Cannabis Compound Database: Showing Protein Cholesterol side-chain cleavage enzyme, mitochondrial (CDBP00687)

Identification Biological properties Gene properties Protein properties External links References XML Show 7 compounds

Identification

HMDB Protein ID

CDBP00687

Secondary Accession Numbers

Not Available

Name

Cholesterol side-chain cleavage enzyme, mitochondrial

Description

Not Available

Synonyms

CYPXIA1
Cholesterol desmolase
Cytochrome P450 11A1
Cytochrome P450(scc)

Gene Name

CYP11A1

Protein Type

Metal Binding

Biological Properties

General Function

Involved in monooxygenase activity

Specific Function

Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.

GO Classification

Biological Process
cellular response to follicle-stimulating hormone stimulus
maternal process involved in female pregnancy
response to salt stress
cellular response to peptide hormone stimulus
response to hydrogen peroxide
Schwann cell differentiation
dibenzo-p-dioxin metabolic process
response to vitamin E
vitamin D metabolic process
fractalkine metabolic process
estrogen biosynthetic process
cellular response to cAMP
granulosa cell differentiation
cellular response to tumor necrosis factor
cholesterol metabolic process
hippocampus development
response to drug
Leydig cell differentiation
cellular response to lipopolysaccharide
mating behavior
cellular response to interleukin-1
phenol-containing compound metabolic process
xenobiotic metabolic process
phthalate metabolic process
cellular response to cadmium ion
progesterone biosynthetic process
cerebellum development
response to acid
response to fungicide
biphenyl metabolic process
response to alkaloid
response to gamma radiation
C21-steroid hormone biosynthetic process
testosterone biosynthetic process
response to genistein
cellular response to antibiotic
response to corticosterone stimulus
response to insecticide
cellular response to fibroblast growth factor stimulus
cellular response to transforming growth factor beta stimulus
response to L-ascorbic acid
Cellular Component
mitochondrial matrix
mitochondrial crista
perikaryon
Function
heme binding
oxidoreductase activity
ion binding
cation binding
metal ion binding
binding
catalytic activity
transition metal ion binding
electron carrier activity
iron ion binding
monooxygenase activity
Molecular Function
electron carrier activity
cholesterol binding
cholesterol monooxygenase (side-chain-cleaving) activity
iron ion binding
heme binding
Process
metabolic process
oxidation reduction

Cellular Location

Mitochondrion membrane

Pathways

Name	SMPDB/Pathwhiz	KEGG
Steroidogenesis
C21-steroid hormone metabolism	Not Available	Not Available
Steroid hormone biosynthesis	Not Available
Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia due to 21-hydroxylase Deficiency		Not Available
Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH		Not Available

Gene Properties

Chromosome Location

Locus

15q23-q24

SNPs

CYP11A1

Gene Sequence

>1566 bp
ATGCTGGCCAAGGGTCTTCCCCCACGCTCAGTCCTGGTCAAAGGCTGCCAGACCTTTCTG
AGTGCCCCCAGGGAGGGGCTGGGGCGTCTCAGGGTGCCCACTGGCGAGGGAGCTGGCATC
TCCACCCGCAGTCCTCGCCCCTTCAATGAGATCCCCTCTCCTGGTGACAATGGCTGGCTA
AACCTGTACCATTTCTGGAGGGAGACGGGCACACACAAAGTCCACCTTCACCATGTCCAG
AATTTCCAGAAGTATGGCCCGATTTACAGGGAGAAGCTCGGCAACGTGGAGTCGGTTTAT
GTCATCGACCCTGAAGATGTGGCCCTTCTCTTTAAGTCCGAGGGCCCCAACCCAGAACGA
TTCCTCATCCCGCCCTGGGTCGCCTATCACCAGTATTACCAGAGACCCATAGGAGTCCTG
TTGAAGAAGTCGGCAGCCTGGAAGAAAGACCGGGTGGCCCTGAACCAGGAGGTGATGGCT
CCAGAGGCCACCAAGAACTTTTTGCCCCTGTTGGATGCAGTGTCTCGGGACTTCGTCAGT
GTCCTGCACAGGCGCATCAAGAAGGCGGGCTCCGGAAATTACTCGGGGGACATCAGTGAT
GACCTGTTCCGCTTTGCCTTTGAGTCCATCACTAACGTCATTTTTGGGGAGCGCCAGGGG
ATGCTGGAGGAAGTAGTGAACCCCGAGGCCCAGCGATTCATTGATGCCATCTACCAGATG
TTCCACACCAGCGTCCCCATGCTCAACCTTCCCCCAGACCTGTTCCGTCTGTTCAGGACC
AAGACCTGGAAGGACCATGTGGCTGCATGGGACGTGATTTTCAGTAAAGCTGACATATAC
ACCCAGAACTTCTACTGGGAATTGAGACAGAAAGGAAGTGTTCACCACGATTACCGTGGC
ATCCTCTACAGACTCCTGGGAGACAGCAAGATGTCCTTCGAGGACATCAAGGCCAACGTC
ACAGAGATGCTGGCAGGAGGGGTGGACACGACGTCCATGACCCTGCAGTGGCACTTGTAT
GAGATGGCACGCAACCTGAAGGTGCAGGATATGCTGCGGGCAGAGGTCTTGGCTGCGCGG
CACCAGGCCCAGGGAGACATGGCCACGATGCTACAGCTGGTCCCCCTCCTCAAAGCCAGC
ATCAAGGAGACACTAAGACTTCACCCCATCTCCGTGACCCTGCAGAGATATCTTGTAAAT
GACTTGGTTCTTCGAGATTACATGATTCCTGCCAAGACACTGGTGCAAGTGGCCATCTAT
GCTCTGGGCCGAGAGCCCACCTTCTTCTTCGACCCGGAAAATTTTGACCCAACCCGATGG
CTGAGCAAAGACAAGAACATCACCTACTTCCGGAACTTGGGCTTTGGCTGGGGTGTGCGG
CAGTGTCTGGGACGGCGGATCGCTGAGCTAGAGATGACCATCTTCCTCATCAATATGCTG
GAGAACTTCAGAGTTGAAATCCAACACCTCAGCGATGTGGGCACCACATTCAACCTCATT
CTGATGCCTGAAAAGCCCATCTCCTTCACCTTCTGGCCCTTTAACCAGGAAGCAACCCAG
CAGTGA

Protein Properties

Number of Residues

521

Molecular Weight

60101.87

Theoretical pI

8.834

Pfam Domain Function

p450 (PF00067 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Cholesterol side-chain cleavage enzyme, mitochondrial
MLAKGLPPRSVLVKGCQTFLSAPREGLGRLRVPTGEGAGISTRSPRPFNEIPSPGDNGWL
NLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPER
FLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVS
VLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQM
FHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRG
ILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAAR
HQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIY
ALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINML
ENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQEATQQ

External Links

GenBank ID Protein

158258032

UniProtKB/Swiss-Prot ID

P05108

UniProtKB/Swiss-Prot Entry Name

CP11A_HUMAN

PDB IDs