Cannabis Compound Database: Showing Protein Arachidonate 15-lipoxygenase B (CDBP00911)

Identification Biological properties Gene properties Protein properties External links References XML Show 2 compounds

Identification

HMDB Protein ID

CDBP00911

Secondary Accession Numbers

Not Available

Name

Arachidonate 15-lipoxygenase B

Description

Not Available

Synonyms

15-LOX-2
15-LOX-B
15-lipoxygenase 2
Arachidonate 15-lipoxygenase type II

Gene Name

ALOX15B

Protein Type

Enzyme

Biological Properties

General Function

Involved in metal ion binding

Specific Function

Converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while linoleic acid is less well metabolized.

GO Classification

Biological Process
leukotriene biosynthetic process
negative regulation of cell proliferation
negative regulation of cell cycle
fatty acid metabolic process
negative regulation of growth
prostate gland development
induction of apoptosis
regulation of epithelial cell differentiation
negative regulation of cell migration
Cellular Component
intracellular
cytoplasm
Function
ion binding
cation binding
metal ion binding
binding
catalytic activity
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
transition metal ion binding
iron ion binding
lipoxygenase activity
oxidoreductase activity
Molecular Function
arachidonate 15-lipoxygenase activity
iron ion binding
lipoxygenase activity
Process
metabolic process
cellular metabolic process
organic acid metabolic process
oxoacid metabolic process
carboxylic acid metabolic process
monocarboxylic acid metabolic process
fatty acid metabolic process
oxidation reduction
unsaturated fatty acid metabolic process
icosanoid metabolic process
leukotriene metabolic process

Cellular Location

Cytoplasm

Pathways

Name	SMPDB/Pathwhiz	KEGG
leukotriene D4 biosynthesis	Not Available	Not Available
Serotonergic synapse	Not Available
Arachidonic Acid Metabolism
Leukotriene C4 Synthesis Deficiency		Not Available
Piroxicam Action Pathway		Not Available

Gene Properties

Chromosome Location

Locus

17p13.1

SNPs

ALOX15B

Gene Sequence

>2031 bp
ATGGCCGAGTTCAGGGTCAGGGTGTCCACCGGAGAAGCCTTCGGGGCTGGCACATGGGAC
AAAGTGTCTGTCAGCATCGTGGGGACCCGGGGAGAGAGCCCCCCACTGCCCCTGGACAAT
CTCGGCAAGGAGTTCACTGCGGGCGCTGAGGAGGACTTCCAGGTGACGCTCCCGGAGGAC
GTAGGCCGAGTGCTGCTGCTGCGCGTGCACAAGGCGCCCCCAGTGCTGCCCCTGCTGGGG
CCCCTGGCCCCGGATGCCTGGTTCTGCCGCTGGTTCCAGCTGACACCGCCGCGGGGCGGC
CACCTCCTCTTCCCCTGCTACCAGTGGCTGGAGGGGGCGGGGACCCTGGTGCTGCAGGAG
GGTACAGCCAAGGTGTCCTGGGCAGACCACCACCCTGTGCTCCAGCAACAGCGCCAGGAG
GAGCTTCAGGCCCGGCAGGAGATGTACCAGTGGAAGGCTTACAACCCAGGTTGGCCTCAC
TGCCTGGATGAAAAGACAGTGGAAGACTTGGAGCTCAATATCAAATACTCCACAGCCAAG
AATGCCAACTTTTATCTACAGGCTGGCTCTGCTTTTGCAGAGATGAAAATCAAGGGGTTG
CTGGACCGCAAGGGGCTCTGGAGGAGTCTGAATGAGATGAAAAGGATCTTCAACTTCCGG
AGGACCCCAGCAGCTGAGCACGCATTTGAGCACTGGCAGGAGGATGCCTTCTTCGCCTCC
CAGTTCCTGAATGGTCTCAACCCTGTCCTGATCCGCCGCTGTCACTACCTCCCAAAGAAC
TTCCCCGTCACTGATGCCATGGTGGCCTCAGTGTTGGGTCCTGGGACCAGCTTGCAGGCT
GAGCTAGAGAAGGGCTCCCTGTTCTTGGTGGATCACGGCATCCTCTCTGGCATCCAGACC
AATGTCATTAATGGGAAGCCTCAGTTCTCTGCGGCCCCAATGACCCTGCTATACCAGAGC
CCAGGCTGCGGGCCGCTGCTGCCTCTCGCCATCCAGCTCAGCCAGACCCCCGGCCCAAAC
AGCCCCATCTTCCTGCCCACTGATGACAAGTGGGACTGGTTGCTGGCCAAGACCTGGGTG
CGCAATGCCGAGTTCTCCTTCCATGAGGCCCTCACGCACCTGCTGCACTCACATCTGCTG
CCTGAGGTCTTCACCCTGGCTACCCTGCGTCAGCTGCCCCACTGCCACCCTCTCTTCAAG
CTGCTGATCCCGCACACCCGATACACCCTGCACATCAACACACTCGCCCGGGAGCTGCTT
ATCGTGCCAGGGCAGGTGGTGGACAGGTCCACAGGCATCGGCATTGAAGGCTTCTCTGAG
TTGATACAGAGGAACATGAAGCAGCTGAACTATTCTCTCCTGTGTCTGCCTGAGGATATC
CGGACCCGAGGAGTTGAAGACATCCCAGGCTACTACTACCGTGATGATGGGATGCAGATC
TGGGGTGCAGTGGAACACTTTGTCTCTGAAATCATCGGTATCTACTACCCAAGTGATGAG
TCTGTCCAAGATGACAGAGAGCTCCAGGCCTGGGTCAGAGAGATCTTCTCCAAGGGCTTC
CTAAACCAGGAGAGCTCAGGTATACCCTCCTCACTGGAGACCCGGGAAGCCCTGGTGCAG
TATGTCACCATGGTGATATTCACCTGCTCCGCCAAGCATGCGGCTGTCAGTGCAGGGCAG
TTTGACTCCTGTGCTTGGATGCCCAACCTGCCACCCAGCATGCAGCTGCCACCACCCACC
TCCAAAGGCCTGGCAACATGCGAGGGCTTCATAGCCACCCTCCCACCTGTCAATGCCACA
TGTGATGTCATCCTTGCTCTCTGGTTGCTGAGCAAGGAGCCTGGAGACCAAAGGCCCCTG
GGCACCTATCCGGATGAGCACTTCACAGAGGAGGCCCCTCGGCGGAGCATCGCCACCTTC
CAGAGCCGCCTGGCCCAGATCTCGAGGGGCATCCAGGAGCGGAACCGGGGCCTGGTGCTG
CCCTACACCTACCTAGACCCTCCCCTCATCGAGAACAGCGTCTCCATCTAA

