Cannabis Compound Database: Showing Protein Isocitrate dehydrogenase [NADP], mitochondrial (CDBP00839)

Identification Biological properties Gene properties Protein properties External links References XML Show 7 compounds

Identification

HMDB Protein ID

CDBP00839

Secondary Accession Numbers

Not Available

Name

Isocitrate dehydrogenase [NADP], mitochondrial

Description

Not Available

Synonyms

ICD-M
IDH
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase

Gene Name

IDH2

Protein Type

Enzyme

Biological Properties

General Function

Involved in magnesium ion binding

Specific Function

Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex.

GO Classification

Biological Process
2-oxoglutarate metabolic process
glyoxylate cycle
tricarboxylic acid cycle
isocitrate metabolic process
carbohydrate metabolic process
Cellular Component
mitochondrial matrix
mitochondrial inner membrane
Function
nad or nadh binding
oxidoreductase activity, acting on the ch-oh group of donors, nad or nadp as acceptor
oxidoreductase activity, acting on ch-oh group of donors
oxidoreductase activity
ion binding
cation binding
metal ion binding
binding
nucleotide binding
catalytic activity
isocitrate dehydrogenase activity
isocitrate dehydrogenase (nadp+) activity
magnesium ion binding
Molecular Function
NAD binding
magnesium ion binding
isocitrate dehydrogenase (NADP+) activity
Process
metabolic process
isocitrate metabolic process
cellular metabolic process
organic acid metabolic process
oxoacid metabolic process
carboxylic acid metabolic process
oxidation reduction

Cellular Location

Mitochondrion

Pathways

Name	SMPDB/Pathwhiz	KEGG
Citrate cycle (TCA cycle)	Not Available
2-Oxocarboxylic acid metabolism	Not Available
Peroxisome	Not Available
The oncogenic action of 2-hydroxyglutarate		Not Available
The Oncogenic Action of Succinate		Not Available

Gene Properties

Chromosome Location

Locus

15q26.1

SNPs

IDH2

Gene Sequence

>1359 bp
ATGGCCGGCTACCTGCGGGTCGTGCGCTCGCTCTGCAGAGCCTCAGGCTCGCGGCCGGCC
TGGGCGCCGGCGGCCCTGACAGCCCCCACCTCGCAAGAGCATCCGCGGCGCCACTATGCC
GACAAAAGGATCAAGGTGGCGAAGCCCGTGGTGGAGATGGATGGTGATGAGATGACCCGT
ATTATCTGGCAGTTCATCAAGGAGAAGCTCATCCTGCCCCACGTGGACATCCAGCTAAAG
TATTTTGACCTCGGGCTCCCAAACCGTGACCAGACTGATGACCAGGTCACCATTGACTCT
GCACTGGCCACCCAGAAGTACAGTGTGGCTGTCAAGTGTGCCACCATCACCCCTGATGAG
GCCCGTGTGGAAGAGTTCAAGCTGAAGAAGATGTGGAAAAGTCCCAATGGAACTATCCGG
AACATCCTGGGGGGGACTGTCTTCCGGGAGCCCATCATCTGCAAAAACATCCCACGCCTA
GTCCCTGGCTGGACCAAGCCCATCACCATTGGCAGGCACGCCCATGGCGACCAGTACAAG
GCCACAGACTTTGTGGCAGACCGGGCCGGCACTTTCAAAATGGTCTTCACCCCAAAAGAT
GGCAGTGGTGTCAAGGAGTGGGAAGTGTACAACTTTCCCGCAGGCGGCGTGGGCATGGGC
ATGTACAACACCGACGAGTCCATCTCAGGTTTTGCGCACAGCTGCTTCCAGTATGCCATC
CAGAAGAAATGGCCGCTGTACATGAGCACCAAGAACACCATACTGAAAGCCTACGATGGG
CGTTTCAAGGACATCTTCCAGGAGATCTTTGACAAGCACTATAAGACCGACTTCGACAAG
AATAAGATCTGGTATGAGCACCGGCTCATTGATGACATGGTGGCTCAGGTCCTCAAGTCT
TCGGGTGGCTTTGTGTGGGCCTGCAAGAACTATGACGGAGATGTGCAGTCAGACATCCTG
GCCCAGGGCTTTGGCTCCCTTGGCCTGATGACGTCCGTCCTGGTCTGCCCTGATGGGAAG
ACGATTGAGGCTGAGGCCGCTCATGGGACCGTCACCCGCCACTATCGGGAGCACCAGAAG
GGCCGGCCCACCAGCACCAACCCCATCGCCAGCATCTTTGCCTGGACACGTGGCCTGGAG
CACCGGGGGAAGCTGGATGGGAACCAAGACCTCATCAGGTTTGCCCAGATGCTGGAGAAG
GTGTGCGTGGAGACGGTGGAGAGTGGAGCCATGACCAAGGACCTGGCGGGCTGCATTCAC
GGCCTCAGCAATGTGAAGCTGAACGAGCACTTCCTGAACACCATGGACTTCCTCGACACC
ATCAAGAGCAACCTGGACAGAGCCCTGGGCAGGCAGTAG

Protein Properties

Number of Residues

452

Molecular Weight

50908.915

Theoretical pI

8.695

Pfam Domain Function

Iso_dh (PF00180 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Isocitrate dehydrogenase [NADP], mitochondrial
MAGYLRVVRSLCRASGSRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTR
IIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDE
ARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYK
ATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAI
QKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKS
SGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQK
GRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIH
GLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ

External Links

GenBank ID Protein

872121

UniProtKB/Swiss-Prot ID

P48735

UniProtKB/Swiss-Prot Entry Name

IDHP_HUMAN

PDB IDs

Not Available

GenBank Gene ID

X69433

GeneCard ID