Cannabis Compound Database: Showing Protein Glutathione peroxidase 1 (CDBP00773)

Identification Biological properties Gene properties Protein properties External links References XML Show 5 compounds

Identification

HMDB Protein ID

CDBP00773

Secondary Accession Numbers

Not Available

Name

Glutathione peroxidase 1

Description

Not Available

Synonyms

Cellular glutathione peroxidase
GPx-1
GSHPx-1

Gene Name

GPX1

Protein Type

Enzyme

Biological Properties

General Function

Involved in glutathione peroxidase activity

Specific Function

Protects the hemoglobin in erythrocytes from oxidative breakdown.

GO Classification

Biological Process
blood vessel endothelial cell migration
triglyceride metabolic process
skeletal muscle fiber development
endothelial cell development
UV protection
purine nucleobase metabolic process
fat cell differentiation
temperature homeostasis
purine nucleotide catabolic process
heart contraction
angiogenesis involved in wound healing
interaction with symbiont
skeletal muscle tissue regeneration
intrinsic apoptotic signaling pathway in response to oxidative stress
negative regulation of apoptotic process
response to gamma radiation
myoblast proliferation
vasodilation
myotube differentiation
glutathione metabolic process
negative regulation of inflammatory response to antigenic stimulus
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
protein oxidation
induction of apoptosis
regulation of gene expression, epigenetic
positive regulation of protein kinase B signaling cascade
regulation of mammary gland epithelial cell proliferation
response to selenium ion
regulation of proteasomal protein catabolic process
sensory perception of sound
response to toxin
response to symbiotic bacterium
cell redox homeostasis
release of cytochrome c from mitochondria
response to hydroperoxide
regulation of neuron apoptotic process
hydrogen peroxide catabolic process
response to xenobiotic stimulus
Cellular Component
cytosol
mitochondrion
Function
peroxidase activity
antioxidant activity
glutathione peroxidase activity
Molecular Function
endopeptidase inhibitor activity
glutathione peroxidase activity
Process
response to stimulus
response to stress
response to oxidative stress
metabolic process
oxidation reduction

Cellular Location

Cytoplasm

Pathways

Name	SMPDB/Pathwhiz	KEGG
Arachidonic Acid Metabolism
Glutathione Metabolism
Amyotrophic lateral sclerosis (ALS)	Not Available
Huntington's disease	Not Available
Glutathione Synthetase Deficiency		Not Available

Gene Properties

Chromosome Location

Locus

3p21.3

SNPs

GPX1

Gene Sequence

>606 bp
ATGTGTGCTGCTCGGCTAGCGGCGGCGGCGGCCCAGTCGGTGTATGCCTTCTCGGCGCGC
CCGTTGGCCGGCGGGGAGCCTGTGAGCCTGGGCTCCCTGCGGGGCAAGGTACTACTTATC
GAGAATGTGGCGTCCCTCTGAGGCACCACGGTCCGGGACTACACCCAGATGAACGAGCTG
CAGCGGCGCCTCGGACCCCGGGGCCTGGTGGTGCTCGGCTTCCCGTGCAACCAGTTTGGG
CATCAGGAGAACGCCAAGAACGAAGAGATTCTGAATTCCCTCAAGTACGTCCGGCCTGGT
GGTGGGTTCGAGCCCAACTTCATGCTCTTCGAGAAGTGCGAGGTGAACGGTGCGGGGGCG
CACCCTCTCTTCGCCTTCCTGCGGGAGGCCCTGCCAGCTCCCAGCGACGACGCCACCGCG
CTTATGACCGACCCCAAGCTCATCACCTGGTCTCCGGTGTGTCGCAACGATGTTGCCTGG
AACTTTGAGAAGTTCCTGGTGGGCCCTGACGGTGTGCCCCTACGCAGGTACAGCCGCCGC
TTCCAGACCATTGACATCGAGCCTGACATCGAAGCCCTGCTGTCTCAAGGGCCCAGCTGT
GCCTAG

Protein Properties

Number of Residues

201

Molecular Weight

22087.94

Theoretical pI

6.548

Pfam Domain Function

GSHPx (PF00255 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Glutathione peroxidase 1
MCAARLAAAAAQSVYAFSARPLAGGEPVSLGSLRGKVLLIENVASLUGTTVRDYTQMNEL
QRRLGPRGLVVLGFPCNQFGHQENAKNEEILNSLKYVRPGGGFEPNFMLFEKCEVNGAGA
HPLFAFLREALPAPSDDATALMTDPKLITWSPVCRNDVAWNFEKFLVGPDGVPLRRYSRR
FQTIDIEPDIEALLSQGPSCA

External Links

GenBank ID Protein

577777

UniProtKB/Swiss-Prot ID

P07203

UniProtKB/Swiss-Prot Entry Name

GPX1_HUMAN

PDB IDs