAGTGGTTCATGGAAGAAATAGCTTATGAT
ATCACCTCACACTACCCTTTGCCACCCAAAAATGTTGACTGGGGAGAAATCAGAGGCTTC
GAAACTGCTTACTGCATTGATAGCATGGGAAAAACAAATGGAGGCTTTGTTGAACTAGGA
CCCTGCCACAGGATGGGAGGGAATCAGCTTTTCAGAATCAATGAAGCAAATCAACTCATG
CAGTATGACCAGTGTTTGACAAAGGGAGCTGATGGATCAAAAGTTATGATTACACACTGT
AATCTAAATGAATTTAAGGAATGGCAGTACTTCAAGAACCTGCACAGATTTACTCATATT
CCTTCAGGAAAGTGTTTAGATCGCTCAGAGGTCCTGCATCAAGTATTCATCTCCAATTGT
GACTCCAGTAAAACGACTCAAAAATGGGAAATGAATAACATCCATAGTGTTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 657 |
| Molecular Weight
| 75388.6 |
| Theoretical pI
| 7.12 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>N-acetylgalactosaminyltransferase 7
MRLKIGFILRSLLVVGSFLGLVVLWSSLTPRPDDPSPLSRMREDRDVNDPMPNRGGNGLA
PGEDRFKPVVPWPHVEGVEVDLESIRRINKAKNEQEHHAGGDSQKDIMQRQYLTFKPQTF
TYHDPVLRPGILGNFEPKEPEPPGVVGGPGEKAKPLVLGPEFKQAIQASIKEFGFNMVAS
DMISLDRSVNDLRQEECKYWHYDENLLTSSVVIVFHNEGWSTLMRTVHSVIKRTPRKYLA
EIVLIDDFSNKEHLKEKLDEYIKLWNGLVKVFRNERREGLIQARSIGAQKAKLGQVLIYL
DAHCEVAVNWYAPLVAPISKDRTICTVPLIDVINGNTYEIIPQGGGDEDGYARGAWDWSM
LWKRVPLTPQEKRLRKTKTEPYRSPAMAGGLFAIEREFFFELGLYDPGLQIWGGENFEIS
YKIWQCGGKLLFVPCSRVGHIYRLEGWQGNPPPIYVGSSPTLKNYVRVVEVWWDEYKDYF
YASRPESQALPYGDISELKKFREDHNCKSFKWFMEEIAYDITSHYPLPPKNVDWGEIRGF
ETAYCIDSMGKTNGGFVELGPCHRMGGNQLFRINEANQLMQYDQCLTKGADGSKVMITHC
NLNEFKEWQYFKNLHRFTHIPSGKCLDRSEVLHQVFISNCDSSKTTQKWEMNNIHSV
|
| External Links |
|---|
| GenBank ID Protein
| 6318186 |
| UniProtKB/Swiss-Prot ID
| Q86SF2 |
| UniProtKB/Swiss-Prot Entry Name
| GALT7_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AJ002744 |
| GeneCard ID
| GALNT7 |
| GenAtlas ID
| GALNT7 |
| HGNC ID
| HGNC:4129 |
| References |
|---|
| General References
| Not Available |