Cannabis Compound Database: Showing Protein Tissue alpha-L-fucosidase (CDBP00818)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP00818

Secondary Accession Numbers

Not Available

Name

Tissue alpha-L-fucosidase

Description

Not Available

Synonyms

Alpha-L-fucosidase 1
Alpha-L-fucosidase I
Alpha-L-fucoside fucohydrolase 1

Gene Name

FUCA1

Protein Type

Enzyme

Biological Properties

General Function

Involved in alpha-L-fucosidase activity

Specific Function

Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

GO Classification

Biological Process
fucose metabolic process
glycosaminoglycan catabolic process
Cellular Component
cytoplasm
lysosome
Function
catalytic activity
hydrolase activity
hydrolase activity, acting on glycosyl bonds
hydrolase activity, hydrolyzing o-glycosyl compounds
fucosidase activity
alpha-l-fucosidase activity
Molecular Function
alpha-L-fucosidase activity
cation binding
Process
small molecule metabolic process
alcohol metabolic process
monosaccharide metabolic process
hexose metabolic process
metabolic process
fucose metabolic process
primary metabolic process
carbohydrate metabolic process

Cellular Location

Lysosome

Pathways

Name	SMPDB/Pathwhiz	KEGG
Other glycan degradation	Not Available
Lysosome	Not Available

Gene Properties

Chromosome Location

Locus

1p34

SNPs

FUCA1

Gene Sequence

>1401 bp
ATGCGGGCTCCGGGGATGAGGTCGCGGCCGGCGGGTCCCGCGCTGTTGCTGCTGCTGCTC
TTCCTCGGAGCGGCCGAGTCGGTGCGTCGGGCCCAGCCTCCGCGCCGCTACACCCCAGAC
TGGCCGAGCCTGGATTCTCGGCCGCTGCCGGCCTGGTTCGACGAAGCCAAGTTCGGGGTG
TTCATCCACTGGGGCGTGTTCTCGGTGCCCGCCTGGGGCAGCGAGTGGTTCTGGTGGCAC
TGGCAGGGCGAGGGGCGGCCGCAGTACCAGCGCTTCATGCGCGACAACTACCCGCCCGGC
TTCAGCTACGCCGACTTCGGACCGCAGTTCACTGCGCGCTTCTTCCACCCGGAGGAGTGG
GCCGACCTCTTCCAGGCCGCGGGCGCCAAGTATGTAGTTTTGACGACAAAGCATCACGAA
GGCTTCACAAACTGGCCGAGTCCTGTGTCTTGGAACTGGAACTCCAAAGACGTGGGGCCT
CATCGGGATTTGGTTGGTGAATTGGGAACAGCTCTCCGGAAGAGGAACATCCGCTATGGA
CTATACCACTCACTCTTAGAGTGGTTCCATCCACTCTATCTACTTGATAAGAAAAATGGC
TTCAAAACACAGCATTTTGTCAGTGCAAAAACAATGCCAGAGCTGTACGACCTTGTTAAC
AGCTATAAACCTGATCTGATCTGGTCTGATGGGGAGTGGGAATGTCCTGATACTTACTGG
AACTCCACAAATTTTCTTTCATGGCTCTACAATGACAGCCCTGTCAAGGATGAGGTGGTA
GTAAATGACCGATGGGGTCAGAACTGTTCCTGTCACCATGGAGGATACTATAACTGTGAA
GATAAATTCAAGCCACAGAGCTTGCCAGATCACAAGTGGGAGATGTGCACCAGCATTGAC
AAGTTTTCCTGGGGCTATCGTCGTGACATGGCATTGTCTGATGTTACAGAAGAATCTGAA
ATCATTTCGGAACTGGTTCAGACAGTAAGTTTGGGAGGCAACTATCTTCTGAACATTGGA
CCAACTAAAGATGGACTGATTGTTCCCATCTTCCAAGAAAGGCTTCTTGCTGTTGGGAAA
TGGCTGAGCATCAATGGGGAGGCTATCTATGCCTCCAAACCATGGCGGGTGCAATGGGAA
AAGAACACAACATCTGTATGGTATACCTCAAAGGGATCGGCTGTTTATGCCATTTTTCTG
CACTGGCCAGAAAATGGAGTCTTAAACCTTGAATCCCCCATAACTACCTCAACTACAAAG
ATAACAATGCTGGGAATTCAAGGAGATCTGAAGTGGTCCACAGATCCAGATAAAGGTCTC
TTCATCTCTCTACCCCAGTTGCCACCCTCTGCTGTCCCCGCAGAGTTTGCTTGGACTATA
AAGCTGACAGGAGTGAAGTAA

Protein Properties

Number of Residues

466

Molecular Weight

53688.475

Theoretical pI

6.848

Pfam Domain Function

Alpha_L_fucos (PF01120 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Tissue alpha-L-fucosidase
MRAPGMRSRPAGPALLLLLLFLGAAESVRRAQPPRRYTPDWPSLDSRPLPAWFDEAKFGV
FIHWGVFSVPAWGSEWFWWHWQGEGRPQYQRFMRDNYPPGFSYADFGPQFTARFFHPEEW
ADLFQAAGAKYVVLTTKHHEGFTNWPSPVSWNWNSKDVGPHRDLVGELGTALRKRNIRYG
LYHSLLEWFHPLYLLDKKNGFKTQHFVSAKTMPELYDLVNSYKPDLIWSDGEWECPDTYW
NSTNFLSWLYNDSPVKDEVVVNDRWGQNCSCHHGGYYNCEDKFKPQSLPDHKWEMCTSID
KFSWGYRRDMALSDVTEESEIISELVQTVSLGGNYLLNIGPTKDGLIVPIFQERLLAVGK
WLSINGEAIYASKPWRVQWEKNTTSVWYTSKGSAVYAIFLHWPENGVLNLESPITTSTTK
ITMLGIQGDLKWSTDPDKGLFISLPQLPPSAVPAEFAWTIKLTGVK

External Links

GenBank ID Protein

76879796

UniProtKB/Swiss-Prot ID

P04066

UniProtKB/Swiss-Prot Entry Name

FUCO_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AB074175

GeneCard ID