Showing Protein DNA-directed RNA polymerase I subunit RPA49 (CDBP00705)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 4 compounds
Identification
HMDB Protein ID CDBP00705
Secondary Accession Numbers Not Available
Name DNA-directed RNA polymerase I subunit RPA49
Description Not Available
Synonyms
  1. DNA-directed RNA polymerase I subunit E
  2. RNA polymerase I subunit A49
  3. RNA polymerase I-associated factor 1
  4. RNA polymerase I-associated factor 53
Gene Name POLR1E
Protein Type Enzyme
Biological Properties
General Function Involved in DNA binding
Specific Function DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Appears to be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBTF/UBF (By similarity).
GO Classification
Biological Process
rRNA transcription
Cellular Component
cytoplasm
nucleolus
cell junction
Component
organelle
membrane-bounded organelle
intracellular membrane-bounded organelle
nucleus
Function
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
nucleotidyltransferase activity
nucleic acid binding
dna binding
rna polymerase activity
dna-directed rna polymerase activity
Molecular Function
DNA-directed RNA polymerase activity
DNA binding
Process
macromolecule biosynthetic process
cellular macromolecule biosynthetic process
metabolic process
biosynthetic process
transcription
Cellular Location
  1. Nucleus
  2. nucleolus
Pathways
Gene Properties
Chromosome Location 9
Locus 9p13.2
SNPs POLR1E
Gene Sequence 
>1446 bp
ATGTACCAGGCCTCTGCTGTCAGCCTCCTTCCGCGAGACATTCCCTCCTGTCACAGCCCC
TCCCCAGGGTTCTCCCACCTCCCTACCTCCTCTTCTCAGCTGGCCCCGGATCTCCTCCAG
TTCCCTTTGGGTCAGGACCCGAGCTTCCTTGCCATCCCCATTCTGGCACTCCCTCCCAGT
GACAGTCTAGTCCCACCGTACATTGTGTGGTACATTGTGTGGCCTTCTGCTCTCATCTCA
TTCTTGGGCTGCACTCTTACAGTCCAGTTCTCCAACGGGAAGCTACAGAGTCCAGGCAAC
ATGCGCTTTACCTTGTATGAGAACAAAGATTCCACCAACCCCAGGAAGAGGAATCAACGG
ATCCTGGCAGCTGAAACAGATAGGCTCTCCTATGTGGGAAACAATTTTGGGACTGGAGCC
CTCAAATGCAACACTTTGTGCAGGCACTTTGTGGGAATTTTGAACAAGACCTCTGGCCAA
ATGGAAGTATATGATGCTGAATTGTTCAACATGCAGCCACTATTTTCAGATGTATCAGTC
GAGAGTGAACTGGCGCTAGAGAGTCAGACCAAAACTTACAGAGAAAAGATGGATTCTTGT
ATTGAAGCCTTTGGTACCACCAAACAGAAGCGAGCTCTGAACACCAGGAGAATGAACAGA
GTTGGCAATGAATCTTTGAATCGTGCAGTGGCTAAAGCTGCAGAGACTATCATTGATACG
AAGGGTGTGACTGCTCTGGTCAGCGATGCTATCCACAATGACTTGCAAGATGACTCCCTC
TACCTTCCTCCCTGCTATGATGATGCAGCCAAGCCTGAAGACGTGTATAAATTTGAAGAT
CTTCTTTCCCCTGCGGAGTATGAAGCTCTTCAGAGCCCATCTGAAGCTTTCAGGAACGTC
ACGTCAGAAGAAATACTGAAGATGATTGAGGAGAACAGCCATTGCACCTTTGTCATAGAA
GCGTTGAAGTCTTTGCCATCAGATGTGGAGAGCCGAGACCGCCAGGCCCGATGCATATGG
TTTCTGGATACCCTCATCAAATTTCGAGCTCATAGGGTAGTTAAGCGGAAAAGTGCTCTG
GGACCTGGAGTTCCCCACATCATCAACACCAAACTGCTGAAGCACTTTACTTGCTTGACC
TACAACAATGGCAGATTACGGAACTTAATTTCGGATTCTATGAAGGCGAAGATTACCGCA
TATGTGATCATACTTGCCTTGCACATACATGACTTCCAAATTGACCTGACAGTGTTACAG
AGGGACTTGAAGCTCAGTGAGAAAAGGATGATGGAGATAGCCAAAGCCATGAGGCTGAAG
ATCTCCAAAAGAAGGGTGTCTGTGGCCGCCGGCAGTGAAGAAGATCACAAACTGGGCACC
CTGTCCCTCCCGCTGCCTCCAGCCCAGACCTCAGACCGCCTGGCAAAGCGGAGGAAGATT
ACCTAG
Protein Properties
Number of Residues 481
Molecular Weight 47259.7
Theoretical pI 8.936
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>DNA-directed RNA polymerase I subunit RPA49
MYQASAVSLLPRDIPSCHSPSPGFSHLPTSSSQLAPDLLQFPLGQDPSFLAIPILTLPPS
DSLVPPYIVWYIVWPSALISFLGCTLTVQFSNGKLQSPGNMRFTLYENKDSTNPRKRNQR
ILAAETDRLSYVGNNFGTGALKCNTLCRHFVGILNKTSGQMEVYDAELFNMQPLFSDVSV
ESELALESQTKTYREKMDSCIEAFGTTKQKRALNTRRMNRVGNESLNRAVAKAAETIIDT
KGVTALVSDAIHNDLQDDSLYLPPCYDDAAKPEDVYKFEDLLSPAEYEALQSPSEAFRNV
TSEEILKMIEENSHCTFVIEALKSLPSDVESRDRQARCIWFLDTLIKFRAHRVVKRKSAL
GPGVPHIINTKLLKHFTCLTYNNGRLRNLISDSMKAKITAYVIILALHIHDFQIDLTVLQ
RDLKLSEKRMMEIAKAMRLKISKRRVSVAAGSEEDHKLGTLSLPLPPAQTSDRLAKRRKI
T
GenBank ID Protein 21749630
UniProtKB/Swiss-Prot ID Q9GZS1
UniProtKB/Swiss-Prot Entry Name RPA49_HUMAN
PDB IDs Not Available
GenBank Gene ID AK091294
GeneCard ID POLR1E
GenAtlas ID POLR1E
HGNC ID HGNC:17631
References
General References Not Available