Cannabis Compound Database: Showing Protein Deoxyguanosine kinase, mitochondrial (CDBP00713)

Identification Biological properties Gene properties Protein properties External links References XML Show 4 compounds

Identification

HMDB Protein ID

CDBP00713

Secondary Accession Numbers

Not Available

Name

Deoxyguanosine kinase, mitochondrial

Description

Not Available

Synonyms

Gene Name

DGUOK

Protein Type

Enzyme

Biological Properties

General Function

Involved in ATP binding

Specific Function

Required for the phosphorylation of several deoxyribonucleosides and certain nucleoside analogs widely employed as antiviral and chemotherapeutic agents.

GO Classification

Biological Process
purine nucleobase metabolic process
purine-containing compound salvage
dGTP metabolic process
guanosine metabolic process
negative regulation of neuron projection development
protein phosphorylation
purine deoxyribonucleoside metabolic process
Cellular Component
cytosol
mitochondrial matrix
Function
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
phosphotransferase activity, alcohol group as acceptor
Molecular Function
phosphotransferase activity, alcohol group as acceptor
ATP binding
deoxyguanosine kinase activity
Process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
metabolic process
nitrogen compound metabolic process
cellular nitrogen compound metabolic process

Cellular Location

Mitochondrion

Pathways

Name	SMPDB/Pathwhiz	KEGG
Purine Metabolism
Adenosine Deaminase Deficiency		Not Available
Adenylosuccinate Lyase Deficiency		Not Available
Gout or Kelley-Seegmiller Syndrome		Not Available
Lesch-Nyhan Syndrome (LNS)		Not Available

Gene Properties

Chromosome Location

Locus

2p13

SNPs

DGUOK

Gene Sequence

>834 bp
ATGGCCGCGGGCCGCCTCTTTCTAAGTCGGCTTCGAGCACCCTTCAGTTCCATGGCCAAG
AGCCCACTCGAGGGCGTTTCCTCCTCCAGAGGCCTGCACGCGGGGCGCGGGCCCCGAAGG
CTCTCCATCGAAGGCAACATTGCTGTGGGAAAGTCCACGTTTGTGAAGTTACTCACGAAA
ACTTACCCAGAATGGCACGTAGCTACAGAACCTGTAGCAACATGGCAGAATATCCAGGCT
GCTGGCACCCAAAAAGCCTGCACTGCCCAAAGTCTTGGAAACTTGCTGGATATGATGTAC
CGGGAGCCAGCACGATGGTCCTACACATTCCAGACATTTTCCTTTTTGAGCCGCCTGAAA
GTACAGCTGGAGCCCTTCCCTGAGAAACTCTTACAGGCCAGGAAGCCAGTACAGATCTTT
GAGAGGTCTGTGTACAGTGACAGGTATATCTTTGCAAAGAATCTTTTTGAAAATGGTTCC
CTCAGTGACATCGAGTGGCATATCTATCAGGACTGGCATTCTTTTCTCCTGTGGGAGTTT
GCCAGCCGGATCACATTACATGGCTTCATCTACCTCCAGGCTTCTCCCCAGGTTTGTTTG
AAGAGACTGTACCAGAGGGCCAGGGAGGAGGAGAAAGGAATTGAGCTGGCCTATCTAGAG
CAGCTGCATGGCCAACACGAAGCCTGGCTTATTCACAAGACAACGAAGCTCCACTTTGAG
GCTCTGATGAACATTCCAGTGCTGGTGTTGGATGTCAATGATGATTTTTCTGAGGAAGTA
ACCAAACAAGAAGACCTCATGAGAGAGGTAAACACCTTTGTAAAGAATCTGTAA

Protein Properties

Number of Residues

277

Molecular Weight

32055.53

Theoretical pI

8.661

Pfam Domain Function

dNK (PF01712 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Deoxyguanosine kinase, mitochondrial
MAAGRLFLSRLRAPFSSMAKSPLEGVSSSRGLHAGRGPRRLSIEGNIAVGKSTFVKLLTK
TYPEWHVATEPVATWQNIQAAGTQKACTAQSLGNLLDMMYREPARWSYTFQTFSFLSRLK
VQLEPFPEKLLQARKPVQIFERSVYSDRYIFAKNLFENGSLSDIEWHIYQDWHSFLLWEF
ASRITLHGFIYLQASPQVCLKRLYQRAREEEKGIELAYLEQLHGQHEAWLIHKTTKLHFE
ALMNIPVLVLDVNDDFSEEVTKQEDLMREVNTFVKNL

External Links

GenBank ID Protein

16041753

UniProtKB/Swiss-Prot ID

Q16854

UniProtKB/Swiss-Prot Entry Name

DGUOK_HUMAN

PDB IDs