Cannabis Compound Database: Showing Protein Beta-hexosaminidase subunit alpha (CDBP00815)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP00815

Secondary Accession Numbers

Not Available

Name

Beta-hexosaminidase subunit alpha

Description

Not Available

Synonyms

Beta-N-acetylhexosaminidase subunit alpha
Hexosaminidase subunit A
N-acetyl-beta-glucosaminidase subunit alpha

Gene Name

HEXA

Protein Type

Enzyme

Biological Properties

General Function

Involved in beta-N-acetylhexosaminidase activity

Specific Function

Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. The form B is active against certain oligosaccharides. The form S has no measurable activity.

GO Classification

Biological Process
adult walking behavior
neuromuscular process controlling posture
skeletal system development
cell morphogenesis involved in neuron differentiation
ganglioside catabolic process
sexual reproduction
carbohydrate metabolic process
glycosphingolipid metabolic process
cell death
myelination
chondroitin sulfate catabolic process
sensory perception of sound
lysosome organization
neuromuscular process controlling balance
lipid storage
phospholipid metabolic process
keratan sulfate catabolic process
hyaluronan catabolic process
Cellular Component
lysosomal lumen
membrane
Function
beta-n-acetylhexosaminidase activity
binding
catalytic activity
hydrolase activity
hydrolase activity, acting on glycosyl bonds
hydrolase activity, hydrolyzing o-glycosyl compounds
ion binding
cation binding
hexosaminidase activity
Molecular Function
cation binding
beta-N-acetylhexosaminidase activity
protein heterodimerization activity
Process
metabolic process
primary metabolic process
carbohydrate metabolic process

Cellular Location

Lysosome

Pathways

Name	SMPDB/Pathwhiz	KEGG
Other glycan degradation	Not Available
Amino sugar and nucleotide sugar metabolism	Not Available
Glycosaminoglycan degradation	Not Available
Glycosphingolipid biosynthesis - globo series	Not Available
Glycosphingolipid biosynthesis - ganglio series	Not Available

Gene Properties

Chromosome Location

Not Available

Locus

Not Available

SNPs

HEXA

Gene Sequence

>1590 bp
ATGACAAGCTCCAGGCTTTGGTTTTCGCTGCTGCTGGCGGCAGCGTTCGCAGGACGGGCG
ACGGCCCTCTGGCCCTGGCCTCAGAACTTCCAAACCTCCGACCAGCGCTACGTCCTTTAC
CCGAACAACTTTCAATTCCAGTACGATGTCAGCTCGGCCGCGCAGCCCGGCTGCTCAGTC
CTCGACGAGGCCTTCCAGCGCTATCGTGACCTGCTTTTCGGTTCCGGGTCTTGGCCCCGT
CCTTACCTCACAGGGAAACGGCATACACTGGAGAAGAATGTGTTGGTTGTCTCTGTAGTC
ACACCTGGATGTAACCAGCTTCCTACTTTGGAGTCAGTGGAGAATTATACCCTGACCATA
AATGATGACCAGTGTTTACTCCTCTCTGAGACTGTCTGGGGAGCTCTCCGAGGTCTGGAG
ACTTTTAGCCAGCTTGTTTGGAAATCTGCTGAGGGCACATTCTTTATCAACAAGACTGAG
ATTGAGGACTTTCCCCGCTTTCCTCACCGGGGCTTGCTGTTGGATACATCTCGCCATTAC
CTGCCACTCTCTAGCATCCTGGACACTCTGGATGTCATGGCGTACAATAAATTGAACGTG
TTCCACTGGCATCTGGTAGATGATCCTTCCTTCCCATATGAGAGCTTCACTTTTCCAGAG
CTCATGAGAAAGGGGTCCTACAACCCTGTCACCCACATCTACACAGCACAGGATGTGAAG
GAGGTCATTGAATACGCACGGCTCCGGGGTATCCGTGTGCTTGCAGAGTTTGACACTCCT
GGCCACACTTTGTCCTGGGGACCAGGTATCCCTGGATTACTGACTCCTTGCTACTCTGGG
TCTGAGCCCTCTGGCACCTTTGGACCAGTGAATCCCAGTCTCAATAATACCTATGAGTTC
ATGAGCACATTCTTCTTAGAAGTCAGCTCTGTCTTCCCAGATTTTTATCTTCATCTTGGA
GGAGATGAGGTTGATTTCACCTGCTGGAAGCCCAACCCAGAGATCCAGGACTTTATGAGG
AAGAAAGGCTTCGGTGAGGACTTCAAGCAGCTGGAGTCCTTCTACATCCAGACGCTGCTG
GACATCGTCTCTTCTTATGGCAAGGGCTATGTGGTGTGGCAGGAGGTGTTTGATAATAAA
GTAAAGATTCAGCCAGACACAATCATACAGGTGTGGCGAGAGGATATTCCAGTGAACTAT
ATGAAGGAGCTGGAACTGGTCACCAAGGCCGGCTTCCGGGCCCTTCTCTCTGCCCCCTGG
TACCTGAACCGTATATCCTACGGCCCTGACTGGAAGGATTTCTACGTAGTGGAACCCCTG
GCATTTGAAGGTACCCCTGAGCAGAAGGCTCTGGTGATTGGTGGAGAGGCTTGTATGTGG
GGAGAATATGTGGACAACACAAACCTGGTCCCCAGGCTCTGGCCCAGAGCAGGGGCTGTT
GCCGAAAGGCTGTGGAGCAACAAGTTGACATCTGACCTGACATTTGCCTATGAACGTTTG
TCACACTTCCGCTGTGAGTTGCTGAGGCGAGGTGTCCAGGCCCAACCCCTCAATGTAGGC
TTCTGTGAGCAGGAGTTTGAACAGACCTGA

Protein Properties

Number of Residues

529

Molecular Weight

Not Available

Theoretical pI

Not Available

Pfam Domain Function

Glyco_hydro_20 (PF00728 )
Glyco_hydro_20b (PF02838 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Beta-hexosaminidase subunit alpha
MTSSRLWFSLLLAAAFAGRATALWPWPQNFQTSDQRYVLYPNNFQFQYDVSSAAQPGCSV
LDEAFQRYRDLLFGSGSWPRPYLTGKRHTLEKNVLVVSVVTPGCNQLPTLESVENYTLTI
NDDQCLLLSETVWGALRGLETFSQLVWKSAEGTFFINKTEIEDFPRFPHRGLLLDTSRHY
LPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELMRKGSYNPVTHIYTAQDVK
EVIEYARLRGIRVLAEFDTPGHTLSWGPGIPGLLTPCYSGSEPSGTFGPVNPSLNNTYEF
MSTFFLEVSSVFPDFYLHLGGDEVDFTCWKSNPEIQDFMRKKGFGEDFKQLESFYIQTLL
DIVSSYGKGYVVWQEVFDNKVKIQPDTIIQVWREDIPVNYMKELELVTKAGFRALLSAPW
YLNRISYGPDWKDFYVVEPLAFEGTPEQKALVIGGEACMWGEYVDNTNLVPRLWPRAGAV
AERLWSNKLTSDLTFAYERLSHFRCELLRRGVQAQPLNVGFCEQEFEQT

External Links

GenBank ID Protein

62896563

UniProtKB/Swiss-Prot ID

P06865

UniProtKB/Swiss-Prot Entry Name

HEXA_HUMAN

PDB IDs

GenBank Gene ID

AK222502

GeneCard ID

HEXA