Showing Protein N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 (CDBP00715)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 3 compounds
Identification
HMDB Protein ID CDBP00715
Secondary Accession Numbers Not Available
Name N(G),N(G)-dimethylarginine dimethylaminohydrolase 2
Description Not Available
Synonyms
  1. DDAH-2
  2. DDAHII
  3. Dimethylargininase-2
  4. Dimethylarginine dimethylaminohydrolase 2
  5. Protein G6a
  6. S-phase protein
Gene Name DDAH2
Protein Type Enzyme
Biological Properties
General Function Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
Specific Function Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.
GO Classification
Biological Process
nitric oxide mediated signal transduction
positive regulation of nitric oxide biosynthetic process
arginine catabolic process
nitric oxide biosynthetic process
negative regulation of apoptotic process
citrulline metabolic process
Cellular Component
mitochondrion
Component
cell part
intracellular part
cytoplasm
Function
catalytic activity
hydrolase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Molecular Function
dimethylargininase activity
amino acid binding
Cellular Location
  1. Cytoplasmic
Pathways
Gene Properties
Chromosome Location 6
Locus 6p21.3
SNPs DDAH2
Gene Sequence 
>858 bp
ATGGGGACGCCGGGGGAGGGGCTGGGCCGCTGCTCCCATGCCCTGATCCGGGGAGTCCCA
GAGAGCCTGGCGTCGGGGGAAGGTGCGGGGGCTGGCCTTCCCGCTCTGGATCTGGCCAAA
GCTCAAAGGGAGCACGGGGTGCTGGGAGGTAAACTGAGGCAACGACTGGGGCTACAGCTG
CTAGAACTGCCACCTGAGGAGTCATTGCCGCTGGGACCGCTGCTTGGCGACACGGCCGTG
ATCCAAGGGGACACGGCCCTAATCACGCGGCCCTGGAGCCCCGCTCGTAGGCCAGAGGTC
GATGGAGTCCGCAAAGCCCTGCAAGACCTGGGGCTCCGAATTGTGGAAATAGGAGACGAG
AACGCGACGCTGGATGGCACTGACGTTCTCTTCACCGGCCGGGAGTTTTTCGTAGGCCTC
TCCAAATGGACCAATCACCGAGGAGCTGAGATCGTGGCGGACACGTTCCGGGACTTCGCC
GTCTCCACTGTGCCAGTCTCGGGTCCCTCCCACCTGCGCGGTCTCTGCGGCATGGGGGGA
CCTCGCACTGTTGTGGCAGGCAGCAGCGACGCTGCCCAAAAGGCTGTCCGGGCAATGGCA
GTGCTGACAGATCACCCATATGCCTCCCTGACCCTCCCAGATGACGCAGCTGCTGACTGC
CTCTTTCTTCGTCCTGGGTTGCCTGGTGTGCCCCCTTTCCTCCTGCACCGTGGAGGTGGG
GATCTGCCCAACAGCCAGGAGGCACTGCAGAAGCTCTCTGATGTCACCCTGGTACCTGTG
TCCTGCTCAGAACTGGAGAAGGCTGGCGCCGGGCTCAGCTCCCTCTGCTTGGTGCTCAGC
ACACGCCCCCACAGCTGA
Protein Properties
Number of Residues 285
Molecular Weight 29643.54
Theoretical pI 6.016
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>N(G),N(G)-dimethylarginine dimethylaminohydrolase 2
MGTPGEGLGRCSHALIRGVPESLASGEGAGAGLPALDLAKAQREHGVLGGKLRQRLGLQL
LELPPEESLPLGPLLGDTAVIQGDTALITRPWSPARRPEVDGVRKALQDLGLRIVEIGDE
NATLDGTDVLFTGREFFVGLSKWTNHRGAEIVADTFRDFAVSTVPVSGPSHLRGLCGMGG
PRTVVAGSSDAAQKAVRAMAVLTDHPYASLTLPDDAAADCLFLRPGLPGVPPFLLHRGGG
DLPNSQEALQKLSDVTLVPVSCSELEKAGAGLSSLCLVLSTRPHS
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID O95865
UniProtKB/Swiss-Prot Entry Name DDAH2_HUMAN
PDB IDs Not Available
GenBank Gene ID AF070667
GeneCard ID DDAH2
GenAtlas ID DDAH2
HGNC ID HGNC:2716
References
General References Not Available