Protein Properties

Number of Residues

676

Molecular Weight

72522.25

Theoretical pI

5.876

Pfam Domain Function

PLAT (PF01477 )
Lipoxygenase (PF00305 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Arachidonate 15-lipoxygenase B
MAEFRVRVSTGEAFGAGTWDKVSVSIVGTRGESPPLPLDNLGKEFTAGAEEDFQVTLPED
VGRVLLLRVHKAPPVLPLLGPLAPDAWFCRWFQLTPPRGGHLLFPCYQWLEGAGTLVLQE
GTAKVSWADHHPVLQQQRQEELQARQEMYQWKAYNPGWPHCLDEKTVEDLELNIKYSTAK
NANFYLQAGSAFAEMKIKGLLDRKGLWRSLNEMKRIFNFRRTPAAEHAFEHWQEDAFFAS
QFLNGLNPVLIRRCHYLPKNFPVTDAMVASVLGPGTSLQAELEKGSLFLVDHGILSGIQT
NVINGKPQFSAAPMTLLYQSPGCGPLLPLAIQLSQTPGPNSPIFLPTDDKWDWLLAKTWV
RNAEFSFHEALTHLLHSHLLPEVFTLATLRQLPHCHPLFKLLIPHTRYTLHINTLARELL
IVPGQVVDRSTGIGIEGFSELIQRNMKQLNYSLLCLPEDIRTRGVEDIPGYYYRDDGMQI
WGAVERFVSEIIGIYYPSDESVQDDRELQAWVREIFSKGFLNQESSGIPSSLETREALVQ
YVTMVIFTCSAKHAAVSAGQFDSCAWMPNLPPSMQLPPPTSKGLATCEGFIATLPPVNAT
CDVILALWLLSKEPGDQRPLGTYPDEHFTEEAPRRSIATFQSRLAQISRGIQERNRGLVL
PYTYLDPPLIENSVSI

External Links

GenBank ID Protein

18643345

UniProtKB/Swiss-Prot ID

O15296

UniProtKB/Swiss-Prot Entry Name

LX15B_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AF468051

GeneCard ID