| Identification |
|---|
| HMDB Protein ID
| CDBP00867 |
| Secondary Accession Numbers
| Not Available |
| Name
| Poly [ADP-ribose] polymerase 4 |
| Description
| Not Available |
| Synonyms
|
- 193 kDa vault protein
- PARP-4
- PARP-related/IalphaI-related H5/proline-rich
- PH5P
- VPARP
- Vault poly(ADP-ribose) polymerase
- ADP-ribosyltransferase diphtheria toxin-like 4
- ARTD4
|
| Gene Name
| PARP4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in NAD+ ADP-ribosyltransferase activity |
| Specific Function
| Not Available |
| GO Classification
|
| Biological Process |
| protein ADP-ribosylation |
| transport |
| cell death |
| DNA repair |
| inflammatory response |
| response to drug |
| Cellular Component |
| cytoplasm |
| nucleus |
| spindle microtubule |
| ribonucleoprotein complex |
| Component |
| cell part |
| intracellular |
| Function |
| catalytic activity |
| transferase activity |
| nad+ adp-ribosyltransferase activity |
| transferase activity, transferring pentosyl groups |
| transferase activity, transferring glycosyl groups |
| Molecular Function |
| DNA binding |
| NAD+ ADP-ribosyltransferase activity |
| enzyme binding |
| Process |
| metabolic process |
| macromolecule metabolic process |
| protein amino acid adp-ribosylation |
| post-translational protein modification |
| macromolecule modification |
| protein modification process |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
- Cytoplasm
- cytoskeleton
- spindle
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Base excision repair | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 13 |
| Locus
| 13q11 |
| SNPs
| PARP4 |
| Gene Sequence
|
>5175 bp
ATGGTGATGGGAATCTTTGCAAATTGTATCTTCTGTTTGAAAGTGAAGTACTTACCTCAG
CAGCAGAAGAAAAAGCTACAAACTGACATTAAGGAAAATGGCGGAAAGTTTTCCTTTTCG
TTAAATCCTCAGTGCACACATATAATCTTAGATAATGCTGATGTTCTGAGTCAGTACCAA
CTGAATTCTATCCAAAAGAACCACGTTCATATTGCAAACCCAGATTTTATATGGAAATCT
ATCAGAGAAAAGAGACTCTTGGATGTAAAGAATTATGATCCTTATAAGCCCCTGGACATC
ACACCACCTCCTGATCAGAAGGCGAGCAGTTCTGAAGTGAAAACAGAAGGTCTATGCCCG
GACAGTGCCACAGAGGAGGAAGACACTGTGGAACTCACTGAGTTTGGTATGCAGAATGTT
GAAATTCCTCATCTTCCTCAAGATTTTGAAGTTGCAAAATATAACACCTTGGAGAAAGTG
GGAATGGAGGGAGGCCAGGAAGCTGTGGTGGTGGAGCTTCAGTGTTCGCGGGACTCCAGG
GACTGTCCTTTCCTGATATCCTCACACTTCCTCCTGGATGATGGCATGGAGACTAGAAGA
