Cannabis Compound Database: Showing Protein Beta-hexosaminidase subunit beta (CDBP00814)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP00814

Secondary Accession Numbers

Not Available

Name

Beta-hexosaminidase subunit beta

Description

Not Available

Synonyms

Beta-N-acetylhexosaminidase subunit beta
Beta-hexosaminidase subunit beta chain A
Beta-hexosaminidase subunit beta chain B
Cervical cancer proto-oncogene 7 protein
HCC-7
Hexosaminidase subunit B
N-acetyl-beta-glucosaminidase subunit beta

Gene Name

HEXB

Protein Type

Enzyme

Biological Properties

General Function

Involved in beta-N-acetylhexosaminidase activity

Specific Function

Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues.

GO Classification

Biological Process
myelination
male courtship behavior
oligosaccharide catabolic process
sensory perception of sound
oogenesis
locomotory behavior
phospholipid biosynthetic process
neuromuscular process controlling balance
N-acetylglucosamine metabolic process
lipid storage
carbohydrate metabolic process
regulation of cell shape
glycosphingolipid metabolic process
phospholipid metabolic process
cell death
penetration of zona pellucida
chondroitin sulfate catabolic process
keratan sulfate catabolic process
lysosome organization
hyaluronan catabolic process
cellular protein metabolic process
cellular calcium ion homeostasis
skeletal system development
positive regulation of transcription from RNA polymerase II promoter
ganglioside catabolic process
astrocyte cell migration
Cellular Component
lysosomal lumen
acrosomal vesicle
membrane
Function
beta-n-acetylhexosaminidase activity
binding
catalytic activity
hydrolase activity
hydrolase activity, acting on glycosyl bonds
hydrolase activity, hydrolyzing o-glycosyl compounds
ion binding
cation binding
hexosaminidase activity
Molecular Function
cation binding
protein homodimerization activity
beta-N-acetylhexosaminidase activity
beta-N-acetylglucosaminidase activity
protein heterodimerization activity
Process
metabolic process
primary metabolic process
carbohydrate metabolic process

Cellular Location

Lysosome

Pathways

Name	SMPDB/Pathwhiz	KEGG
Other glycan degradation	Not Available
Amino sugar and nucleotide sugar metabolism	Not Available
Glycosaminoglycan degradation	Not Available
Glycosphingolipid biosynthesis - globo series	Not Available
Glycosphingolipid biosynthesis - ganglio series	Not Available

