| Identification |
|---|
| HMDB Protein ID
| CDBP00934 |
| Secondary Accession Numbers
| Not Available |
| Name
| Probable polypeptide N-acetylgalactosaminyltransferase 8 |
| Description
| Not Available |
| Synonyms
|
- GalNAc-T8
- Polypeptide GalNAc transferase 8
- Protein-UDP acetylgalactosaminyltransferase 8
- UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 8
- pp-GaNTase 8
|
| Gene Name
| GALNT8 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Cell wall/membrane/envelope biogenesis |
| Specific Function
| Probably catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor (By similarity).
|
| GO Classification
|
| Biological Process |
| O-glycan processing |
| post-translational protein modification |
| Cellular Component |
| integral to membrane |
| Golgi membrane |
| Molecular Function |
| polypeptide N-acetylgalactosaminyltransferase activity |
|
| Cellular Location
|
- Golgi apparatus membrane
- Single-pass type II membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | protein glycosylation | Not Available | Not Available | | Mucin type O-Glycan biosynthesis | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 12 |
| Locus
| 12p13.3 |
| SNPs
| GALNT8 |
| Gene Sequence
|
>1914 bp
ATGATGTTTTGGAGGAAACTCCCCAAAGCCCTCTTCATTGGGCTGACTCTGGCCATTGCT
GTCAATCTCCTTCTGGTATTTTCTAGCAAGGGGACTTTACAAAACCTGTTTACGGGTGGT
CTCCACAGGGAGCTTCCTTTACATCTGAATAAACGCTACGGGGCAGTGATAAAGAGACTC
TCCCACTTGGAGGTGGAATTGCAGGATCTGAAAGAAAGTATGAAATTAGCTCTGAGGCAA
CAAGAAAATGTGAACAGCACACTGAAGAGGGCGAAAGATGAAGTACGCCCTCTTCTAAAG
GCAATGGAAACCAAGGTGAATGAGACAAAGAAGCACAAAACCCAAATGAAACTCTTCCCA
CACTCACAGCTTTTCAGGCAATGGGGCGAGGATCTTTCTGAGGCCCAGCAGAAGGCGGCC
CAGGACCTCTTCCGGAAGTTTGGTTACAACGCGTACCTCAGCAACCAGCTGCCTCTCAAT
CGCACCATCCCCGACACGCGAGACTACAGATGTCTTCGGAAGACATATCCTTCCCAACTC
CCATCCCTCAGTGTCATTCTCATATTCGTGAATGAAGCTCTGTCCATTATACAACGGGCC
ATCACCAGTATCATCAACCGGACGCCCTCTCGATTGTTGAAGGAAATCATCTTGGTGGAT
GATTTCAGCTCAAATGGAGAACTAAAGGTACACTTGGATGAGAAGATTAAGCTTTACAAC
CAGAAGTATCCAGGACTACTGAAAATAATACGGCATCCTGAAAGGAAAGGTCTTGCTCAA
GCCCGCAACACTGGCTGGGAAGCTGCCACAGCAGACGTGGTCGCCATCTTGGATGCTCAC
ATTGAAGTCAATGTTGGGTGGGCAGAGCCAATCTTGGCTCGGATTCAGGAGGACCGCACT
GTGATTGTGTCTCCTGTGTTTGACAACATTCGTTTTGACACCTTCAAACTGGATAAGTAT
GAACTGGCAGTTGATGGGTTTAACTGGGAACTCTGGTGCCGCTACGATGCACTGCCACAA
GCCTGGATTGATCTGCATGATGTCACTGCCCCAGTGAAGAGTCCTTCAATCATGGGCATC
CTGGCTGCTAACAGGCACTTCCTGGGAGAGATCGGGTCTCTGGATGGTGGAATGCTCATC
TATGGAGGAGAGAACGTGGAGCTTAGCCTGAGGGTGTGGCAGTGTGGAGGGAAGGTCGAG
ATTTTGCCCTGTTCCCGGATTGCCCACCTAGAGAGACACCACAAGCCCTACGCCTTGGAT
CTCACCGCTGCCTTGAAGCGCAATGCTCTGCGAGTGGCCGAAATCTGGATGGATGAGCAC
AAACACATGGTCTACTTGGCCTGGAACATACCTCTCCAGAACTCTGGAATAGATTTTGGA
GACGTTTCTTCCAGAATGGCACTCCGGGAAAAACTGAAATGTAAAACTTTTGACTGGTAC
CTGAAAAATGTTTATCCACTCTTGAAGCCACTCCACACCATCGTGGGCTATGGAAGAATG
AAAAACCTATTGGATGAAAATGTCTGCTTGGATCAGGGACCCGTTCCAGGCAACACCCCC
ATCATGTATTACTGCCATGAATTCAGCTCACAGAATGTCTACTATCACCTAACTGGGGAG
CTCTATGTGGGACAACTGATTGCAGAGGCCAGTGCTAGTGATCGCTGCCTGACAGACCCT
GGCAAGGCGGAGAAGCCCACCTTAGAACCATGCTCCAAGGCAGCTAAGAATAGACTGCAT
ATATATTGGGATTTTAAACCGGGAGGAGCTGTCATAAACAGAGATACCAAGCGGTGTCTG
GAGATGAAGAAGGATCTTTTGGGTAGCCACGTGCTTGTGCTCCAGACCTGTAGCACGCAA
GTGTGGGAAATCCAGCACACTGTCAGAGACTGGGGTCAGACCAACAGCCAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 637 |
| Molecular Weight
| 72850.77 |
| Theoretical pI
| 8.86 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Probable polypeptide N-acetylgalactosaminyltransferase 8
MMFWRKLPKALFIGLTLAIAVNLLLVFSSKGTLQNLFTGGLHRELPLHLNKRYGAVIKRL
SHLEVELQDLKESMKLALRQQENVNSTLKRAKDEVRPLLKAMETKVNETKKHKTQMKLFP
HSQLFRQWGEDLSEAQQKAAQDLFRKFGYNAYLSNQLPLNRTIPDTRDYRCLRKTYPSQL
PSLSVILIFVNEALSIIQRAITSIINRTPSRLLKEIILVDDFSSNGELKVHLDEKIKLYN
QKYPGLLKIIRHPERKGLAQARNTGWEAATADVVAILDAHIEVNVGWAEPILARIQEDRT
VIVSPVFDNIRFDTFKLDKYELAVDGFNWELWCRYDALPQAWIDLHDVTAPVKSPSIMGI
LAANRHFLGEIGSLDGGMLIYGGENVELSLRVWQCGGKVEILPCSRIAHLERHHKPYALD
LTAALKRNALRVAEIWMDEHKHMVYLAWNIPLQNSGIDFGDVSSRMALREKLKCKTFDWY
LKNVYPLLKPLHTIVGYGRMKNLLDENVCLDQGPVPGNTPIMYYCHEFSSQNVYYHLTGE
LYVGQLIAEASASDRCLTDPGKAEKPTLEPCSKAAKNRLHIYWDFKPGGAVINRDTKRCL
EMKKDLLGSHVLVLQTCSTQVWEIQHTVRDWGQTNSQ
|
| External Links |
|---|
| GenBank ID Protein
| 7657926 |
| UniProtKB/Swiss-Prot ID
| Q9NY28 |
| UniProtKB/Swiss-Prot Entry Name
| GALT8_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AJ271385 |
| GeneCard ID
| GALNT8 |
| GenAtlas ID
| GALNT8 |
| HGNC ID
| HGNC:4130 |
| References |
|---|
| General References
| Not Available |