| Identification |
|---|
| HMDB Protein ID
| CDBP00803 |
| Secondary Accession Numbers
| Not Available |
| Name
| Malate dehydrogenase, mitochondrial |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| MDH2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| Specific Function
| Not Available |
| GO Classification
|
| Biological Process |
| NADH metabolic process |
| malate metabolic process |
| cellular carbohydrate metabolic process |
| tricarboxylic acid cycle |
| gluconeogenesis |
| oxaloacetate metabolic process |
| internal protein amino acid acetylation |
| Cellular Component |
| plasma membrane |
| nucleus |
| mitochondrial inner membrane |
| mitochondrial matrix |
| Function |
| l-malate dehydrogenase activity |
| binding |
| catalytic activity |
| oxidoreductase activity, acting on the ch-oh group of donors, nad or nadp as acceptor |
| oxidoreductase activity, acting on ch-oh group of donors |
| oxidoreductase activity |
| malate dehydrogenase activity |
| Molecular Function |
| L-malate dehydrogenase activity |
| malate dehydrogenase (NADP+) activity |
| nucleotide binding |
| Process |
| cellular carbohydrate metabolic process |
| cellular metabolic process |
| organic acid metabolic process |
| oxoacid metabolic process |
| carboxylic acid metabolic process |
| oxidation reduction |
| dicarboxylic acid metabolic process |
| malate metabolic process |
| metabolic process |
| primary metabolic process |
| carbohydrate metabolic process |
|
| Cellular Location
|
- Mitochondrion matrix
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Citrate cycle (TCA cycle) | Not Available |  | | Glyoxylate and dicarboxylate metabolism | Not Available |  | | Citric Acid Cycle |    | | | Congenital lactic acidosis |    | Not Available | | Fumarase deficiency |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| 7cen-q22 |
| SNPs
| MDH2 |
| Gene Sequence
|
>1017 bp
ATGCTCTCCGCCCTCGCCCGGCCTGTCAGCGCTGCTCTCCGCCGCAGCTTCAGCACCTCA
GCCCAGAACAATGCTAAAGTAGCTGTGCTAGGGGCCTCTGGAGGCATCGGGCAGCCACTT
TCACTTCTCCTGAAGAACAGCCCCTTGGTGAGCCGCCTGACCCTCTATGATATCGCGCAC
ACACCCGGAGTGGCCGCAGATCTGAGCCACATCGAGACCAAAGCCGCTGTGAAAGGCTAC
CTCGGACCTGAACAGCTGCCTGACTGCCTGAAAGGTTGTGATGTGGTAGTTATTCCGGCT
GGAGTCCCCAGAAAGCCAGGCATGACCCGGGACGACCTGTTCAACACCAATGCCACGATT
GTGGCCACCCTGACCGCTGCCTGTGCCCAGCACTGCCCGGAAGCCATGATCTGCGTCATT
GCCAATCCGGTTAATTCCACCATCCCCATCACAGCAGAAGTTTTCAAGAAGCATGGAGTG
TACAACCCCAACAAAATCTTCGGCGTGACGACCCTGGACATCGTCAGAGCCAACACCTTT
GTTGCAGAGCTGAAGGGTTTGGATCCAGCTCGAGTCAACGTCCCTGTCATTGGTGGCCAT
GCTGGGAAGACCATCATCCCCCTGATCTCTCAGTGCACCCCCAAGGTGGACTTTCCCCAG
GACCAGCTGACAGCACTCACTGGGCGGATCCAGGAGGCCGGCACGGAGGTGGTCAAGGCT
AAAGCCGGAGCAGGCTCTGCCACCCTCTCCATGGCGTATGCCGGCGCCCGCTTTGTCTTC
TCCCTTGTGGATGCAATGAATGGAAAGGAAGGTGTTGTGGAATGTTCCTTCGTTAAGTCA
CAGGAAACGGAATGTACCTACTTCTCCACACCGCTGCTGCTTGGGAAAAAGGGCATCGAG
AAGAACCTGGGCATCGGCAAAGTCTCCTCTTTTGAGGAGAAGATGATCTCGGATGCCATC
CCCGAGCTGAAGGCCTCCATCAAGAAGGGGGAAGATTTCGTGAAGACCCTGAAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 338 |
| Molecular Weight
| 35502.935 |
| Theoretical pI
| 8.676 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Malate dehydrogenase, mitochondrial
MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAH
TPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATI
VATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTF
VAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKA
KAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIE
KNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK
|
| External Links |
|---|
| GenBank ID Protein
| 2906146 |
| UniProtKB/Swiss-Prot ID
| P40926 |
| UniProtKB/Swiss-Prot Entry Name
| MDHM_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF047470 |
| GeneCard ID
| MDH2 |
| GenAtlas ID
| MDH2 |
| HGNC ID
| HGNC:6971 |
| References |
|---|
| General References
| Not Available |