| Identification |
|---|
| HMDB Protein ID
| CDBP00778 |
| Secondary Accession Numbers
| Not Available |
| Name
| Glutathione peroxidase 2 |
| Description
| Not Available |
| Synonyms
|
- GPRP-2
- GPx-2
- GPx-GI
- GSHPx-2
- GSHPx-GI
- Gastrointestinal glutathione peroxidase
- Glutathione peroxidase-gastrointestinal
- Glutathione peroxidase-related protein 2
|
| Gene Name
| GPX2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in glutathione peroxidase activity |
| Specific Function
| Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors.
|
| GO Classification
|
| Biological Process |
| interaction with symbiont |
| negative regulation of inflammatory response to antigenic stimulus |
| response to symbiotic bacterium |
| response to oxidative stress |
| temperature homeostasis |
| Cellular Component |
| cytoplasm |
| nucleus |
| Function |
| peroxidase activity |
| antioxidant activity |
| glutathione peroxidase activity |
| Molecular Function |
| electron carrier activity |
| glutathione peroxidase activity |
| Process |
| response to stimulus |
| response to stress |
| response to oxidative stress |
| metabolic process |
| oxidation reduction |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 14 |
| Locus
| 14q24.1 |
| SNPs
| GPX2 |
| Gene Sequence
|
>573 bp
ATGGCTTTCATTGCCAAGTCCTTCTATGACCTCAGTGCCATCAGCCTGGATGGGGAGAAG
GTAGATTTCAATACGTTCCGGGGCAGGGCCGTGCTGATTGAGAATGTGCGTTCGCTCTGA
GGCACAACCACCCGGGACTTCACCCAGCTCAACGAGCTGCAATGCCGCTTTCCCAGGCGC
CTGGTGGTCCTTGGCTTCCCTTGCAACCAATTTGGACATCAGGAGAACAGTCAGAATGAG
GAGATCCTGAACAGTCTCAAGTATGTCCGTCCTGGGGGTGGATACCAGCCCACCTTCACC
CTTGTCCAAAAATGTGAGGTGAATGGGCAGAACGAGCATCCTGTCTTCGCCTACCTGAAG
GACAAGCTCCCCTACCCTTATGATGACCCATTTTCCCTCATGACCGATCCCAAGCTCATC
ATTTGGAGCCCTGTGCGCCGCTCAGATGTGGCCTGGAACTTTGAGAAGTTCCTCATAGGG
CCGGAGGGAGAGCCCTTCCGACGCTACAGCCGCACCTTCCCAACCATCAACATTGAGCCT
GACATCAAGCGCCTCCTTAAAGTTGCCATATAG
|
| Protein Properties |
|---|
| Number of Residues
| 190 |
| Molecular Weight
| 21953.835 |
| Theoretical pI
| 7.776 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Glutathione peroxidase 2
MAFIAKSFYDLSAISLDGEKVDFNTFRGRAVLIENVASLUGTTTRDFTQLNELQCRFPRR
LVVLGFPCNQFGHQENCQNEEILNSLKYVRPGGGYQPTFTLVQKCEVNGQNEHPVFAYLK
DKLPYPYDDPFSLMTDPKLIIWSPVRRSDVAWNFEKFLIGPEGEPFRRYSRTFPTINIEP
DIKRLLKVAI
|
| External Links |
|---|
| GenBank ID Protein
| 4902773 |
| UniProtKB/Swiss-Prot ID
| P18283 |
| UniProtKB/Swiss-Prot Entry Name
| GPX2_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| X53463 |
| GeneCard ID
| GPX2 |
| GenAtlas ID
| GPX2 |
| HGNC ID
| HGNC:4554 |
| References |
|---|
| General References
| Not Available |