| Identification |
|---|
| HMDB Protein ID
| CDBP00725 |
| Secondary Accession Numbers
| Not Available |
| Name
| Alcohol dehydrogenase class-3 |
| Description
| Not Available |
| Synonyms
|
- Alcohol dehydrogenase 5
- Alcohol dehydrogenase class chi chain
- Alcohol dehydrogenase class-III
- FALDH
- FDH
- GSH-FDH
- Glutathione-dependent formaldehyde dehydrogenase
- S-(hydroxymethyl)glutathione dehydrogenase
|
| Gene Name
| ADH5 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in zinc ion binding |
| Specific Function
| Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.
|
| GO Classification
|
| Biological Process |
| peptidyl-cysteine S-nitrosylation |
| positive regulation of blood pressure |
| respiratory system process |
| response to lipopolysaccharide |
| response to nitrosative stress |
| response to redox state |
| ethanol oxidation |
| aging |
| ethanol catabolic process |
| retinoid metabolic process |
| formaldehyde catabolic process |
| Cellular Component |
| mitochondrion |
| nucleus |
| Function |
| zinc ion binding |
| oxidoreductase activity, acting on the ch-oh group of donors, nad or nadp as acceptor |
| oxidoreductase activity, acting on ch-oh group of donors |
| oxidoreductase activity |
| s-(hydroxymethyl)glutathione dehydrogenase activity |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| transition metal ion binding |
| Molecular Function |
| electron carrier activity |
| alcohol dehydrogenase (NAD) activity |
| metal ion binding |
| formaldehyde dehydrogenase activity |
| S-(hydroxymethyl)glutathione dehydrogenase activity |
| fatty acid binding |
| zinc ion binding |
| nucleotide binding |
| Process |
| oxidation reduction |
| monohydric alcohol metabolic process |
| ethanol metabolic process |
| ethanol oxidation |
| metabolic process |
| small molecule metabolic process |
| alcohol metabolic process |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Glycolysis / Gluconeogenesis | Not Available |  | | Metabolism of xenobiotics by cytochrome P450 | Not Available |  | | Drug metabolism - cytochrome P450 | Not Available |  | | Chemical carcinogenesis | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 4 |
| Locus
| 4q23 |
| SNPs
| ADH5 |
| Gene Sequence
|
>1125 bp
ATGGCGAACGAGGTTATCAAGTGCAAGGCTGCAGTTGCTTGGGAGGCTGGAAAGCCTCTC
TCCATAGAGGAGATAGAGGTGGCACCCCCAAAGGCTCATGAAGTTCGAATCAAGATCATT
GCCACTGCGGTTTGCCACACCGATGCCTATACCCTGAGTGGAGCTGATCCTGAGGGTTGT
TTTCCAGTGATCTTGGGACATGAAGGTGCTGGAATTGTGGAAAGTGTTGGTGAGGGAGTT
ACTAAGCTGAAGGCGGGTGACACTGTCATCCCACTTTACATCCCACAGTGTGGAGAATGC
AAATTTTGTCTAAATCCTAAAACTAACCTTTGCCAGAAGATAAGAGTCACTCAAGGGAAA
GGATTAATGCCAGATGGTACCAGCAGATTTACTTGCAAAGGAAAGACAATTTTGCATTAC
ATGGGAACCAGCACATTTTCTGAATACACAGTTGTGGCTGATATCTCTGTTGCTAAAATA
GATCCTTTAGCACCTTTGGATAAAGTCTGCCTTCTAGGTTGTGGCATTTCAACCGGTTAT
GGTGCTGCTGTGAACACTGCCAAGTTGGAGCCTGGCTCTGTTTGTGCCGTCTTTGGTCTG
GGAGGAGTCGGATTGGCAGTTATCATGGGCTGTAAAGTGGCTGGTGCTTCCCGGATCATT
GGTGTGGACATCAATAAAGATAAATTTGCAAGGGCCAAAGAGTTTGGAGCCACTGAATGT
ATTAACCCTCAGGATTTTAGTAAACCCATCCAGGAAGTGCTCATTGAGATGACCGATGGA
GGAGTGGACTATTCCTTTGAATGTATTGGTAATGTGAAGGTCATGAGAGCAGCACTTGAG
GCATGTCACAAGGGCTGGGGCGTCAGCGTCGTGGTTGGAGTAGCTGCTTCAGGTGAAGAA
ATTGCCACTCGTCCATTCCAGCTGGTAACAGGTCGCACATGGAAAGGCACTGCCTTTGGA
GGATGGAAGAGTGTAGAAAGTGTCCCAAAGTTGGTGTCTGAATATATGTCCAAAAAGATA
AAAGTTGATGAATTTGTGACTCACAATCTGTCTTTTGATGAAATCAACAAAGCCTTTGAA
CTGATGCATTCTGGAAAGAGCATTCGAACTGTTGTAAAGATTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 374 |
| Molecular Weight
| 39723.945 |
| Theoretical pI
| 7.488 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Alcohol dehydrogenase class-3
MANEVIKCKAAVAWEAGKPLSIEEIEVAPPKAHEVRIKIIATAVCHTDAYTLSGADPEGC
FPVILGHEGAGIVESVGEGVTKLKAGDTVIPLYIPQCGECKFCLNPKTNLCQKIRVTQGK
GLMPDGTSRFTCKGKTILHYMGTSTFSEYTVVADISVAKIDPLAPLDKVCLLGCGISTGY
GAAVNTAKLEPGSVCAVFGLGGVGLAVIMGCKVAGASRIIGVDINKDKFARAKEFGATEC
INPQDFSKPIQEVLIEMTDGGVDYSFECIGNVKVMRAALEACHKGWGVSVVVGVAASGEE
IATRPFQLVTGRTWKGTAFGGWKSVESVPKLVSEYMSKKIKVDEFVTHNLSFDEINKAFE
LMHSGKSIRTVVKI
|
| External Links |
|---|
| GenBank ID Protein
| 178134 |
| UniProtKB/Swiss-Prot ID
| P11766 |
| UniProtKB/Swiss-Prot Entry Name
| ADHX_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| M30471 |
| GeneCard ID
| ADH5 |
| GenAtlas ID
| ADH5 |
| HGNC ID
| HGNC:253 |
| References |
|---|
| General References
| Not Available |