CAGTTTGCTATAAAGAAAACCTCTGAAGATGCAAGTGAATACTTTGAAAATTACATTGAA
GAACTGAAGAAACAAGGATTTCTACTAAGAGAACATTTCACACCTGAAGCAACCCAATTA
GCATCTGAACAATTGCAAGCATTGCTTTTGGAGGAAGTCATGAATTCAAGCACTCTGAGC
CAAGAGGTGAGCGATTTAGTAGAGATGATTTGGGCAGAGGCCCTGGGCCACCTGGAACAC
ATGCTTCTCAAGCCAGTGAACAGGATTAGCCTCAACGATGTGAGCAAGGCAGAGGGGATT
CTCCTTCTAGTAAAGGCAGCACTGAAAAATGGAGAAACAGCAGAGCAATTGCAAAAGATG
ATGACAGAGTTTTACAGACTGATACCTCACAAAGGCACAATGCCCAAAGAAGTGAACCTG
GGACTATTGGCTAAGAAAGCAGACCTCTGCCAGCTAATAAGAGACATGGTTAATGTCTGT
GAAACTAATTTGTCCAAACCCAACCCACCATCCCTGGCCAAATACCGAGCTTTGAGGTGC
AAAATTGAGCATGTTGAACAGAATACTGAAGAATTTCTCAGGGTTAGAAAAGAGGTTTTG
CAGAATCATCACAGTAAGAGCCCAGTGGATGTCTTGCAGATATTTAGAGTTGGCAGAGTG
AATGAAACCACAGAGTTTTTGAGCAAACTTGGTAATGTGAGGCCCTTGTTGCATGGTTCT
CCTGTACAAAACATCGTGGGAATCTTGTGTCGAGGGTTGCTTTTACCCAAAGTAGTGGAA
GATCGTGGTGTGCAAAGAACAGACGTCGGAAACCTTGGAAGTGGGATTTATTTCAGTGAT
TCGCTCAGTACAAGTATCAAGTACTCACACCCGGGAGAGACAGATGGCACCAGACTCCTG
CTCATTTGTGACGTAGCCCTCGGAAAGTGTATGGACTTACATGAGAAGGACTTTTCCTTA
ACTGAAGCACCACCAGGCTACGACAGTGTGCATGGAGTTTCACAAACAGCCTCTGTCACC
ACAGACTTTGAGGATGATGAATTTGTTGTCTATAAAACCAATCAGGTTAAAATGAAATAT
ATTATTAAATTTTCCATGCCTGGAGATCAGATAAAGGACTTTCATCCTAGTGATCATACT
GAATTAGAGGAATACAGACCTGAGTTTTCAAATTTTTCAAAGGTTGAAGATTACCAGTTA
CCAGATGCCAAAACTTCCAGCAGCACCAAGGCCGGCCTCCAGGATGCTTCTGGGAACTTG
GTTCCTCTGGAGGATGTCCACATCAAAGGGAGAATCATAGACACTGTAGCCCAGGTCATT
GTTTTTCAGACATACACAAATAAAAGTCACGTGCCCATTGAGGCAAAATATATCTTTCCT
TTGGATGACAAGGCCGCTGTGTGTGGCTTCGAAGCCTTCATCAATGGGAAGCACATAGTT
GGAGAGATTAAAGAGAAGGAAGAAGCCCAGCAAGAGTACCTAGAAGCCGTGACCCAGGGC
CATGGCGCTTACCTGATGAGTCAGGATGCTCCGGACGTTTTTACTGTAAGTGTTGGAAAC
TTACCCCCTAAGGCTAAGGTTCTTATAAAAATTACCTACATCACAGAACTCAGCATCCTG
GGCACTGTTGGTGTCTTTTTCATGCCCGCCACCGTAGCACCCTGGCAACAGGACAAGGCT
TTGAATGAAAACCTTCAGGATACAGTAGAGAAGATTTGTATAAAAGAAATAGGAACAAAG
CAAAGCTTCTCTTTGACTATGTCTATTGAGATGCCGTACGTGATTGAATTCATTTTCAGT
GATACTCATGAACTGAAACAAAAGCGCACAGACTGCAAAGCTGTCATTAGCACCATGGAA
GGCAGCTCCTTAGACAGCAGTGGATTTTCTCTCCACATCGGTTTGTCTGCTGCCTATCTC
CCAAGAATGTGGGTTGAAAAACATCCAGAAAAAGAAAGCGAGGCTTGCATGCTTGTCTTT
CAACCCGATCTCGATGTCGACCTCCCTGACCTAGCCAATGAGAGCGAAGTGATTATTTGT
CTTGACTGCTCCAGTTCCATGGAGGGTGTGACATTCTTGCAAGCCAAGGAAATCGCCTTG
CATGCGCTGTCCTTGGTGGGTGAGAAGCAGAAAGTAAATATTATCCAGTTCGGCACAGGT
TACAAGGAGCTATTTTCGTATCCTAAGCATATCACAAGCAATACCGCGGCAGCAGAGTTC
ATCATGTCTGCCACACCTACCATGGGGAACACAGACTTCTGGAAAACACTCCGATATCTT
