| Identification |
|---|
| HMDB Protein ID
| CDBP00757 |
| Secondary Accession Numbers
| Not Available |
| Name
| Hydroxyacylglutathione hydrolase, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- Glx II
- Glyoxalase II
|
| Gene Name
| HAGH |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in hydrolase activity |
| Specific Function
| Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
|
| GO Classification
|
| Biological Process |
| glutathione biosynthetic process |
| carbohydrate metabolic process |
| Cellular Component |
| cytoplasm |
| mitochondrial matrix |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| hydrolase activity, acting on ester bonds |
| binding |
| catalytic activity |
| hydrolase activity |
| transition metal ion binding |
| zinc ion binding |
| hydroxyacylglutathione hydrolase activity |
| thiolester hydrolase activity |
| Molecular Function |
| metal ion binding |
| zinc ion binding |
| hydroxyacylglutathione hydrolase activity |
|
| Cellular Location
|
- Isoform 2:Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Pyruvate Metabolism |    |  | | methylglyoxal degradation | Not Available | Not Available | | Leigh Syndrome |    | Not Available | | Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) |    | Not Available | | Pyruvate Dehydrogenase Complex Deficiency |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 16 |
| Locus
| 16p13.3 |
| SNPs
| HAGH |
| Gene Sequence
|
>927 bp
ATGGTGGTGGGCCGAGGGCTGCTCGGCCGCCGCAGCCTCGCCGCGCTGGGAGCCGCCTGC
GCCCGCCGAGGCCTCGGTCCAGCCCTGCTGGGAGTTTTCTGCCACACAGATTTGCGGAAG
AACCTGACCGTGGACGAGGGCACCATGAAGGTAGAGGTGCTGCCTGCCCTGACCGACAAC
TACATGTACCTGGTCATTGATGATGAGACCAAGGAGGCTGCCATTGTGGATCCGGTGCAG
CCCCAGAAGGTCGTGGACGCGGCGAGAAAGCACGGGGTGAAACTGACCACAGTGCTCACC
ACCCACCACCACTGGGACCATGCTGGCGGGAATGAGAAACTGGTCAAGCTGGAGTCGGGA
CTGAAGGTGTACGGGGGTGACGACCGTATCGGGGCCCTGACTCACAAGATCACTCACCTG
TCCACACTGCAGGTGGGGTCTCTGAACGTCAAGTGCCTGGCGACCCCGTGCCACACTTCA
GGACACATTTGTTACTTCGTGAGCAAGCCCGGAGGCTCGGAGCCCCCTGCCGTGTTCACA
GGTGACACCTTGTTTGTGGCTGGCTGCGGGAAGTTCTATGAAGGGACTGCGGATGAGATG
TGTAAAGCTCTGCTGGAGGTCTTGGGCCGGCTCCCCCCGGACACAAGAGTCTACTGTGGC
CACGAGTACACCATCAACAACCTCAAGTTTGCACGCCACGTGGAGCCCGGCAATGCCGCC
ATCCGGGAGAAGCTGGCCTGGGCCAAGGAGAAGTACAGCATCGGGGAGCCCACAGTGCCA
TCCACCCTGGCAGAGGAGTTTACCTACAACCCCTTCATGAGAGTGAGGGAGAAGACGGTG
CAGCAGCACGCAGGTGAGACGGACCCGGTGACCACCATGCGGGCCGTGCGCAGGGAGAAG
GACCAGTTCAAGATGCCCCGGGACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 308 |
| Molecular Weight
| 28859.855 |
| Theoretical pI
| 7.323 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Hydroxyacylglutathione hydrolase, mitochondrial
MVVGRGLLGRRSLAALGAACARRGLGPALLGVFCHTDLRKNLTVDEGTMKVEVLPALTDN
YMYLVIDDETKEAAIVDPVQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESG
LKVYGGDDRIGALTHKITHLSTLQVGSLNVKCLATPCHTSGHICYFVSKPGGSEPPAVFT
GDTLFVAGCGKFYEGTADEMCKALLEVLGRLPPDTRVYCGHEYTINNLKFARHVEPGNAA
IREKLAWAKEKYSIGEPTVPSTLAEEFTYNPFMRVREKTVQQHAGETDPVTTMRAVRREK
DQFKMPRD
|
| External Links |
|---|
| GenBank ID Protein
| 94538322 |
| UniProtKB/Swiss-Prot ID
| Q16775 |
| UniProtKB/Swiss-Prot Entry Name
| GLO2_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_005326.4 |
| GeneCard ID
| HAGH |
| GenAtlas ID
| HAGH |
| HGNC ID
| HGNC:4805 |
| References |
|---|
| General References
| Not Available |