Cannabis Compound Database: Showing Protein 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (CDBP00892)

Identification Biological properties Gene properties Protein properties External links References XML Show 7 compounds

Identification

HMDB Protein ID

CDBP00892

Secondary Accession Numbers

Not Available

Name

3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

Description

Not Available

Synonyms

Cholestenol Delta-isomerase
D8-D7 sterol isomerase
Delta(8)-Delta(7) sterol isomerase
Emopamil-binding protein

Gene Name

EBP

Protein Type

Enzyme

Biological Properties

General Function

Involved in cholestenol delta-isomerase activity

Specific Function

Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers.

GO Classification

Biological Process
cholesterol biosynthetic process
hemopoiesis
skeletal system development
Cellular Component
endoplasmic reticulum membrane
integral to plasma membrane
Component
cell part
membrane part
endoplasmic reticulum
intrinsic to membrane
organelle
membrane-bounded organelle
intracellular membrane-bounded organelle
integral to membrane
Function
catalytic activity
intramolecular oxidoreductase activity, transposing c=c bonds
cholestenol delta-isomerase activity
isomerase activity
intramolecular oxidoreductase activity
Molecular Function
transmembrane signaling receptor activity
C-8 sterol isomerase activity
cholestenol delta-isomerase activity
drug transmembrane transporter activity
steroid delta-isomerase activity
Process
sterol metabolic process
metabolic process
small molecule metabolic process
alcohol metabolic process

Cellular Location

Endoplasmic reticulum membrane
Multi-pass membrane protein

Pathways

Name	SMPDB/Pathwhiz	KEGG
cholesterol biosynthesis	Not Available	Not Available
Steroid Biosynthesis
Smith-Lemli-Opitz Syndrome (SLOS)		Not Available
CHILD Syndrome		Not Available
Desmosterolosis		Not Available

Gene Properties

Chromosome Location

Locus

Xp11.23-p11.22

SNPs

EBP

Gene Sequence

>693 bp
ATGACTACCAACGCGGGCCCCTTGCACCCATACTGGCCTCAGCACCTAAGACTGGACAAC
TTTGTACCTAATGACCGCCCCACCTGGCATATACTGGCTGGCCTCTTCTCTGTCACAGGG
GTCTTAGTCGTGACCACATGGCTGTTGTCAGGTCGTGCTGCGGTTGTCCCATTGGGGACT
TGGCGGCGACTGTCCCTGTGCTGGTTTGCAGTGTGTGGGTTCATTCACCTGGTGATCGAG
GGCTGGTTCGTTCTCTACTACGAAGACCTGCTTGGAGACCAAGCCTTCTTATCTCAACTC
TGGAAAGAGTATGCCAAGGGAGACAGCCGATACATCCTGGGTGACAACTTCACAGTGTGC
ATGGAAACCATCACAGCTTGCCTGTGGGGACCACTCAGCCTGTGGGTGGTGATCGCCTTT
CTCCGCCAGCATCCCCTCCGCTTCATTCTACAGCTTGTGGTCTCTGTGGGCCAGATCTAT
GGGGATGTGCTCTACTTCCTGACAGAGCACCGCGACGGATTCCAGCACGGAGAGCTGGGC
CACCCTCTCTACTTCTGGTTTTACTTTGTCTTCATGAATGCCCTGTGGCTGGTGCTGCCT
GGAGTCCTTGTGCTTGATGCTGTGAAGCACCTCACTCATGCCCAGAGCACGCTGGATGCC
AAGGCCACAAAAGCCAAGAGCAAGAAGAACTGA

Protein Properties

Number of Residues

230

Molecular Weight

26352.615

Theoretical pI

7.902

Pfam Domain Function

EBP (PF05241 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
MTTNAGPLHPYWPQHLRLDNFVPNDRPTWHILAGLFSVTGVLVVTTWLLSGRAAVVPLGT
WRRLSLCWFAVCGFIHLVIEGWFVLYYEDLLGDQAFLSQLWKEYAKGDSRYILGDNFTVC
METITACLWGPLSLWVVIAFLRQHPLRFILQLVVSVGQIYGDVLYFLTEHRDGFQHGELG
HPLYFWFYFVFMNALWLVLPGVLVLDAVKHLTHAQSTLDAKATKAKSKKN

External Links

GenBank ID Protein

5729810

UniProtKB/Swiss-Prot ID

Q15125

UniProtKB/Swiss-Prot Entry Name

EBP_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_006579.2

GeneCard ID