| Identification |
|---|
| HMDB Protein ID
| CDBP00702 |
| Secondary Accession Numbers
| Not Available |
| Name
| Phosphatidate cytidylyltransferase 2 |
| Description
| Not Available |
| Synonyms
|
- CDP-DAG synthase 2
- CDP-DG synthase 2
- CDP-diacylglycerol synthase 2
- CDP-diglyceride pyrophosphorylase 2
- CDP-diglyceride synthase 2
- CDS 2
- CTP:phosphatidate cytidylyltransferase 2
|
| Gene Name
| CDS2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in transferase activity, transferring phosphorus-containing groups |
| Specific Function
| Provides CDP-diacylglycerol an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin.
|
| GO Classification
|
| Biological Process |
| small molecule metabolic process |
| CDP-diacylglycerol biosynthetic process |
| phosphatidylglycerol biosynthetic process |
| Cellular Component |
| endoplasmic reticulum |
| integral to membrane |
| mitochondrial inner membrane |
| Component |
| membrane |
| cell part |
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| Molecular Function |
| phosphatidate cytidylyltransferase activity |
|
| Cellular Location
|
- Mitochondrion inner membrane
- Multi-pass membrane protein
- Matrix side (Potential)
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | CDP-diacylglycerol biosynthesis | Not Available | Not Available | | Glycerophospholipid metabolism | Not Available |  | | Phosphatidylinositol signaling system | Not Available |  | | Cardiolipin Biosynthesis CL(i-13:0/i-16:0/i-13:0/i-17:0) |    | Not Available | | Cardiolipin Biosynthesis CL(i-14:0/i-15:0/i-20:0/i-18:0) |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 20 |
| Locus
| 20p13 |
| SNPs
| CDS2 |
| Gene Sequence
|
>1338 bp
ATGACAGAGCTGAGGCAGAGGGTGGCCCATGAGCCGGTTGCGCCACCCGAGGACAAGGAG
TCAGAGTCAGAAGCAAAGGTAGATGGAGAGACTGCATCGGACAGTGAGAGCCGGGCAGAA
TCCGCACCCCTGCCAGTCTCTGCAGATGATACCCCGGAGGTCCTCAATAGGGCCCTTTCC
AACTTGTCTTCAAGATGGAAGAACTGGTGGGTGAGAGGCATCCTGACTTTGGCCATGATT
GCATTTTTCTTCATCATCATTTACCTGGGACCAATGGTTTTGATGATAATCGTGATGTGC
GTTCAGATTAAGTGTTTCCATGAGATAATCACTATTGGCTACAACGTCTACCACTCATAT
GATCTGCCCTGGTTCAGGACGCTCAGCTGGTACTTTCTCCTGTGTGTAAACTATTTCTTC
TATGGTGAGACAGTGACGGATTACTTCTTCACCCTGGTCCAGAGAGAAGAGCCTTTGCGG
ATTCTCAGTAAATACCACCGGTTCATTTCCTTTACTCTCTATCTAATAGGATTCTGCATG
TTTGTACTGAGTCTGGTCAAGAAGCATTATCGACTGCAGTTCTACATGTTTGGCTGGACC
CATGTGACATTGCTGATTGTTGTAACACAGTCACATCTTGTTATCCACAACCTATTTGAA
GGAATGATCTGGTTCATTGTCCCCATATCTTGTGTGATCTGTAATGACATCATGGCCTAT
ATGTTTGGCTTTTTCTTTGGTCGGACCCCACTCATCAAGCTGTCCCCGAAGAAGACCTGG
GAAGGCTTCATTGGGGGCTTCTTTGCTACTGTGGTGTTTGGCCTTCTGCTGTCCTATGTG
ATGTCCGGGTACAGATGCTTTGTCTGCCCTGTGGAGTACAACAATGACACCAACAGCTTC
ACTGTGGACTGTGAGCCCTCGGACCTGTTTCGCCTGCAGGAGTACAACATTCCTGGGGTG
ATCCAGTCAGTCATTGGCTGGAAAACGGTCCGGATGTACCCCTTCCAGATTCACAGCATC
GCTCTCTCCACCTTTGCCTCGCTCATTGGCCCCTTTGGAGGATTCTTCGCAAGTGGATTC
AAACGAGCCTTTAAAATCAAAGACTTTGCCAATACCATTCCTGGCCATGGAGGCATCATG
GATCGCTTTGACTGCCAGTATCTGATGGCCACCTTTGTCAATGTATACATCGCCAGTTTT
ATCAGAGGCCCTAACCCAAGCAAACTGATTCAGCAGTTCCTGACTTTACGGCCAGATCAG
CAGCTCCACATCTTCAACACGCTGCGGTCTCATCTGATCGACAAAGGGATGCTGACATCC
ACCACAGAGGACGAGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 445 |
| Molecular Weight
| 51417.5 |
| Theoretical pI
| 7.09 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Phosphatidate cytidylyltransferase 2
MTELRQRVAHEPVAPPEDKESESEAKVDGETASDSESRAESAPLPVSADDTPEVLNRALS
NLSSRWKNWWVRGILTLAMIAFFFIIIYLGPMVLMIIVMCVQIKCFHEIITIGYNVYHSY
DLPWFRTLSWYFLLCVNYFFYGETVTDYFFTLVQREEPLRILSKYHRFISFTLYLIGFCM
FVLSLVKKHYRLQFYMFGWTHVTLLIVVTQSHLVIHNLFEGMIWFIVPISCVICNDIMAY
MFGFFFGRTPLIKLSPKKTWEGFIGGFFATVVFGLLLSYVMSGYRCFVCPVEYNNDTNSF
TVDCEPSDLFRLQEYNIPGVIQSVIGWKTVRMYPFQIHSIALSTFASLIGPFGGFFASGF
KRAFKIKDFANTIPGHGGIMDRFDCQYLMATFVNVYIASFIRGPNPSKLIQQFLTLRPDQ
QLHIFNTLRSHLIDKGMLTSTTEDE
|
| External Links |
|---|
| GenBank ID Protein
| 4186023 |
| UniProtKB/Swiss-Prot ID
| O95674 |
| UniProtKB/Swiss-Prot Entry Name
| CDS2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Y16521 |
| GeneCard ID
| CDS2 |
| GenAtlas ID
| CDS2 |
| HGNC ID
| HGNC:1801 |
| References |
|---|
| General References
| Not Available |