Cannabis Compound Database: Showing Protein Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (CDBP00863)

Identification Biological properties Gene properties Protein properties External links References XML Show 10 compounds

Identification

HMDB Protein ID

CDBP00863

Secondary Accession Numbers

Not Available

Name

Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial

Description

Not Available

Synonyms

Methenyltetrahydrofolate cyclohydrolase
NAD-dependent methylenetetrahydrofolate dehydrogenase

Gene Name

MTHFD2

Protein Type

Enzyme

Biological Properties

General Function

Involved in catalytic activity

Specific Function

Not Available

GO Classification

Biological Process
folic acid-containing compound biosynthetic process
tetrahydrofolate metabolic process
one-carbon metabolic process
response to heat
Cellular Component
mitochondrion
Function
binding
catalytic activity
Molecular Function
magnesium ion binding
methylenetetrahydrofolate dehydrogenase (NAD+) activity
methenyltetrahydrofolate cyclohydrolase activity
methylenetetrahydrofolate dehydrogenase (NADP+) activity
phosphate ion binding
nucleotide binding
Process
folic acid and derivative biosynthetic process
metabolic process
cellular aromatic compound metabolic process
folic acid and derivative metabolic process
cellular metabolic process

Cellular Location

Mitochondrion

Pathways

Name	SMPDB/Pathwhiz	KEGG
One carbon pool by folate	Not Available
Folate Metabolism
Methotrexate Action Pathway		Not Available
Folate malabsorption, hereditary		Not Available

Gene Properties

Chromosome Location

Locus

2p13.1

SNPs

MTHFD2

Gene Sequence

>1053 bp
ATGGCTGCGACTTCTCTAATGTCTGCTTTGGCTGCCCGGCTGCTGCAGCCCGCGCACAGC
TGCTCCCTTCGCCTTCGCCCTTTCCACCTCGCGGCAGTTCGAAATGAAGCTGTTGTCATT
TCTGGAAGGAAACTGGCCCAGCAGATCAAGCAGGAAGTGCGGCAGGAGGTAGAAGAGTGG
GTGGCCTCAGGCAACAAACGGCCACACCTGAGTGTGATCCTGGTTGGCGAGAATCCTGCA
AGTCACTCCTATGTCCTCAACAAAACCAGGGCAGCTGCAGTTGTGGGAATCAACAGTGAG
ACAATTATGAAACCAGCTTCAATTTCAGAGGAAGAATTGTTGAATTTAATCAATAAACTG
AATAATGATGATAATGTAGATGGCCTCCTTGTTCAGTTGCCTCTTCCAGAGCATATTGAT
GAGAGAAGGATCTGCAATGCTGTTTCTCCAGACAAGGATGTTGATGGCTTTCATGTAATT
AATGTAGGACGAATGTGTTTGGATCAGTATTCCATGTTACCGGCTACTCCATGGGGTGTG
TGGGAAATAATCAAGCGAACTGGCATTCCAACCCTAGGGAAGAATGTGGTTGTGGCTGGA
AGGTCAAAAAACGTTGGAATGCCCATTGCAATGTTACTGCACACAGATGGGGCGCATGAA
CGTCCCGGAGGTGATGCCACTGTTACAATATCTCATCGATATACTCCCAAAGAGCAGTTG
AAGAAACATACAATTCTTGCAGATATTGTAATATCTGCTGCAGGTATTCCAAATCTGATC
ACAGCAGATATGATCAAGGAAGGAGCAGCAGTCATTGATGTGGGAATAAATAGAGTTCAC
GATCCTGTAACTGCCAAACCCAAGTTGGTTGGAGATGTGGATTTTGAAGGAGTCAGACAA
AAAGCTGGGTATATCACTCCAGTTCCTGGAGGTGTTGGCCCCATGACAGTGGCAATGCTA
ATGAAGAATACCATTATTGCTGCAAAAAAGGTGCTGAGGCTTGAAGAGCGAGAAGTGCTG
AAGTCTAAAGAGCTTGGGGTAGCCACTAATTAA

Protein Properties

Number of Residues

350

Molecular Weight

37894.775

Theoretical pI

8.73

Pfam Domain Function

THF_DHG_CYH (PF00763 )
THF_DHG_CYH_C (PF02882 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
MAATSLMSALAARLLQPAHSCSLRLRPFHLAAVRNEAVVISGRKLAQQIKQEVRQEVEEW
VASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVGINSETIMKPASISEEELLNLINKL
NNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDGFHVINVGRMCLDQYSMLPATPWGV
WEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYTPKEQL
KKHTILADIVISAAGIPNLITADMIKEGAAVIDVGINRVHDPVTAKPKLVGDVDFEGVRQ
KAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRLEEREVLKSKELGVATN

External Links

GenBank ID Protein

94721354

UniProtKB/Swiss-Prot ID

P13995

UniProtKB/Swiss-Prot Entry Name

MTDC_HUMAN

PDB IDs