| Identification |
|---|
| HMDB Protein ID
| CDBP00878 |
| Secondary Accession Numbers
| Not Available |
| Name
| Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 |
| Description
| Not Available |
| Synonyms
|
- Beta-1,3-glucuronyltransferase 1
- GlcAT-P
- GlcUAT-P
- Glucuronosyltransferase P
- UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase
|
| Gene Name
| B3GAT1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity |
| Specific Function
| Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group (By similarity).
|
| GO Classification
|
| Biological Process |
| protein glycosylation |
| carbohydrate metabolic process |
| chondroitin sulfate metabolic process |
| Cellular Component |
| integral to membrane |
| Golgi membrane |
| Component |
| membrane |
| cell part |
| Function |
| catalytic activity |
| transferase activity |
| glucuronosyltransferase activity |
| galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity |
| udp-glycosyltransferase activity |
| transferase activity, transferring glycosyl groups |
| Molecular Function |
| metal ion binding |
| galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity |
| UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity |
|
| Cellular Location
|
- Golgi apparatus membrane
- Single-pass type II membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | protein glycosylation | Not Available | Not Available | | Other types of O-glycan biosynthesis | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| 11q25 |
| SNPs
| B3GAT1 |
| Gene Sequence
|
>1005 bp
ATGCCGAAGAGACGGGACATCCTAGCGATCGTCCTCATCGTGCTGCCCTGGACTCTGCTC
ATCACTGTCTGGCACCAGAGCACCCTCGCACCCCTGCTCGCGGTACATAAGGATGAGGGC
AGTGACCCCCGACGCGAAACGCCGCCCGGCGCCGACCCCAGGGAGTACTGCACGTCTGAC
CGCGACATCGTGGAGGTGGTGCGCACCGAGTACGTGTACACGCGGCCCCCGCCATGGTCC
GACACGCTGCCCACCATCCACGTGGTGACGCCCACCTACAGCCGCCCGGTGCAGAAGGCC
GAGCTGACGCGCATGGCCAACACGCTGCTGCACGTGCCCAACCTCCACTGGCTGGTGGTG
GAGGATGCGCCGCGCCGGACGCCGCTGACCGCGCGCCTGCTGCGCGACACCGGCCTCAAC
TACACGCACCTGCACGTGGAGACGCCCCGCAACTACAAGCTGCGCGGAGACGCCCGCGAC
CCACGCATCCCGCGGGGCACCATGCAGCGCAACCTGGCCCTGCGCTGGCTGCGCGAGACC
TTCCCGCGCAACTCCAGCCAGCCTGGCGTGGTCTACTTCGCCGACGACGACAACACCTAC
AGCCTGGAGCTCTTCGAAGAGATGCGCAGCACCAGGAGGGTGTCCGTGTGGCCCGTCGCC
TTCGTGGGTGGCCTGCGGTACGAGGCCCCACGGGTGAACGGGGCAGGGAAGGTGGTCCGC
TGGAAGACGGTGTTTGACCCCCACCGGCCATTTGCAATAGACATGGCTGGATTTGCCGTC
AACCTGCGGCTCATTCTGCAGCGAAGCCAGGCCTACTTCAAGCTGCGAGGTGTGAAGGGA
GGCTACCAGGAAAGCAGCCTCCTTCGAGAACTTGTCACCCTCAACGACCTGGAGCCCAAG
GCAGCCAACTGCACCAAGATCCTGGTGTGGCACACACGGACAGAGAAGCCAGTGCTGGTG
AATGAGGGCAAGAAGGGCTTCACTGACCCCTCGGTGGAGATCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 334 |
| Molecular Weight
| 38255.675 |
| Theoretical pI
| 9.617 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1
MPKRRDILAIVLIVLPWTLLITVWHQSTLAPLLAVHKDEGSDPRRETPPGADPREYCTSD
RDIVEVVRTEYVYTRPPPWSDTLPTIHVVTPTYSRPVQKAELTRMANTLLHVPNLHWLVV
EDAPRRTPLTARLLRDTGLNYTHLHVETPRNYKLRGDARDPRIPRGTMQRNLALRWLRET
FPRNSSQPGVVYFADDDNTYSLELFEEMRSTRRVSVWPVAFVGGLRYEAPRVNGAGKVVG
WKTVFDPHRPFAIDMAGFAVNLRLILQRSQAYFKLRGVKGGYQESSLLRELVTLNDLEPK
AANCTKILVWHTRTEKPVLVNEGKKGFTDPSVEI
|
| External Links |
|---|
| GenBank ID Protein
| 8051678 |
| UniProtKB/Swiss-Prot ID
| Q9P2W7 |
| UniProtKB/Swiss-Prot Entry Name
| B3GA1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AB029396 |
| GeneCard ID
| B3GAT1 |
| GenAtlas ID
| B3GAT1 |
| HGNC ID
| HGNC:921 |
| References |
|---|
| General References
| Not Available |