| Identification |
|---|
| HMDB Protein ID
| CDBP00793 |
| Secondary Accession Numbers
| Not Available |
| Name
| 3-keto-steroid reductase |
| Description
| Not Available |
| Synonyms
|
- 17-beta-HSD 7
- 17-beta-hydroxysteroid dehydrogenase 7
- Estradiol 17-beta-dehydrogenase 7
|
| Gene Name
| HSD17B7 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in oxidoreductase activity |
| Specific Function
| Responsible for the reduction of the keto group on the C-3 of sterols.
|
| GO Classification
|
| Biological Process |
| cholesterol biosynthetic process |
| estrogen biosynthetic process |
| Cellular Component |
| endoplasmic reticulum membrane |
| plasma membrane |
| integral to membrane |
| Function |
| binding |
| catalytic activity |
| oxidoreductase activity |
| Molecular Function |
| estradiol 17-beta-dehydrogenase activity |
| 3-keto sterol reductase activity |
| nucleotide binding |
| Process |
| metabolic process |
| oxidation reduction |
|
| Cellular Location
|
- Cell membrane
- Single-pass membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | estrogen biosynthesis | Not Available | Not Available | | zymosterol biosynthesis | Not Available | Not Available | | Steroid hormone biosynthesis | Not Available |  | | Steroid Biosynthesis |    |  | | Smith-Lemli-Opitz Syndrome (SLOS) |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1q23 |
| SNPs
| HSD17B7 |
| Gene Sequence
|
>1026 bp
ATGCGAAAGGTGGTTTTGATCACCGGGGCTAGCAGTGGCATTGGCCTGGCCCTCTGCAAG
CGGCTGCTGGCGGAAGATGATGAGCTTCATCTGTGTTTGGCGTGCAGGAACATGAGCAAG
GCAGAAGCTGTCTGTGCTGCTCTGCTGGCCTCTCACCCCACTGCTGAGGTCACCATTGTC
CAGGTGGATGTCAGCAACCTGCAGTCGGTCTTCCGGGCCTCCAAGGAACTTAAGCAAAGG
TTTCAGAGATTAGACTGTATATATCTAAATGCTGGGATCATGCCTAATCCACAACTAAAT
ATCAAAGCACTTTTCTTTGGCCTCTTTTCAAGAAAAGTGATTCATATGTTCTCCACAGCT
GAAGGCCTGCTGACCCAGGGTGATAAGATCACTGCTGATGGACTTCAGGAGGTGTTTGAG
ACCAATGTCTTTGGCCATTTTATCCTGATTCGGGAACTGGAGCCTCTCCTCTGTCACAGT
GACAATCCATCTCAGCTCATCTGGACATCATCTCGCAGTGCAAGGAAATCTAATTTCAGC
CTCGAGGACTTCCAGCACAGCAAAGGCAAGGAACCCTACAGCTCTTCCAAATATGCCACT
GACCTTTTGAGTGTGGCTTTGAACAGGAACTTCAACCAGCAGGGTCTCTATTCCAATGTG
GCCTGTCCAGGTACAGCATTGACCAATTTGACATATGGAATTCTGCCTCCGTTTATATGG
ACGCTGTTGATGCCGGCAATATTGCTACTTCGCTTTTTTGCAAATGCATTCACTTTGACA
CCATATAATGGAACAGAAGCTCTGGTATGGCTTTTCCACCAAAAGCCTGAATCTCTCAAT
CCTCTGATCAAATATCTGAGTGCCACCACTGGCTTTGGAAGAAATTATATTATGACCCAG
AAGATGGACCTAGATGAAGACACTGCTGAAAAATTTTATCAAAAGTTACTGGAACTGGAA
AAGCACATTAGGGTCACTATTCAAAAAACAGATAATCAGGCCAGGCTCAGTGGCTCATGC
CTATAA
|
| Protein Properties |
|---|
| Number of Residues
| 341 |
| Molecular Weight
| 38205.77 |
| Theoretical pI
| 8.103 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>3-keto-steroid reductase
MRKVVLITGASSGIGLALCKRLLAEDDELHLCLACRNMSKAEAVCAALLASHPTAEVTIV
QVDVSNLQSVFRASKELKQRFQRLDCIYLNAGIMPNPQLNIKALFFGLFSRKVIHMFSTA
EGLLTQGDKITADGLQEVFETNVFGHFILIRELEPLLCHSDNPSQLIWTSSRSARKSNFS
LEDFQHSKGKEPYSSSKYATDLLSVALNRNFNQQGLYSNVACPGTALTNLTYGILPPFIW
TLLMPAILLLRFFANAFTLTPYNGTEALVWLFHQKPESLNPLIKYLSATTGFGRNYIMTQ
KMDLDEDTAEKFYQKLLELEKHIRVTIQKTDNQARLSGSCL
|
| External Links |
|---|
| GenBank ID Protein
| 6721095 |
| UniProtKB/Swiss-Prot ID
| P56937 |
| UniProtKB/Swiss-Prot Entry Name
| DHB7_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF098786 |
| GeneCard ID
| HSD17B7 |
| GenAtlas ID
| HSD17B7 |
| HGNC ID
| HGNC:5215 |
| References |
|---|
| General References
| Not Available |