Cannabis Compound Database: Showing Protein Testosterone 17-beta-dehydrogenase 3 (CDBP00791)

Identification Biological properties Gene properties Protein properties External links References XML Show 4 compounds

Identification

HMDB Protein ID

CDBP00791

Secondary Accession Numbers

Not Available

Name

Testosterone 17-beta-dehydrogenase 3

Description

Not Available

Synonyms

17-beta-HSD 3
17-beta-hydroxysteroid dehydrogenase type 3
Testicular 17-beta-hydroxysteroid dehydrogenase

Gene Name

HSD17B3

Protein Type

Enzyme

Biological Properties

General Function

Involved in oxidoreductase activity

Specific Function

Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH.

GO Classification

Biological Process
response to fungicide
response to L-ascorbic acid
cellular response to gonadotropin stimulus
response to ethanol
insecticide metabolic process
organic acid metabolic process
testosterone biosynthetic process
male genitalia development
response to activity
small molecule metabolic process
response to fatty acid
response to arsenic-containing substance
response to lead ion
response to cadmium ion
response to corticosterone stimulus
biphenyl metabolic process
response to herbicide
cellular response to antibiotic
response to vitamin E
hippocampus development
androgen biosynthetic process
Leydig cell differentiation
response to estrogen stimulus
phenol-containing compound metabolic process
Cellular Component
endoplasmic reticulum membrane
Function
binding
catalytic activity
oxidoreductase activity
Molecular Function
testosterone 17-beta-dehydrogenase (NADP+) activity
estradiol 17-beta-dehydrogenase activity
testosterone 17-beta-dehydrogenase (NAD+) activity
nucleotide binding
Process
metabolic process
oxidation reduction

Cellular Location

Not Available

Pathways

Name	SMPDB/Pathwhiz	KEGG
Androgen and Estrogen Metabolism
testosterone biosynthesis	Not Available	Not Available
Steroid hormone biosynthesis	Not Available
17-Beta Hydroxysteroid Dehydrogenase III Deficiency		Not Available
Aromatase deficiency		Not Available

Gene Properties

Chromosome Location

Locus

9q22

SNPs

HSD17B3

Gene Sequence

>933 bp
ATGGGGGACGTCCTGGAACAGTTCTTCATCCTCACAGGGCTGCTGGTGTGCCTGGCCTGC
CTGGCGAAGTGCGTGAGATTCTCCAGATGTGTTTTACTGAACTACTGGAAAGTTTTGCCA
AAGTCTTTCTTGCGGTCAATGGGACAGTGGGCAGTGATCACTGGAGCAGGCGATGGAATT
GGGAAAGCGTACTCGTTCGAGCTAGCAAAACGTGGACTCAATGTTGTCCTTATTAGCCGG
ACGCTGGAAAAACTAGAGGCCATTGCCACAGAGATCGAGCGGACTACAGGGAGGAGTGTG
AAGATTATACAAGCAGATTTTACAAAAGATGACATCTACGAGCATATTAAAGAAAAACTT
GCAGGCTTAGAAATTGGAATTTTAGTCAACAATGTCGGAATGCTTCCAAACCTTCTCCCA
AGCCATTTCCTGAACGCACCGGATGAAATCCAGAGCCTCATCCATTGTAACATCACCTCC
GTAGTCAAGATGACACAGCTAATTCTGAAACATATGGAATCAAGGCAGAAAGGTCTCATC
CTGAACATTTCTTCTGGGATAGCCCTGTTTCCTTGGCCTCTCTACTCCATGTACTCAGCT
TCCAAGGCGTTTGTGTGCGCATTTTCCAAGGCCCTGCAAGAGGAATATAAAGCAAAAGAA
GTCATCATCCAGGTGCTGACCCCATATGCTGTCTCGACTGCAATGACAAAGTATCTAAAT
ACAAATGTGATAACCAAGACTGCTGATGAGTTTGTCAAAGAGTCATTGAATTATGTCACA
ATTGGAGGTGAAACCTGTGGCTGCCTTGCCCATGAAATCTTGGCGGGCTTTCTGAGCCTG
ATCCCGGCCTGGGCCTTCTACAGCGGTGCCTTCCAAAGGCTGCTCCTGACACACTATGTG
GCATACCTGAAGCTCAACACCAAGGTCAGGTAG

Protein Properties

Number of Residues

310

Molecular Weight

34515.345

Theoretical pI

8.66

Pfam Domain Function

adh_short (PF00106 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Testosterone 17-beta-dehydrogenase 3
MGDVLEQFFILTGLLVCLACLAKCVRFSRCVLLNYWKVLPKSFLRSMGQWAVITGAGDGI
GKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQADFTKDDIYEHIKEKL
AGLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVVKMTQLILKHMESRQKGLI
LNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVIIQVLTPYAVSTAMTKYLN
TNVITKTADEFVKESLNYVTIGGETCGCLAHEILAGFLSLIPAWAFYSGAFQRLLLTHYV
AYLKLNTKVR

External Links

GenBank ID Protein

Not Available

UniProtKB/Swiss-Prot ID

P37058

UniProtKB/Swiss-Prot Entry Name

DHB3_HUMAN

PDB IDs

Not Available

GenBank Gene ID

U05659

GeneCard ID