| Identification |
|---|
| HMDB Protein ID
| CDBP00714 |
| Secondary Accession Numbers
| Not Available |
| Name
| N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 |
| Description
| Not Available |
| Synonyms
|
- DDAH-1
- DDAHI
- Dimethylargininase-1
- Dimethylarginine dimethylaminohydrolase 1
|
| Gene Name
| DDAH1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines |
| Specific Function
| Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.
|
| GO Classification
|
| Biological Process |
| citrulline metabolic process |
| nitric oxide mediated signal transduction |
| regulation of systemic arterial blood pressure |
| positive regulation of nitric oxide biosynthetic process |
| positive regulation of angiogenesis |
| arginine catabolic process |
| Cellular Component |
| mitochondrion |
| Component |
| cell part |
| intracellular part |
| cytoplasm |
| Function |
| catalytic activity |
| hydrolase activity |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
| Molecular Function |
| amino acid binding |
| metal ion binding |
| dimethylargininase activity |
|
| Cellular Location
|
- Cytoplasmic
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1p22 |
| SNPs
| DDAH1 |
| Gene Sequence
|
>858 bp
ATGGCCGGGCTCGGCCACCCCGCCGCCTTCGGCCGGGCCACCCACGCCGTGGTGCGGGCG
CTACCCGAGTCGCTCGGCCAGCACGCGCTGAGAAGCGCCAAGGGCGAGGAGGTGGACGTC
GCCCGCGCGGAACGGCAGCACCAGCTCTACGTGGGCGTGCTGGGCAGCAAGCTGGGGCTG
CAGGTGGTGGAGCTGCCGGCCGACGAGAGCCTTCCGGACTGCGTCTTCGTGGAGGACGTG
GCCGTGGTGTGCGAGGAGACGGCCCTCATCACCCGACCCGGGGCGCCGAGCCGGAGGAAG
GAGGTTGACATGATGAAAGAAGCATTAGAAAAACTTCAGCTCAATATAGTAGAGATGAAA
GATGAAAATGCAACTTTAGATGGCGGAGATGTTTTATTCACAGGCAGAGAATTTTTTGTG
GGCCTTTCCAAAAGGACAAATCAACGAGGTGCTGAAATCTTGGCTGATACTTTTAAGGAC
TATGCAGTCTCCACAGTGCCAGTGGCAGATGGGTTGCATTTGAAGAGTTTCTGCAGCATG
GCTGGGCCTAACCTGATCGCAATTGGGTCTAGTGAATCTGCACAGAAGGCCCTTAAGATC
ATGCAACAGATGAGTGACCACCGCTACGACAAACTCACTGTGCCTGATGACATAGCAGCA
AACTGTATATATCTAAATATCCCCAACAAAGGGCACGTCTTGCTGCACCGAACCCCGGAA
GAGTATCCAGAAAGTGCAAAGGTTTATGAGAAACTGAAGGACCATATGCTGATCCCCGTG
AGCATGTCTGAACTGGAAAAGGTGGATGGGCTGCTCACCTGCTGCTCAGTTTTAATTAAC
AAGAAAGTAGACTCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 285 |
| Molecular Weight
| 20189.135 |
| Theoretical pI
| 5.84 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
MAGLGHPAAFGRATHAVVRALPESLGQHALRSAKGEEVDVARAERQHQLYVGVLGSKLGL
QVVELPADESLPDCVFVEDVAVVCEETALITRPGAPSRRKEVDMMKEALEKLQLNIVEMK
DENATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFKDYAVSTVPVADGLHLKSFCSM
AGPNLIAIGSSESAQKALKIMQQMSDHRYDKLTVPDDIAANCIYLNIPNKGHVLLHRTPE
EYPESAKVYEKLKDHMLIPVSMSELEKVDGLLTCCSVLINKKVDS
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| O94760 |
| UniProtKB/Swiss-Prot Entry Name
| DDAH1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AB001915 |
| GeneCard ID
| DDAH1 |
| GenAtlas ID
| DDAH1 |
| HGNC ID
| HGNC:2715 |
| References |
|---|
| General References
| Not Available |