Gene Properties

Chromosome Location

Not Available

Locus

Not Available

SNPs

HEXB

Gene Sequence

>1671 bp
ATGGAGCTGTGCGGGCTGGGGCTGCCCCGGCCGCCCATGCTGCTGGCGCTGCTGTTGGCG
ACACTGCTGGCGGCGATGTTGGCGCTGCTGACTCAGGTGGCGCTGGTGGTGCAGGTGGCG
GAGGCGGCTCGGGCCCCGAGCGTCTCGGCCAAGCCGGGGCCGGCGCTGTGGCCCCTGCCG
CTCTCGGTGAAGATGACCCCGAACCTGCTGCATCTCGCCCCGGAGAACTTCTACATCAGC
CACAGCCCCAATTCCACGGCGGGCCCCTCCTGCACCCTGCTGGAGGAAGCGTTTCGACGA
TATCATGGCTATATTTTTGGTTTCTACAAGTGGCATCATGAACCTGCTGAATTCCAGGCT
AAAACCCAGGTTCAGCAACTTCTTGTCTCAATCACCCTTCAGTCAGAGTGTGATGCTTTC
CCCAACATATCTTCAGATGAGTCTTATACTTTACTTGTGAAAGAACCAGTGGCTGTCCTT
AAGGCCAACAGAGTTTGGGGAGCATTACGAGGTTTAGAGACCTTTAGCCAGTTAGTTTAT
CAAGATTCTTATGGAACTTTCACCATCAATGAATCCACCATTATTGATTCTCCAAGGTTT
TCTCACAGAGGAATTTTGATTGATACATCCAGACATTATCTGCCAGTTAAGATTATTCTT
AAAACTCTGGATGCCATGGCTTTTAATAAGTTTAATGTTCTTCACTGGCACATAGTTGAT
GACCAGTCTTTCCCATATCAGAGCATCACTTTTCCTGAGTTAAGCAATAAAGGAAGCTAT
TCTTTGTCTCATGTTTATACACCAAATGATGTCCGTATGGTGATTGAATATGCCAGATTA
CGAGGAATTCGAGTCCTGCCAGAATTTGATACCCCTGGGCATACACTATCTTGGGGAAAA
GGTCAGAAAGACCTCCTGACTCCATGTTACAGTAGACAAAACAAGTTGGACTCTTTTGGA
CCTATAAACCCTACTCTGAATACAACATACAGCTTCCTTACTACATTTTTCAAAGAAATT
AGTGAGGTGTTTCCAGATCAATTCATTCATTTGGGAGGAGATGAAGTGGAATTTAAATGT
TGGGAATCAAATCCAAAAATTCAAGATTTCATGAGGCAAAAAGGCTTTGGCACAGATTTT
AAGAAACTAGAATCTTTCTACATTCAAAAGGTTTTGGATATTATTGCAACCATAAACAAG
GGATCCATTGTCTGGCAGGAGGTTTTTGATGATAAAGCAAAGCTTGCGCCGGGCACAATA
GTTGAAGTATGGAAAGACAGCGCATATCCTGAGGAACTCAGTAGAGTCACAGCATCTGGC
TTCCCTGTAATCCTTTCTGCTCCTTGGTACTTAGATTTGATTAGCTATGGACAAGATTGG
AGGAAATACTATAAAGTGGAACCTCTTGATTTTGGCGGTACTCAGAAACAGAAACAACTT
TTCATTGGTGGAGAAGCTTGTCTATGGGGAGAATATGTGGATGCAACTAACCTCACTCCA
AGATTATGGCCTCGGGCAAGTGCTGTTGGTGAGAGACTCTGGAGTTCCAAAGATGTCAGA
GATATGGATGACGCCTATGACAGACTGACAAGGCACCGCTGCAGGATGGTCGAACGTGGA
ATAGCTGCACAACCTCTTTATGCTGGATATTGTAACCATGAGAACATGTAA

Protein Properties

Number of Residues

556

Molecular Weight

Not Available

Theoretical pI

Not Available

Pfam Domain Function

Glyco_hydro_20 (PF00728 )
Glyco_hydro_20b (PF02838 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Beta-hexosaminidase subunit beta
MELCGLGLPRPPMLLALLLATLLAAMLALLTQVALVVQVAEAARAPSVSAKPGPALWPLP
LSVKMTPNLLHLAPENFYISHSPNSTAGPSCTLLEEAFRRYHGYIFGFYKWHHEPAEFQA
KTQVQQLLVSITLQSECDAFPNISSDESYTLLVKEPVAVLKANRVWGALRGLETFSQLVY
QDSYGTFTINESTIIDSPRFSHRGILIDTSRHYLPVKIILKTLDAMAFNKFNVLHWHIVD
DQSFPYQSITFPELSNKGSYSLSHVYTPNDVRMVIEYARLRGIRVLPEFDTPGHTLSWGK
GQKDLLTPCYSRQNKLDSFGPINPTLNTTYSFLTTFFKEISEVFPDQFIHLGGDEVEFKC
WESNPKIQDFMRQKGFGTDFKKLESFYIQKVLDIIATINKGSIVWQEVFDDKAKLAPGTI
VEVWKDSAYPEELSRVTASGFPVILSAPWYLDLISYGQDWRKYYKVEPLDFGGTQKQKQL
FIGGEACLWGEYVDATNLTPRLWPRASAVGERLWSSKDVRDMDDAYDRLTRHRCRMVERG
IAAQPLYAGYCNHENM

External Links

GenBank ID Protein

21309953

UniProtKB/Swiss-Prot ID

P07686

UniProtKB/Swiss-Prot Entry Name

HEXB_HUMAN

PDB IDs