| Identification |
|---|
| HMDB Protein ID
| CDBP00733 |
| Secondary Accession Numbers
| Not Available |
| Name
| Hydroxyacid oxidase 2 |
| Description
| Not Available |
| Synonyms
|
- (S)-2-hydroxy-acid oxidase, peroxisomal
- Cell growth-inhibiting gene 16 protein
- HAOX2
- Long chain alpha-hydroxy acid oxidase
- Long-chain L-2-hydroxy acid oxidase
|
| Gene Name
| HAO2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in FMN binding |
| Specific Function
| Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids.
|
| GO Classification
|
| Biological Process |
| mandelate metabolic process |
| fatty acid oxidation |
| protein homooligomerization |
| Cellular Component |
| mitochondrion |
| peroxisome |
| Function |
| nucleotide binding |
| catalytic activity |
| fmn binding |
| oxidoreductase activity |
| binding |
| Molecular Function |
| FMN binding |
| long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity |
| medium-chain-(S)-2-hydroxy-acid oxidase activity |
| very-long-chain-(S)-2-hydroxy-acid oxidase activity |
| Process |
| metabolic process |
| oxidation reduction |
|
| Cellular Location
|
- Peroxisome
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Glyoxylate and dicarboxylate metabolism | Not Available |  | | Peroxisome | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1p13.3-p13.1 |
| SNPs
| HAO2 |
| Gene Sequence
|
>1056 bp
ATGTCCTTGGTGTGTCTGACAGACTTTCAGGCCCATGCGCGAGAGCAGCTGTCTAAGTCA
ACTCGGGATTTTATTGAAGGTGGAGCAGATGACAGCATCACGCGGGATGACAACATTGCA
GCATTTAAAAGAATTCGCCTCCGTCCGCGGTACCTGAGAGATGTGTCTGAGGTGGACACC
AGAACCACAATCCAAGGGGAGGAGATCAGTGCCCTTATTTGTATCGCACCCACAGGGTAC
CACTGCCTCGTCTGGCCTGATGGGGAAATGAGCACAGCAAGAGCTGCCCAAGCGGCTGGT
ATCTGCTACATCACCAGCACATTTGCCAGCTGTAGCCTTGAAGACATTGTCATTGCAGCT
CCCGAAGGCCTCCGATGGTTCCAACTCTATGTGCATCCAGACCTGCAGCTGAACAAACAG
TTGATCCAGAGGGTAGAATCCCTAGGTTTCAAAGCTTTGGTAATAACTTTGGATACACCT
GTATGTGGCAACAGGCGACATGACATTCGAAACCAGTTGAGGAGGAACTTAACACTAACA
GATCTTCAATCACCTAAAAAGGGAAATGCAATACCTTATTTCCAGATGACTCCTATCAGC
ACTTCTCTCTGCTGGAATGATCTCTCCTGGTTTCAGAGCATAACTCGATTGCCCATCATC
CTGAAAGGGATTTTGACAAAAGAGGATGCAGAGTTAGCTGTGAAGCACAATGTCCAGGGT
ATCATTGTTTCCAACCATGGTGGGAGGCAGCTTGATGAGGTTCTTGCTTCAATTGATGCT
TTGACAGAAGTGGTGGCTGCTGTAAAGGGGAAAATTGAAGTCTACCTGGATGGCGGGGTC
CGAACTGGCAATGATGTGCTGAAGGCTCTGGCCCATGAAGATAAGTGCATTTTTCTTGGG
AGACCAATCCTATGGGGCCTTGCCTGCAAGGGTGAACATGGTGTTAAGGAAGTTTTGAAC
ATTTTAACAAATGAGTTCCACACTTCCATGGCCCTTACAGGCTGCCGGTCGGTCGCTGAG
ATCAATCGAAACTTGGTCCAGTTTTCCAGGCTGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 351 |
| Molecular Weight
| 38838.35 |
| Theoretical pI
| 7.63 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Hydroxyacid oxidase 2
MSLVCLTDFQAHAREQLSKSTRDFIEGGADDSITRDDNIAAFKRIRLRPRYLRDVSEVDT
RTTIQGEEISAPICIAPTGFHCLVWPDGEMSTARAAQAAGICYITSTFASCSLEDIVIAA
PEGLRWFQLYVHPDLQLNKQLIQRVESLGFKALVITLDTPVCGNRRHDIRNQLRRNLTLT
DLQSPKKGNAIPYFQMTPISTSLCWNDLSWFQSITRLPIILKGILTKEDAELAVKHNVQG
IIVSNHGGRQLDEVLASIDALTEVVAAVKGKIEVYLDGGVRTGNDVLKALALGAKCIFLG
RPILWGLACKGEHGVKEVLNILTNEFHTSMALTGCRSVAEINRNLVQFSRL
|
| External Links |
|---|
| GenBank ID Protein
| 6478782 |
| UniProtKB/Swiss-Prot ID
| Q9NYQ3 |
| UniProtKB/Swiss-Prot Entry Name
| HAOX2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF203975 |
| GeneCard ID
| HAO2 |
| GenAtlas ID
| HAO2 |
| HGNC ID
| HGNC:4810 |
| References |
|---|
| General References
| Not Available |