| Identification |
|---|
| HMDB Protein ID
| CDBP00775 |
| Secondary Accession Numbers
| Not Available |
| Name
| Glutathione peroxidase 3 |
| Description
| Not Available |
| Synonyms
|
- Extracellular glutathione peroxidase
- GPx-3
- GPx-P
- GSHPx-3
- GSHPx-P
- Plasma glutathione peroxidase
|
| Gene Name
| GPX3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in glutathione peroxidase activity |
| Specific Function
| Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.
|
| GO Classification
|
| Biological Process |
| response to corticosterone stimulus |
| response to selenium ion |
| protein homotetramerization |
| hydrogen peroxide catabolic process |
| female pregnancy |
| response to lipid hydroperoxide |
| response to molecule of fungal origin |
| response to drug |
| glutathione metabolic process |
| Cellular Component |
| extracellular space |
| Function |
| peroxidase activity |
| antioxidant activity |
| glutathione peroxidase activity |
| Molecular Function |
| glutathione peroxidase activity |
| glutathione binding |
| selenium binding |
| transcription factor binding |
| Process |
| oxidation reduction |
| response to stimulus |
| response to stress |
| response to oxidative stress |
| metabolic process |
|
| Cellular Location
|
- Secreted
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| 5q23 |
| SNPs
| GPX3 |
| Gene Sequence
|
>681 bp
ATGGCCCGGCTGCTGCAGGCGTCCTGCCTGCTTTCCCTGCTCCTGGCCGGCTTCGTCTCG
CAGAGCCGGGGACAAGAGAAGTCGAAGATGGACTGCCATGGTGGCATAAGTGGCACCATT
TACGAGTACGGAGCCCTCACCATTGATGGGGAGGAGTACATCCCCTTCAAGCAGTATGCT
GGCAAATACGTCCTCTTTGTCAACGTGGCCAGCTACTGAGGCCTGACGGGCCAGTACATT
GAACTGAATGCACTACAGGAAGAGCTTGCACCATTCGGTCTGGTCATTCTGGGCTTTCCC
TGCAACCAATTTGGAAAACAGGAACCAGGAGAGAACTCAGAGATCCTTCCTACCCTCAAG
TATGTCCGACCAGGTGGAGGCTTTGTCCCTAATTTCCAGCTCTTTGAGAAAGGGGATGTC
AATGGAGAGAAAGAGCAGAAATTCTACACTTTCCTAAAGAACTCCTGTCCTCCCACCTCG
GAGCTCCTGGGTACATCTGACCGCCTCTTCTGGGAACCCATGAAGGTTCACGACATCCGC
TGGAACTTTGAGAAGTTCCTGGTGGGGCCAGATGGTATACCCATCATGCGCTGGCACCAC
CGGACCACGGTCAGCAACGTCAAGATGGACATCCTGTCCTACATGAGGCGGCAGGCAGCC
CTGGGGGTCAAGAGGAAGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 226 |
| Molecular Weight
| 25552.185 |
| Theoretical pI
| 8.128 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Glutathione peroxidase 3
MARLLQASCLLSLLLAGFVSQSRGQEKSKMDCHGGISGTIYEYGALTIDGEEYIPFKQYA
GKYVLFVNVASYUGLTGQYIELNALQEELAPFGLVILGFPCNQFGKQEPGENSEILPTLK
YVRPGGGFVPNFQLFEKGDVNGEKEQKFYTFLKNSCPPTSELLGTSDRLFWEPMKVHDIR
WNFEKFLVGPDGIPIMRWHHRTTVSNVKMDILSYMRRQAALGVKRK
|
| External Links |
|---|
| GenBank ID Protein
| 6006001 |
| UniProtKB/Swiss-Prot ID
| P22352 |
| UniProtKB/Swiss-Prot Entry Name
| GPX3_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_002084.3 |
| GeneCard ID
| GPX3 |
| GenAtlas ID
| GPX3 |
| HGNC ID
| HGNC:4555 |
| References |
|---|
| General References
| Not Available |