| Identification |
|---|
| HMDB Protein ID
| CDBP00732 |
| Secondary Accession Numbers
| Not Available |
| Name
| Hydroxyacid oxidase 1 |
| Description
| Not Available |
| Synonyms
|
- GOX
- Glycolate oxidase
- HAOX1
|
| Gene Name
| HAO1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in FMN binding |
| Specific Function
| Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate.
|
| GO Classification
|
| Biological Process |
| cellular nitrogen compound metabolic process |
| glyoxylate metabolic process |
| response to oxidative stress |
| fatty acid alpha-oxidation |
| glycolate catabolic process |
| Cellular Component |
| peroxisomal matrix |
| Function |
| binding |
| nucleotide binding |
| catalytic activity |
| fmn binding |
| oxidoreductase activity |
| Molecular Function |
| very-long-chain-(S)-2-hydroxy-acid oxidase activity |
| FMN binding |
| glycolate oxidase activity |
| glyoxylate oxidase activity |
| long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity |
| medium-chain-(S)-2-hydroxy-acid oxidase activity |
| Process |
| metabolic process |
| oxidation reduction |
|
| Cellular Location
|
- Peroxisome
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | glycolate degradation | Not Available | Not Available | | Glyoxylate and dicarboxylate metabolism | Not Available |  | | Peroxisome | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 20 |
| Locus
| 20p12 |
| SNPs
| HAO1 |
| Gene Sequence
|
>1113 bp
ATGCTCCCCCGGCTAATTTGTATCAATGATTATGAACAACATGCTAAATCAGTACTTCCA
AAGTCTATATATGACTATTACAGGTCTGGGGCAAATGATGAAGAAACTTTGGCTGATAAT
ATTGCAGCATTTTCCAGATGGAAGCTGTATCCAAGGATGCTCCGGAATGTTGCTGAAACA
GATCTGTCGACTTCTGTTTTAGGACAGAGGGTCAGCATGCCAATATGTGTGGGGGCTACG
GCCATGCAGCGCATGGCTCATGTGGACGGCGAGCTTGCCACTGTGAGAGCCTGTCAGTCC
CTGGGAACGGGCATGATGTTGAGTTCCTGGGCCACCTCCTCAATTGAAGAAGTGGCGGAA
GCTGGTCCTGAGGCACTTCGTTGGCTGCAACTGTATATCTACAAGGACCGAGAAGTCACC
AAGAAGCTAGTGCGGCAGGCAGAGAAGATGGGCTACAAGGCCATATTTGTGACAGTGGAC
ACACCTTACCTGGGCAACCGTCTGGATGATGTGCGTAACAGATTCAAACTGCCGCCACAA
CTCAGGATGAAAAATTTTGAAACCAGTACTTTATCATTTTCTCCTGAGGAAAATTTTGGA
GACGACAGTGGACTTGCTGCATATGTGGCTAAAGCAATAGACCCATCTATCAGCTGGGAA
GATATCAAATGGCTGAGAAGACTGACATCATTGCCAATTGTTGCAAAGGGCATTTTGAGA
GGTGATGATGCCAGGGAGGCTGTTAAACATGGCTTGAATGGGATCTTGGTGTCGAATCAT
GGGGCTCGACAACTCGATGGGGTGCCAGCCACTATTGATGTTCTGCCAGAAATTGTGGAG
GCTGTGGAAGGGAAGGTGGAAGTCTTCCTGGACGGGGGTGTGCGGAAAGGCACTGATGTT
CTGAAAGCTCTGGCTCTTGGCGCCAAGGCTGTGTTTGTGGGGAGACCAATCGTTTGGGGC
TTAGCTTTCCAGGGGGAGAAAGGTGTTCAAGATGTCCTCGAGATACTAAAGGAAGAATTC
CGGTTGGCCATGGCTCTGAGTGGGTGCCAGAATGTGAAAGTCATCGACAAGACATTGGTG
AGGAAAAATCCTTTGGCCGTTTCCAAGATCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 370 |
| Molecular Weight
| 40923.945 |
| Theoretical pI
| 8.096 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Hydroxyacid oxidase 1
MLPRLICINDYEQHAKSVLPKSIYDYYRSGANDEETLADNIAAFSRWKLYPRMLRNVAET
DLSTSVLGQRVSMPICVGATAMQRMAHVDGELATVRACQSLGTGMMLSSWATSSIEEVAE
AGPEALRWLQLYIYKDREVTKKLVRQAEKMGYKAIFVTVDTPYLGNRLDDVRNRFKLPPQ
LRMKNFETSTLSFSPEENFGDDSGLAAYVAKAIDPSISWEDIKWLRRLTSLPIVAKGILR
GDDAREAVKHGLNGILVSNHGARQLDGVPATIDVLPEIVEAVEGKVEVFLDGGVRKGTDV
LKALALGAKAVFVGRPIVWGLAFQGEKGVQDVLEILKEEFRLAMALSGCQNVKVIDKTLV
RKNPLAVSKI
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9UJM8 |
| UniProtKB/Swiss-Prot Entry Name
| HAOX1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF244134 |
| GeneCard ID
| HAO1 |
| GenAtlas ID
| HAO1 |
| HGNC ID
| HGNC:4809 |
| References |
|---|
| General References
| Not Available |