| Identification |
|---|
| HMDB Protein ID
| CDBP00858 |
| Secondary Accession Numbers
| Not Available |
| Name
| ADP-ribosyl cyclase 2 |
| Description
| Not Available |
| Synonyms
|
- BST-1
- Bone marrow stromal antigen 1
- CD157 antigen
- Cyclic ADP-ribose hydrolase 2
- cADPr hydrolase 2
|
| Gene Name
| BST1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in NAD+ nucleosidase activity |
| Specific Function
| Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.
|
| GO Classification
|
| Biological Process |
| multicellular organismal development |
| humoral immune response |
| Cellular Component |
| anchored to membrane |
| plasma membrane |
| extrinsic to membrane |
| Function |
| binding |
| catalytic activity |
| hydrolase activity |
| hydrolase activity, acting on glycosyl bonds |
| hydrolase activity, hydrolyzing n-glycosyl compounds |
| nad+ nucleosidase activity |
| Molecular Function |
| NAD+ nucleosidase activity |
| nucleotide binding |
| Process |
| metabolic process |
|
| Cellular Location
|
- Cell membrane
- Lipid-anchor
- GPI-anchor
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Nicotinate and Nicotinamide Metabolism |    |  | | Calcium signaling pathway | Not Available |  | | Salivary secretion | Not Available |  | | Pancreatic secretion | Not Available |  | | Epstein-Barr virus infection | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 4 |
| Locus
| 4p15 |
| SNPs
| BST1 |
| Gene Sequence
|
>957 bp
ATGGCGGCCCAGGGGTGCGCGGCATCGCGGCTGCTCCAGCTGCTGCTGCAGCTTCTGCTT
CTACTGTTGCTGCTGGCGGCGGGCGGGGCGCGCGCGCGGTGGCGCGGGGAGGGCACCAGC
GCACACTTGCGGGACATCTTCCTGGGCCGCTGCGCCGAGTACCGCGCACTGCTGAGTCCC
GAGCAGCGGAACAAGAACTGCACAGCCATCTGGGAAGCCTTTAAAGTGGCGCTGGACAAG
GATCCCTGCTCCGTGCTGCCCTCAGACTATGACCTTTTTATTAACTTGTCCAGGCACTCT
ATTCCCAGAGATAAGTCCCTGTTCTGGGAAAATAGCCACCTCCTTGTTAACAGCTTTGCA
GACAACACCCGTCGTTTTATGCCCCTGAGCGATGTTCTGTATGGCAGGGTTGCAGATTTC
TTGAGCTGGTGTCGACAGAAAAATGACTCTGGACTCGATTACCAATCCTGCCCTACATCA
GAAGACTGTGAAAATAATCCTGTGGATTCCTTTTGGAAAAGGGCATCCATCCAGTATTCC
AAGGATAGTTCTGGGGTGATCCACGTCATGCTGAATGGTTCAGAGCCAACAGGAGCCTAT
CCCATCAAAGGTTTTTTTGCAGATTATGAAATTCCAAACCTCCAGAAGGAAAAAATTACA
CGAATCGAGATCTGGGTTATGCATGAAATTGGGGGACCCAATGTGGAATCCTGCGGGGAA
GGCAGCATGAAAGTCCTGGAAAAGAGGCTGAAGGACATGGGGTTCCAGTACAGCTGTATT
AATGATTACCGACCAGTGAAGCTCTTACAGTGCGTGGACCACAGCACCCATCCTGACTGT
GCCTTAAAGTCGGCAGCAGCCGCTACTCAAAGAAAAGCCCCAAGTCTTTATACAGAACAA
AGGGCGGGTCTTATCATTCCCCTCTTTCTGGTGCTGGCTTCCAGGACTCAACTGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 318 |
| Molecular Weight
| 35723.545 |
| Theoretical pI
| 7.794 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>ADP-ribosyl cyclase 2
MAAQGCAASRLLQLLLQLLLLLLLLAAGGARARWRGEGTSAHLRDIFLGRCAEYRALLSP
EQRNKNCTAIWEAFKVALDKDPCSVLPSDYDLFINLSRHSIPRDKSLFWENSHLLVNSFA
DNTRRFMPLSDVLYGRVADFLSWCRQKNDSGLDYQSCPTSEDCENNPVDSFWKRASIQYS
KDSSGVIHVMLNGSEPTGAYPIKGFFADYEIPNLQKEKITRIEIWVMHEIGGPNVESCGE
GSMKVLEKRLKDMGFQYSCINDYRPVKLLQCVDHSTHPDCALKSAAAATQRKAPSLYTEQ
RAGLIIPLFLVLASRTQL
|
| External Links |
|---|
| GenBank ID Protein
| 63991381 |
| UniProtKB/Swiss-Prot ID
| Q10588 |
| UniProtKB/Swiss-Prot Entry Name
| BST1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AC114744 |
| GeneCard ID
| BST1 |
| GenAtlas ID
| BST1 |
| HGNC ID
| HGNC:1118 |
| References |
|---|
| General References
| Not Available |