| Identification |
|---|
| HMDB Protein ID
| CDBP00780 |
| Secondary Accession Numbers
| Not Available |
| Name
| Glycerol kinase 2 |
| Description
| Not Available |
| Synonyms
|
- ATP:glycerol 3-phosphotransferase 2
- GK 2
- Glycerokinase 2
- Glycerol kinase, testis specific 2
|
| Gene Name
| GK2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phosphotransferase activity, alcohol group as acceptor |
| Specific Function
| Key enzyme in the regulation of glycerol uptake and metabolism (By similarity).
|
| GO Classification
|
| Biological Process |
| glycerol metabolic process |
| glycerol catabolic process |
| glycerol-3-phosphate metabolic process |
| Cellular Component |
| mitochondrial outer membrane |
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| kinase activity |
| phosphotransferase activity, alcohol group as acceptor |
| glycerol kinase activity |
| Molecular Function |
| ATP binding |
| glycerol kinase activity |
| Process |
| small molecule metabolic process |
| alcohol metabolic process |
| polyol metabolic process |
| alditol metabolic process |
| glycerol metabolic process |
| glycerol-3-phosphate metabolic process |
| metabolic process |
| primary metabolic process |
| carbohydrate metabolic process |
|
| Cellular Location
|
- Cytoplasm
- Peripheral membrane protein
- Cytoplasmic side
- Mitochondrion outer membrane
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | glycerol degradation via glycerol kinase pathway | Not Available | Not Available | | PPAR signaling pathway | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 4 |
| Locus
| 4q13 |
| SNPs
| GK2 |
| Gene Sequence
|
>1662 bp
ATGGCAGCCCCGAAGACAGCAGCTGTGGGGCCGTTGGTGGGAGCGGTGGTCCAGGGCACC
AACTCCACTCGCTTTCTGGTTTTCAATTCAAAAACAGCGGAACTACTTAGTCATCACAAA
GTGGAATTAACACAAGAGTTCCCAAAAGAAGGATGGGTGGAACAAGACCCTAAAGAAATT
CTTCAGTCTGTCTACGAGTGTATAGCGAGAACGTGTGAGAAACTTGACGAACTGAATATT
GATATATCCAACATAAAAGCTGTTGGTGTCAGCAATCAGAGGGAAACCACTGTAATCTGG
GACAAGTTAACAGGAGAGCCTCTCTACAATGCTGTGGTGTGGCTTGATCTAAGAACCCAG
ACTACTGTTGAGGATCTTAGTAAAAAAATTCCAGGAAATAGTAACTTCGTCAAGTCTAAG
ACAGGCCTTCCACTCAGCACTTACTTCAGTGCAGTAAAACTTCGTTGGATGCTTGACAAT
GTGAGAAACGTCCAAAAGGCTGTTGAAGAAGGTAGAGCTCTTTTTGGTACCATTGATTCA
TGGCTTATCTGGAGTTTGACAGGAGGAGTTAATGGAGGCGTGCATTGTACAGATGTAACA
AATGCAAGTAGGACAATGCTTTTTAATATCCATTCTTTGGAATGGGATAAAGAGCTCTGT
GACTTTTTTGAAATTCCAATGGACCTTCTTCCAAATGTCTTCAGTTCTTCTGGGATCTAT
GGCCTAATTAAAACTGGAGCCCTGGAAGGTGTGCCAATATCTGGGTGTTTGGGGGACCAA
TGTGCTGCATTAGTAGGACAAATGTGCTTCCAGGAGGGACAAGCCAAAAACACCTATGGA
ACAGGTTGCTTCTTACTGTGTAATACGGGTCGTAAATGTGTGTTTTCTGAACATGGCCTT
TTGACCACAGTAGCTTACAAACTAGGCAGAGAGAAGCCAGCATATTATGCACTGGAAGGT
TCTGTTGCTATAGCAGGTGCTGTTATTCGTTGGCTAAGAGACAATCTTGGAATTATAGAG
ACCTCAGGAGACATTGAAAGACTTGCTAAAGAAGTAGGAACTTCTTATGGCTGTTACTTT
GTCCCAGCCTTTTCAGGGTTATATACACCTTATTGGGAGCCTAGTGCAAGAGGGATACTC
TGTGGCCTCACTCAGTTTACCAATAAATGTCATATTGCTTTTGCTGCATTAGAAGCTGTT
TGTTTCCAAACCCGAGAGATTTTGGAAGCCATGAACCGTGACTGTGGAATTCCACTTCGT
CATTTGCAGGTAGATGGAGGAATGACCAACAACAAAGTTCTTATGCAGCTACAAGCAGAT
ATTCTTCATATTCCAGTAATAAAACCCTTTATGCCTGAAACAACTGCACTAGGAGCTGCC
ATGGCAGCAGGGGCTGCAGAGGGAGTAAGCGTTTGGAGCCTTGAACCCCAGGCTTTGTCA
GTTCTCAGGATGGAACGATTTGAACCACAGATCCAGGCCACAGAAAGTGAAATTTGTTAT
GCCACATGGAAGAAAGCCGTAATGAAGTCAATGGGTTGGGTTACCAGTCAGTCTCCTGAA
GGTGGTGATCCTTCTATCTTCTCTAGTCTGCCTTTGGGATTTTTTATAGTGAGTAGCATG
GTAATGCTAATTGGAGCAAGATATATCTCGGGTGTGCCATAA
|
| Protein Properties |
|---|
| Number of Residues
| 553 |
| Molecular Weight
| 60593.32 |
| Theoretical pI
| 5.776 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Glycerol kinase 2
MAAPKTAAVGPLVGAVVQGTNSTRFLVFNSKTAELLSHHKVELTQEFPKEGWVEQDPKEI
LQSVYECIARTCEKLDELNIDISNIKAVGVSNQRETTVIWDKLTGEPLYNAVVWLDLRTQ
TTVEDLSKKIPGNSNFVKSKTGLPLSTYFSAVKLRWMLDNVRNVQKAVEEGRALFGTIDS
WLIWSLTGGVNGGVHCTDVTNASRTMLFNIHSLEWDKELCDFFEIPMDLLPNVFSSSEIY
GLIKTGALEGVPISGCLGDQCAALVGQMCFQEGQAKNTYGTGCFLLCNTGRKCVFSEHGL
LTTVAYKLGREKPAYYALEGSVAIAGAVIRWLRDNLGIIETSGDIERLAKEVGTSYGCYF
VPAFSGLYAPYWEPSARGILCGLTQFTNKCHIAFAALEAVCFQTREILEAMNRDCGIPLR
HLQVDGGMTNNKVLMQLQADILHIPVIKPFMPETTALGAAMAAGAAEGVSVWSLEPQALS
VLRMERFEPQIQATESEIRYATWKKAVMKSMGWVTSQSPEGGDPSIFSSLPLGFFIVSSM
VMLIGARYISGVP
|
| External Links |
|---|
| GenBank ID Protein
| 158257914 |
| UniProtKB/Swiss-Prot ID
| Q14410 |
| UniProtKB/Swiss-Prot Entry Name
| GLPK2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK292241 |
| GeneCard ID
| GK2 |
| GenAtlas ID
| GK2 |
| HGNC ID
| HGNC:4291 |
| References |
|---|
| General References
| Not Available |