| Identification |
|---|
| HMDB Protein ID
| CDBP00739 |
| Secondary Accession Numbers
| Not Available |
| Name
| Serine hydroxymethyltransferase, cytosolic |
| Description
| Not Available |
| Synonyms
|
- Glycine hydroxymethyltransferase
- SHMT
- Serine methylase
|
| Gene Name
| SHMT1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Interconversion of serine and glycine.
|
| GO Classification
|
| Biological Process |
| glycine biosynthetic process from serine |
| purine nucleobase biosynthetic process |
| carnitine biosynthetic process |
| L-serine catabolic process |
| protein tetramerization |
| folic acid metabolic process |
| tetrahydrofolate interconversion |
| protein homotetramerization |
| Cellular Component |
| cytosol |
| mitochondrion |
| nucleus |
| Function |
| binding |
| catalytic activity |
| transferase activity |
| glycine hydroxymethyltransferase activity |
| cofactor binding |
| pyridoxal phosphate binding |
| transferase activity, transferring one-carbon groups |
| methyltransferase activity |
| Molecular Function |
| glycine hydroxymethyltransferase activity |
| L-allo-threonine aldolase activity |
| amino acid binding |
| pyridoxal phosphate binding |
| protein homodimerization activity |
| Process |
| metabolic process |
| cellular metabolic process |
| serine family amino acid metabolic process |
| glycine metabolic process |
| l-serine metabolic process |
| cellular amino acid and derivative metabolic process |
| cellular amino acid metabolic process |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | tetrahydrofolate interconversion | Not Available | Not Available | | Glycine, serine and threonine metabolism | Not Available |  | | Cyanoamino acid metabolism | Not Available |  | | Glyoxylate and dicarboxylate metabolism | Not Available |  | | One carbon pool by folate | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| 17p11.2 |
| SNPs
| SHMT1 |
| Gene Sequence
|
>1452 bp
ATGACGATGCCAGTCAACGGGGCCCACAAGGATGCTGACCTGTGGTCCTCACATGACAAG
ATGCTGGCACAACCCCTCAAAGACAGTGATGTTGAGGTTTACAACATCATTAAGAAGGAG
AGTAACCGGCAGAGGGTTGGATTGGAGCTGATTGCCTCGGAGAATTTCGCCAGCCGAGCA
GTTTTGGAGGCCCTAGGCTCTTGCTTAAATAACAAATACTCTGAGGGGTACCCGGGCCAG
AGATACTATGGCGGGACTGAGTTTATTGATGAACTGGAGACCCTCTGTCAGAAGCGAGCC
CTGCAGGCCTATAAGCTGGACCCACAGTGCTGGGGGGTCAACGTCCAGCCCTACTCAGGC
TCCCCTGCAAACTTTGCTGTGTACACTGCCCTGGTGGAACCCCATGGGCGCATCATGGGC
CTGGACCTTCCGGATGGGGGCCACCTGACCCATGGGTTCATGACAGACAAGAAGAAAATC
TCTGCCACGTCCATCTTCTTTGAATCTATGCCCTACAAGGTGAACCCAGATACTGGCTAC
ATCAACTATGACCAGCTGGAGGAGAACGCACGCCTCTTCCACCCGAAGCTGATCATCGCA
GGAACCAGCTGCTACTCCCGAAACCTGGAATATGCCCGGCTACGGAAGATTGCAGATGAG
AACGGGGCGTATCTCATGGCGGACATGGCTCACATCAGCGGGCTGGTGGCGGCTGGCGTG
GTGCCCTCCCCATTTGAACACTGCCATGTGGTGACCACCACCACTCACAAGACCCTGCGA
GGCTGCCGAGCTGGCATGATCTTCTACAGGAAAGGAGTGAAAAGTGTGGATCCCAAGACT
GGCAAAGAGATTCTGTACAACCTGGAGTCTCTTATCAATTCTGCTGTGTTCCCTGGCCTG
CAGGGAGGTCCCCACAACCACGCCATTGCTGGGGTTGCTGTGGCACTGAAGCAAGCTATG
ACTCTGGAATTTAAAGTTTATCAACACCAGGTGGTGGCCAACTGCAGGGCTCTGTCTGAG
GCCCTGACGGAGCTGGGCTACAAAATAGTCACAGGTGGTTCTGACAACCATTTGATCCTT
GTGGATCTCCGTTCCAAAGGCACAGATGGTGGAAGGGCTGAGAAGGTGCTAGAAGCCTGT
TCTATTGCCTGCAACAAGAACACCTGTCCAGGTGACAGAAGCGCTCTGCGGCCCAGTGGA
CTGCGGCTGGGGACCCCAGCACTGACGTCCCGTGGACTTTTGGAAAAAGACTTCCAAAAA
GTAGCCCACTTTATTCACAGAGGGATAGAGCTGACCCTGCAGATCCAGAGCGACACTGGT
GTCAGAGCCACCCTGAAAGAGTTCAAGGAGAGACTGGCAGGGGATAAGTACCAGGCGGCC
GTGCAGGCTCTCCGGGAGGAGGTTGAGAGCTTCGCCTCTTTCTTCCCTCTGCCTGGCCTG
CCTGACTTCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 483 |
| Molecular Weight
| 53082.18 |
| Theoretical pI
| 7.705 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Serine hydroxymethyltransferase, cytosolic
MTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRA
VLEALGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSG
SPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGY
INYDQLEENARLFHPKLIIAGTSCYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGV
VPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVKSVDPKTGKEILYNLESLINSAVFPGL
QGGPHNHAIAGVAVALKQAMTLEFKVYQHQVVANCRALSEALTELGYKIVTGGSDNHLIL
VDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQK
VAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQAAVQALREEVESFASLFPLPGL
PDF
|
| External Links |
|---|
| GenBank ID Protein
| 14124914 |
| UniProtKB/Swiss-Prot ID
| P34896 |
| UniProtKB/Swiss-Prot Entry Name
| GLYC_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| BC007979 |
| GeneCard ID
| SHMT1 |
| GenAtlas ID
| SHMT1 |
| HGNC ID
| HGNC:10850 |
| References |
|---|
| General References
| Not Available |