AGCTTATTGTACCCTGCTCGAGGGTCACGGAACATCCTCCTGGTGTCTGATGGGCACCTC
CAGGATGAGAGCCTGACATTACAGCTCGTGAAGAGGAGCCGCCCGCACACCAGGTTATTC
GCCTGCGGTATCGGTTCTACAGCAAATCGTCACGTCTTAAGGATTTTGTCCCAGTGTGGT
GCCGGAGTATTTGAATATTTTAATGCAAAATCCAAGCATAGTTGGAGAAAACAGATAGAA
GACCAAATGACCAGGCTATGTTCTCCGAGTTGCCACTCTGTCTCCGTCAAATGGCAGCAA
CTCAATCCAGATGCGCCCGAGGCCCTGCAGGCCCCAGCCCAGGTGCCATCCTTGTTTCGC
AATGATCGACTCCTTGTCTATGGATTCATTCCTCACTGCACACAGGCAACTCTGTGTGCA
CTAATTCAAGAGAAAGAATTTTGTACAATGGTGTCGACTACTGAGCTTCAGAAGACAACT
GGAACTATGATCCACAAGCTGGCAGCCCGAGCTCTAATCAGAGATTATGAAGATGGCATT
CTTCACGAAAATGAAACCAGTCATGAGATGAAAAAACAAACCTTGAAATCTCTGATTATT
AAACTCAGTAAAGAAAACTCTCTCATAACACAATTTACAAGCTTTGTGGCAGTTGAGAAA
AGGGATGAGAATGAGTCACCTTTTCCTGATATTCCAAAAGTTTCTGAACTTATTGCCAAA
GAAGATGTAGACTTCCTGCCCTACATGAGCTGGCAGGGGGAACCCCAAGAAGCCGTCAGG
AACCAGTCTCTTTTAGCATCCTCTGAGTGGCCAGAATTACGTTTATCCAAACGAAAACAT
AGGAAAATTCCATTTTCCAAAAGAAAAATGGAATTATCTCAGCCAGAAGTTTCTGAAGAT
TTTGAAGAGGATGCCTTAGGTGTACTACCAGCTTTCACATCAAATTTGGAACGTGGACGT
GTGGAAAAGCTATTGGATTTAAGTTGGACAGAGTCATGTAAACCAACAGCAACTGAACCA
CTATTTAAGAAAGTCAGTCCATGGGAAACATCTACTTCTAGCTTTTTTCCTATTTTGGCT
CCGGCCGTTGGTTCCTATCTTACCCCGACTACCCGCGCTCACAGTCCTGCTTCCTTGTCT
TTTGCCTCATATCGTCAGGTAGCTAGTTTCGGTTCAGCTGCTCCTCCCAGACAGTTTGAT
GCATCTCAATTCAGCCAAGGCCCTGTGCCTGGCACTTGTGCTGACTGGATCCCACAGTCG
GCGTCTTGTCCCACAGGACCTCCCCAGAACCCACCTTCTGCACCCTATTGTGGCATTGTT
TTTTCAGGGAGCTCATTAAGCTCTGCACAGTCTGCTCCACTGCAACATCCTGGAGGCTTT
ACTACCAGGCCTTCTGCTGGCACCTTCCCTGAGCTGGATTCTCCCCAGCTTCATTTCTCT
CTTCCTACAGACCCTGATCCCATCAGAGGTTTTGGGTCTTATCATCCCTCTGCTTACTCT
CCTTTTCATTTTCAACCTTCCGCAGCCTCTTTGACTGCCAACCTTAGGCTGCCAATGGCC
TCTGCTTTACCTGAGGCTCTTTGCAGTCAGTCCCGGACTACCCCAGTAGATCTCTGTCTT
CTAGAAGAATCAGTAGGCAGTCTCGAAGGAAGTCGATGTCCTGTCTTTGCTTTTCAAAGT
TCTGACACAGAAAGTGATGAGCTATCAGAAGTACTTCAAGACAGCTGCTTTTTACAAATA
AAATGTGATACAAAAGATGACAGTATCCCGTGCTTTCTGGAAGTAAAAGAAGAGGATGAA
ATAGTGTGCACACAACACTGGCAGGATGCTGTGCCTTGGACAGAACTCCTCAGTCTACAG
ACAGAGGATGGCTTCTGGAAACTTACACCAGAACTGGGACTTATATTAAATCTTAATACA
AATGGTTTGCACAGCTTTCTTAAACAAAAAGGCATTCAATCTCTAGGTGTAAAAGGAAGA
GAATGTCTCCTGGACCTAATTGCCACAATGCTGGTACTACAGTTTATTCGCACCAGGTTG
GAAAAAGAGGGAATAGTGTTCAAATCACTGATGAAAATGGATGACCCTTCTATTTCCAGG
AATATTCCCTGGGCTTTTGAGGCAATAAAGCAAGCAAGTGAATGGGTAAGAAGAACTGAA
GGACAGTACCCATCTATCTGCCCACGGCTTGAACTGGGGAACGACTGGGACTCTGCCACC
AAGCAGTTGCTGGGACTCCAGCCCATAAGCACTGTGTCCCCTCTTCATAGAGTCCTCCAT
TACAGTCAAGGCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 1724 |
| Molecular Weight
| 192592.915 |
| Theoretical pI
| 5.653 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Poly [ADP-ribose] polymerase 4
MVMGIFANCIFCLKVKYLPQQQKKKLQTDIKENGGKFSFSLNPQCTHIILDNADVLSQYQ
LNSIQKNHVHIANPDFIWKSIREKRLLDVKNYDPYKPLDITPPPDQKASSSEVKTEGLCP
DSATEEEDTVELTEFGMQNVEIPHLPQDFEVAKYNTLEKVGMEGGQEAVVVELQCSRDSR
DCPFLISSHFLLDDGMETRRQFAIKKTSEDASEYFENYIEELKKQGFLLREHFTPEATQL
ASEQLQALLLEEVMNSSTLSQEVSDLVEMIWAEALGHLEHMLLKPVNRISLNDVSKAEGI
LLLVKAALKNGETAEQLQKMMTEFYRLIPHKGTMPKEVNLGLLAKKADLCQLIRDMVNVC
ETNLSKPNPPSLAKYRALRCKIEHVEQNTEEFLRVRKEVLQNHHSKSPVDVLQIFRVGRV
NETTEFLSKLGNVRPLLHGSPVQNIVGILCRGLLLPKVVEDRGVQRTDVGNLGSGIYFSD
SLSTSIKYSHPGETDGTRLLLICDVALGKCMDLHEKDFSLTEAPPGYDSVHGVSQTASVT
TDFEDDEFVVYKTNQVKMKYIIKFSMPGDQIKDFHPSDHTELEEYRPEFSNFSKVEDYQL
PDAKTSSSTKAGLQDASGNLVPLEDVHIKGRIIDTVAQVIVFQTYTNKSHVPIEAKYIFP
LDDKAAVCGFEAFINGKHIVGEIKEKEEAQQEYLEAVTQGHGAYLMSQDAPDVFTVSVGN
LPPKAKVLIKITYITELSILGTVGVFFMPATVAPWQQDKALNENLQDTVEKICIKEIGTK
QSFSLTMSIEMPYVIEFIFSDTHELKQKRTDCKAVISTMEGSSLDSSGFSLHIGLSAAYL
PRMWVEKHPEKESEACMLVFQPDLDVDLPDLASESEVIICLDCSSSMEGVTFLQAKQIAL
HALSLVGEKQKVNIIQFGTGYKELFSYPKHITSNTMAAEFIMSATPTMGNTDFWKTLRYL
SLLYPARGSRNILLVSDGHLQDESLTLQLVKRSRPHTRLFACGIGSTANRHVLRILSQCG
AGVFEYFNAKSKHSWRKQIEDQMTRLCSPSCHSVSVKWQQLNPDVPEALQAPAQVPSLFL
NDRLLVYGFIPHCTQATLCALIQEKEFRTMVSTTELQKTTGTMIHKLAARALIRDYEDGI
LHENETSHEMKKQTLKSLIIKLSKENSLITQFTSFVAVEKRDENESPFPDIPKVSELIAK
EDVDFLPYMSWQGEPQEAVRNQSLLASSEWPELRLSKRKHRKIPFSKRKMELSQPEVSED
FEEDGLGVLPAFTSNLERGGVEKLLDLSWTESCKPTATEPLFKKVSPWETSTSSFFPILA
PAVGSYLPPTARAHSPASLSFASYRQVASFGSAAPPRQFDASQFSQGPVPGTCADWIPQS
ASCPTGPPQNPPSSPYCGIVFSGSSLSSAQSAPLQHPGGFTTRPSAGTFPELDSPQLHFS
LPTDPDPIRGFGSYHPSASSPFHFQPSAASLTANLRLPMASALPEALCSQSRTTPVDLCL
LEESVGSLEGSRCPVFAFQSSDTESDELSEVLQDSCFLQIKCDTKDDSILCFLEVKEEDE
IVCIQHWQDAVPWTELLSLQTEDGFWKLTPELGLILNLNTNGLHSFLKQKGIQSLGVKGR
ECLLDLIATMLVLQFIRTRLEKEGIVFKSLMKMDDASISRNIPWAFEAIKQASEWVRRTE
GQYPSICPRLELGNDWDSATKQLLGLQPISTVSPLHRVLHYSQG
|
| External Links |
|---|
| GenBank ID Protein
| 3694920 |
| UniProtKB/Swiss-Prot ID
| Q9UKK3 |
| UniProtKB/Swiss-Prot Entry Name
| PARP4_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF057160 |
| GeneCard ID
| PARP4 |
| GenAtlas ID
| PARP4 |
| HGNC ID
| HGNC:271 |
| References |
|---|
| General References
| Not Available |