Cannabis Compound Database: Showing Protein Guanylate kinase (CDBP00873)

Identification Biological properties Gene properties Protein properties External links References XML Show 6 compounds

Identification

HMDB Protein ID

CDBP00873

Secondary Accession Numbers

Not Available

Name

Guanylate kinase

Description

Not Available

Synonyms

GMP kinase

Gene Name

GUK1

Protein Type

Enzyme

Biological Properties

General Function

Involved in guanylate kinase activity

Specific Function

Essential for recycling GMP and indirectly, cGMP.

GO Classification

Biological Process
drug metabolic process
nucleobase-containing small molecule interconversion
purine nucleotide metabolic process
Cellular Component
cytosol
Function
catalytic activity
phosphotransferase activity, phosphate group as acceptor
transferase activity
transferase activity, transferring phosphorus-containing groups
guanylate kinase activity
Molecular Function
guanylate kinase activity
ATP binding
Process
metabolic process
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
purine nucleotide metabolic process

Cellular Location

Not Available

Pathways

Name	SMPDB/Pathwhiz	KEGG
Purine Metabolism
Adenosine Deaminase Deficiency		Not Available
Adenylosuccinate Lyase Deficiency		Not Available
Gout or Kelley-Seegmiller Syndrome		Not Available
Lesch-Nyhan Syndrome (LNS)		Not Available

Gene Properties

Chromosome Location

Locus

1q32-q41

SNPs

GUK1

Gene Sequence

>594 bp
ATGTCGGGCCCCAGGCCTGTGGTGCTGAGCGGGCCTTCGGGAGCTGGGAAGAGCACCCTG
CTGAAGAGGCTGCTCCAGGAGCACAGCGGCATCTTTGGCTTCAGCGTGTCCCATACCACG
AGGAACCCGAGGCCCGGCGAGGAGAACGGCAAAGATTACTACTTTGTAACCAGGGAGGTG
ATGCAGCGTGACATAGCAGCCGGCGACTTCATCGAGCATGCCGAGTTCTCGGGGAACCTG
TATGGCACGAGCAAGGTGGCGGTGCAGGCCGTGCAGGCCATGAACCGCATCTGTGTGCTG
GACGTGGACCTGCAGGGTGTGCGGAACATCAAGGCCACCGATCTGCGGCCCATCTACATC
TCTGTGCAGCCGCCTTCACTGCACGTGCTGGAGCAGCGGCTGCGGCAGCGCAACACTGAA
ACCGAGGAGAGCCTGGTGAAGCGGCTGGCTGCTGCCCAGGCCGACATGGAGAGCAGCAAG
GAGCCCGGCCTGTTTGATGTGGTCATCATTAACGACAGCCTGGACCAGGCCTACGCAGAG
CTGAAGGAGGCGCTCTCTGAGGAAATCAAGAAAGCTCAAAGGACCGGCGCCTGA

Protein Properties

Number of Residues

197

Molecular Weight

21725.41

Theoretical pI

6.556

Pfam Domain Function

Guanylate_kin (PF00625 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Guanylate kinase
MSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREV
MQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYI
SVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAE
LKEALSEEIKKAQRTGA

External Links

GenBank ID Protein

1196436

UniProtKB/Swiss-Prot ID

Q16774

UniProtKB/Swiss-Prot Entry Name

KGUA_HUMAN

PDB IDs

Not Available

GenBank Gene ID

L76200

GeneCard ID